RESUMEN
The aim of the study was to investigate the effect of a protein restricted diet on renal function and growth of children with chronic renal failure. In a multicentre prospective study 56 children (aged 2-18 years) with chronic renal failure were randomly assigned to the protein restricted (0.8-1.1 g/kg/day) or the control group. All children were followed up by the same paediatrician and dietitian. After a follow up period of three years there was no significant difference in glomerular filtration rate between children on a protein restricted diet and children of the control group. There was no significant difference in weight with respect to height and height SD score between the protein restricted and the control group. Compliance with the protein restricted diet, as indicated by the prospective diet diaries and the serum urea:creatinine ratio, was good. This study shows that children with chronic renal failure do not benefit from a protein restricted diet.
Asunto(s)
Proteínas en la Dieta/administración & dosificación , Fallo Renal Crónico/dietoterapia , Adolescente , Estatura , Peso Corporal , Niño , Preescolar , Creatinina/sangre , Femenino , Estudios de Seguimiento , Tasa de Filtración Glomerular , Humanos , Fallo Renal Crónico/fisiopatología , Glomérulos Renales/fisiopatología , Masculino , Estudios Prospectivos , Factores de TiempoRESUMEN
We assessed the relationship between protein intake (calculated from a 3-day prospective dietary diary) and 24-h urinary urea excretion in 37 children with chronic renal failure. Protein intake was not restricted during the investigation period. The 24-h urinary urea excretion correlated poorly with the protein intake estimated from the dietary diary (r = 0.58). We conclude that although it is common practice to assess compliance with a protein-restricted diet in children with chronic renal failure with a dietary diary and 24-h urinary urea excretion, the value of this assessment is questionable.
Asunto(s)
Proteínas en la Dieta/administración & dosificación , Ingestión de Alimentos , Fallo Renal Crónico/orina , Urea/orina , Adolescente , Niño , Preescolar , Femenino , Humanos , Masculino , Registros Médicos , Cooperación del PacienteRESUMEN
During the period 1979-1986, 167 children with terminal renal failure were treated in 4 dialysis centres for children: 124 of them were treated by haemodialysis, 43 by continuous ambulatory peritoneal dialysis (CAPD). The frequency of CAPD increased during the last few years. This method is suitable for small children. The number of transplantations should be increased. Present facilities cannot deal with the numbers of new patients with terminal renal failure.
Asunto(s)
Fallo Renal Crónico/terapia , Diálisis Peritoneal Ambulatoria Continua , Diálisis Renal , Adolescente , Niño , Preescolar , Humanos , Lactante , Fallo Renal Crónico/epidemiología , Trasplante de Riñón , Países Bajos/epidemiologíaAsunto(s)
Errores Innatos del Metabolismo/diagnóstico , Quinona Reductasas/deficiencia , Biomarcadores/sangre , Preescolar , Consanguinidad , Humanos , Lactatos/sangre , Hígado/enzimología , Masculino , Errores Innatos del Metabolismo/tratamiento farmacológico , Errores Innatos del Metabolismo/genética , Músculos/enzimología , NAD(P)H Deshidrogenasa (Quinona) , Vitamina K/uso terapéuticoRESUMEN
Referring to a patient operated on the third day of life for pyeloureteral stenosis the 'prune belly' syndrome is described. The syndrome is delineated by urinary tract anomalies, undescended testicles and a prune like abdominal wall. Several other anomalies are commonly seen. In this patient the megaureters, the vesicoureteral reflux and megacystis are considered part of the syndrome. The pyeloureteral stenosis was only seen once before in a succumbed newborn.
Asunto(s)
Anomalías Múltiples/diagnóstico por imagen , Síndrome del Abdomen en Ciruela Pasa/diagnóstico por imagen , Sistema Urinario/anomalías , Constricción Patológica/congénito , Humanos , Recién Nacido , Pelvis Renal/anomalías , Masculino , Uréter/anomalías , UrografíaRESUMEN
Short term response to single dose of Captopril has been studied in 7 severely hypertensive children. Blood pressure fell within one hour in patients with a non-hypervolemic state. Longterm treatment (average 19 months) of 5 children with refractory hypertension resulted in a sustained blood pressure control. No side-effects had been observed. It is concluded, that Captopril is useful in children with acute severe hypertension. Longterm treatment should be limited to children with refractory hypertension.