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BACKGROUND: This investigation delineated the survival rates and transitional probability trends of patients with endometrial cancer. This information is pivotal for optimizing patient management and counseling strategies. METHODS: We conducted a retrospective cohort analysis of patients diagnosed with stage I or II endometrial cancer between November 2006 and October 2012 and those diagnosed with stage III or IV endometrial cancer between January 2012 and May 2017 at Siriraj Hospital, Bangkok, Thailand. Our examination included baseline demographics, clinical characteristics, and adjuvant therapy data. Survival rates and transitional probabilities were assessed using the Kaplan-Meier method for survival curve construction and Markov models, respectively. RESULTS: After exclusions, 229 individuals with early-stage endometrial cancer and 119 with advanced-stage histologically verified endometrial cancer were included in the final cohort. Throughout a median follow-up duration of 12.8 years, the 5-year overall survival rates were 89.05% for the early-stage cohort and 50.42% for the advanced-stage cohort. The transitional probability analysis revealed an elevated likelihood of achieving a curative state in early-stage patients, contrasting with a greater propensity for disease progression or distant metastasis in advanced-stage patients. CONCLUSIONS: The findings from this study offer critical insights into the overall survival rates and transitional probabilities of endometrial cancer patients. These insights underscore the importance of strategies focused on preventing recurrence and enhancing treatment. Moreover, the results serve as a cornerstone for clinicians in devising individualized treatment plans and facilitating cost-effective analyses in the context of endometrial cancer care.
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Neoplasias Endometriales , Humanos , Femenino , Neoplasias Endometriales/mortalidad , Neoplasias Endometriales/patología , Neoplasias Endometriales/terapia , Estudios Retrospectivos , Tailandia/epidemiología , Tasa de Supervivencia , Persona de Mediana Edad , Estudios de Seguimiento , Anciano , Pronóstico , Estudios Longitudinales , Estadificación de Neoplasias , AdultoRESUMEN
INTRODUCTION: Preoperative assessment of ovarian tumors to distinguish between benign and malignant is important. At this time, many diagnostic models were available and the popularity of the risk of malignancy index (RMI) in Thailand is still high. The IOTA Assessment of Different NEoplasias in adneXa (ADNEX) model and the Ovarian-Adnexal Reporting and Data System (O-RADS) model were both new models with good performance. OBJECTIVES: The purpose of this study was to compare O-RADS, RMI, and ADNEX models. DESIGN: This diagnostic study was performed using data from the prospective study. METHODS: Data from 357 patients from a previous study were included and calculated using the RMI-2 formula then applied to the O-RADS system and the IOTA ADNEX model. The diagnostic significance of the results was evaluated by receiver operating characteristic (ROC) analysis and pairwise comparison between models was made. RESULTS: The area under the receiver operating characteristic curve (AUC) to distinguish an adnexal mass as a benign or malignant tumor was 0.975 (95% CI, 0.953-0.988) for the IOTA ADNEX model; 0.974 (95% CI, 0.960-0.988) for O-RADS; 0.909 for RMI-2 (95% CI, 0.865-0.952). There were no differences in pairwise AUC comparisons between the IOTA ADNEX and O-RADS models, and both were better than those of RMI-2. CONCLUSIONS: The IOTA ADEX and O-RADS models are excellent tools for distinguishing the adnexal mass in the preoperative assessment and were better than RMI-2. The use of one of these models is recommended.
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Enfermedades de los Anexos , Neoplasias Ováricas , Femenino , Humanos , Enfermedades de los Anexos/patología , Neoplasias Ováricas/patología , Estudios Prospectivos , Factores de Riesgo , Sensibilidad y Especificidad , UltrasonografíaRESUMEN
INTRODUCTION: Distinguishing benign adnexal masses from malignant tumors plays an important role in preoperative planning and improving patients' survival rates. The International Ovarian Tumor Analysis (IOTA) group developed a model termed the Assessment of Different NEoplasias in the adneXa (ADNEX). OBJECTIVE: Our objective was to evaluate the performance of the ADNEX model in distinguishing between benign and malignant tumors at a cutoff value of 10%. METHODS: This was a prospective diagnostic study. 357 patients with an adnexal mass who were scheduled for surgery at Siriraj Hospital were included from May 1, 2018, to May 30, 2019. All patients were undergoing ultrasonography, and serum CA125 was measured. Data were calculated by the ADNEX model via an IOTA ADNEX calculator. RESULTS: Of the 357 patients, 296 had benign tumors and 61 had malignant tumors. The area under the receiver operating characteristic curve for using the ADNEX model was 0.975 (95% confidence interval, 0.953-0.988). At a 10% cutoff, the sensitivity was 98.4% and specificity was 87.2%. The best cutoff value was at 16.6% in our population. CONCLUSIONS: The performance of the ADNEX model in differentiating benign and malignant tumors was excellent.