RESUMEN
Transcutaneous electroneurostimulation carried out in 24 patients with phantom pain syndrome completely relieved pain in only 25% of patients. A possible cause of poor efficacy of this method is depletion of the endorphin antinociceptive mechanisms. EEG findings indicated a possibility of objectively controlling the course of analgesia. Specific EEG signs of phantom pain syndrome were distinguished: polymorphism of EEG fluctuations, high-frequency rapid or slow electrical activity of the brain, and paroxysmal activity. Normalization of EEG, i.e. appearance of manifest alpha-rhythm, reduction of the intensities of slow-wave and rapid activities with the relevant spectral changes, are signs of a positive effect of the analgesic method used, as exemplified by transcutaneous electroneurostimulation.
Asunto(s)
Miembro Fantasma/terapia , Estimulación Eléctrica Transcutánea del Nervio , Ritmo alfa , Encéfalo/fisiopatología , Electroencefalografía , Endorfinas/sangre , Estudios de Evaluación como Asunto , Humanos , Miembro Fantasma/sangre , Miembro Fantasma/fisiopatología , SíndromeRESUMEN
The changes of phospholipid fatty acid composition of the viscera were investigated in a model of aconitinic arrhythmia in rats by the GC method. Aconitinic arrhythmia leads to a reduction in a proportion of polyenic fatty acids (arachidonic, docosahexaenoic) and to an increase in that of saturated acids (palmitic and stearic acids) in visceral phospholipids as a result of developed respiratory and circulatory hypoxia and to activation of lipid peroxidation. The most hypoxia-sensitive are phospholipids of the heart and brain, the least are renal phospholipids. The ratio of saturated to polyunsaturated fatty acids is the most informative value of lipid peroxidation in aconitinic arrhythmia.
Asunto(s)
Arritmias Cardíacas/metabolismo , Modelos Animales de Enfermedad , Ácidos Grasos/metabolismo , Fosfolípidos/metabolismo , Aconitina , Animales , Arritmias Cardíacas/inducido químicamente , Ácidos Grasos/análisis , Fosfolípidos/análisis , Ratas , Ratas WistarRESUMEN
The well-known phenomenon of incrementing muscular contraction intensity induced by an increased ambient pressure is still unclear (P. Regnard, 1891). This study was done in order to establish whether an increased contraction intensity is the result of enhanced effect of triggering stimuli in response to pressure elevation to 100 atm or a rise in muscle contraction intensity depends on other reasons. When studying the nerve stimulation electric response (muscle action potential, MAP) at increased pressure, the MAP amplitude significantly decreased about two-fold whereas the contraction intensity increased two-fold. The response duration was also elevated. Since electric stimulation was supramaximal in an intensity throughout the experiment the contraction-generating nervous impulse was sufficient for stimulating all the muscle fibers. No significant changes in other parameters of electric potentials occurring during neuromuscular transmission under pressure have been found which agrees with available neurophysiologic data. Thus, the causes responsible for an increased contraction intensity appear to depend on an altered muscle fiber contractility. This phenomenon provides the basis for understanding the changes in peripheric structures of the body and the periphery contribution to the genesis of hyperbaric nervous syndrome.