RESUMEN
The aim of this article was to test time perspective as a moderator of the relationship between pain before surgery and acute postoperative pain. Time perspective (ZTPI) and pain before surgery (SF-MPQ) were assessed pre-operatively in 112 patients. The results suggest that past-negative time perspective and fatalistic perspective are significant moderators of the link between preoperative pain and acute postoperative pain. In a case of weak past-negative perspective and weak present-fatalistic perspective, the relationship between preoperative pain and acute postoperative pain is not significant.
Asunto(s)
Dolor Agudo/psicología , Dimensión del Dolor/métodos , Dolor Postoperatorio/psicología , Periodo Preoperatorio , Actitud Frente a la Salud , Femenino , Humanos , Masculino , Persona de Mediana Edad , Factores de TiempoRESUMEN
BACKGROUND: The aim of this study was to predict acute postsurgical pain and coping with pain following surgery based on preoperative time perspectives. Time perspective is a basic dimension of psychological time. It is a tendency to focus on a particular time area: the past, the present and the future. METHOD: Seventy-six patients completed measures of time perspective and pain 24 h before abdominal surgery. During the 3 days after surgery, measures of pain and coping with pain were completed. RESULTS: We performed hierarchical regression analyses to identify predictors of acute postsurgical pain and how patients cope with it. These analyses suggested that a preoperative past-negative time perspective can be a predictor of postoperative pain level and catastrophizing after surgery. CONCLUSION: The findings of our study indicate the importance of time perspective, especially the past perspective, in dealing with postoperative pain. SIGNIFICANCE: Our research indicates that a preoperative past-negative time perspective is a significant predictor of acute postsurgical pain intensity and the strongest predictor of pain catastrophizing.
Asunto(s)
Abdomen/cirugía , Dolor Agudo/psicología , Adaptación Psicológica/fisiología , Catastrofización/psicología , Dolor Postoperatorio/psicología , Dolor Agudo/diagnóstico , Adolescente , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Dimensión del Dolor , Dolor Postoperatorio/diagnóstico , Estudios Prospectivos , Adulto JovenRESUMEN
Due to the frequency of surgeries, acute postsurgical pain (APSP) is a common problem. However, the role of psychological factors in the experience of this kind of pain has not been well established. In this review, we focused on presurgical psychological factors associated with the experience of APSP. A systematic search of articles was performed using PsycARTICLES, PsycINFO, PubMed, MEDLINE, Scopus, Cochrane and DARE. For each study, we assessed the risk of bias, the level of evidence, the corresponding score points and the degree of association with APSP. Separate meta-analyses were performed for the selected variables. Fifty-three relevant publications were selected. Pain catastrophizing, optimism, expectation of pain, neuroticism, anxiety (state and trait), negative affect and depression were classified as likely associated with APSP. Only one of the analysed psychological variables - locus of control - was recognized as shown unlikely association with APSP. Results of meta-analyses suggested that pain catastrophizing was most strongly linked with APSP. Results of the studies reviewed suggest that patients who do not exaggerate the negative aspects of the situation and who have positive expectation of the future before undergoing surgery report lower levels of APSP than patients who catastrophize pain and expect negative events in the future. An increasing interest in preoperative positive psychological variables has been observed over the last few years in studies of surgical patients. WHAT DOES THIS REVIEW ADD?: Pain catastrophizing, optimism, expectation of pain, neuroticism, anxiety (state and trait), negative affect and depression were classified as likely associated with acute postsurgical pain, and locus of control was classified as unlikely associated with acute postsurgical pain. Anxiety was the psychological variable most frequently measured before surgery. Pain catastrophizing was most strongly linked with acute postsurgical pain.
Asunto(s)
Dolor Agudo/psicología , Dolor Postoperatorio/psicología , Ansiedad/psicología , Catastrofización/psicología , Depresión/psicología , HumanosRESUMEN
OBJECTIVE: Sunitinib is a multiple tyrosine kinase inhibitor (TKI) that exerts anti-tumor and antiangiogenic activity. It is used for the treatment of metastatic gastrointestinal stromal tumours, renal cell carcinoma and pancreatic neuroendocrine tumours. A few studies confirm the anti-tumour activity of sunitinib in brain tumours and uveal melanoma, as well as its efficacy in the reduction of brain metastases of some primary cancers. Therefore, the penetration of sunitinib through the blood-brain barrier (BBB) and blood-aqueous humour barrier (BAB) is an issue of growing interest. The aim of the study was to investigate the influence of the time-of-day administration on the penetration of sunitinib into the cerebrospinal fluid (CSF) and aqueous humour (AH). MATERIALS AND METHODS: The rabbits were divided into two groups: I (control group)--receiving sunitinib at 8 a.m., and II--receiving sunitinib at 8 p.m. Sunitinib was administered p.o. at a single dose of 25 mg. The concentrations of sunitinib and its active metabolite (SU12662) in the plasma, CSF, AH were measured with the validated HPLC-UV method. RESULTS: The plasma AUC0-t for sunitinib in group I was 2051.8 ng × h/mL, whereas in group II it was 3069.3 ng × h/mL. The aqueous humour AUC0-t for sunitinib in thr groups were 43.2 and 76.3 ng × h/mL, respectively. The cerebrospinal AUC0-t for sunitinib in groups I and II were 55.5 and 66.3 ng × h/mL, respectively. CONCLUSIONS: After the evening administration (8 p.m.) the exposure to sunitinib in the rabbits' plasma, AH and CSF was higher than after the morning administration (8 a.m.), but the degree of sunitinib penetration through the BAB and BBB was very low (< 5%) and comparable in both groups.