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Int J Pharm ; 498(1-2): 347-54, 2016 Feb 10.
Artículo en Inglés | MEDLINE | ID: mdl-26707411

RESUMEN

Purpose of this study was to investigate the ability of octenyl succinic anhydride (OSA) starch as emulsifier and solid carrier in dry emulsion (DE) and dry suspension (DS) formulations. Fenofibrate (FF) was loaded at lower and higher than its saturation concentration in oil phase to prepare the DE and DS by spray drying method. The DE and DS were successfully prepared with 36-48% and 46% production yield, respectively. After reconstitution in water, the emulsion with mean droplet size of 1-2 µm was obtained. Solid state characterization revealed the amorphous state of FF and the crystalline state of OSA starch in both DE and DS formulations. Both DE and DS enhanced FF dissolution rate compared to pure material and DS showed the highest dissolution rate. The DE and DS could be compressed to the tablets with acceptable disintegration time and without changeable dissolution profile. Moreover, the dissolution profiles of both DE and DS remained unchanged after 2 months storage at 40 °C.


Asunto(s)
Portadores de Fármacos/síntesis química , Emulsionantes/síntesis química , Fenofibrato/síntesis química , Almidón/síntesis química , Anhídridos Succínicos/síntesis química , Química Farmacéutica , Portadores de Fármacos/análisis , Emulsionantes/análisis , Fenofibrato/análisis , Solubilidad , Almidón/análisis , Anhídridos Succínicos/análisis , Suspensiones , Difracción de Rayos X/métodos
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