RESUMEN

Several polyamine derivatives were synthesized in order to produce novel antagonists of muscular nicotinic acetylcholine receptors. Their affinities were compared with those of philanthotoxin PhTX-343.

Asunto(s)

Antagonistas Nicotínicos/síntesis química , Poliaminas/síntesis química , Animales , Humanos , Antagonistas Nicotínicos/farmacología , Poliaminas/farmacología , Relación Estructura-Actividad