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Allogeneic bone marrow transplantation (BMT) from an HLA-identical sibling donor is effective therapy for patients with bone marrow failure states and those with hematologic malignancies. However, only a minority of them will have an HLA-identical sibling donor; unrelated donors, matched or partially mismatched, have been used successfully for patients lacking a related donor. Even though results with allogeneic transplants using unrelated donors are encouraging, the incidence of complications including graft-versus-host disease (GVHD) and graft rejection or late graft failure is increased compared to identical sibling transplants. The combination of cyclophosphamide and total body irradiation (TBI) has been used as an effective preparative regimen for allogeneic transplants, however, the total dosage and dosing schedule of both the cyclophosphamide and TBI has varied significantly among studies. To decrease the rate of graft rejection and late graft failure with volunteer donors, we evaluated a preparative regimen of high-dose cyclophosphamide (200 mg/kg over 4 consecutive days, days -8, -7, -6, -5) followed by fractionated TBI (1400 cGy administered in eight fractions over 4 days, days -4, -3, -2, -1). GVHD prophylaxis included FK506 and methotrexate. From July 1993 to January 1996, 43 adult patients, median age 38 years (range 18-58 years), were treated with this preparative regimen. Seventeen patients had low-risk disease and 26 had high-risk disease. Thirty-one donor/recipient pairs were matched for HLA-A, -B, and -DR by serology and molecular typing. Seven additional pairs were minor mismatched at the HLA-A or HLA-B loci. Four other donor/recipient pairs were HLA-A,-B, and -DR identical by serology but allele mismatched at either DRB1 or DQB. Forty patients were evaluable for myeloid engraftment. Engraftment occurred in all 40 patients at a median of 19 days. There were no cases of graft rejection or late graft failure. Nephrotoxicity was the primary adverse event with 26 patients (60%) experiencing a doubling of their creatinine. Hepatic veno-occlusive disease occurred in seven patients, six of whom had high-risk disease. All patients who had relapsed or refractory disease prior to BMT achieved a complete remission following BMT. Six patients transplanted for high-risk disease relapsed a median of 377 days post-BMT. None of the patients with low-risk disease have relapsed following transplant; the Kaplan-Meier survival for those patients with low-risk disease is 62% and 37% for those patients transplanted with high-risk disease (P = 0.0129). The median Karnofsky performance status is 100% (range 70-100%). Therefore, a preparative regimen of high-dose cyclophosphamide and fractionated TBI is an acceptable regimen for patients receiving an allograft from unrelated donors.

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Force transmission onto implants supporting overdentures was measured in vivo by means of piezoelectric transducers that allow for simultaneous force registrations in 3 dimensions. The transducers are directly mounted onto the implants, beneath the anchorage device. The force registrations were analyzed with regard to the anchorage device and retention mechanism of overdenture support. The 3 types of denture anchorage were a U-shaped bar, a round clip-bar and single telescopes. Forces were measured in the following test situations: maximum force when biting in centric occlusion, maximum bite force during biting on a bite plate, grinding and chewing bread. Multiple regression showed that the vertical component of maximum forces was dependent on the anchorage device and test situation. The transverse components reached 10 to 50% of the vertical force magnitude. With the bite plate in situ maximum forces measured in vertical direction were significantly higher or the ipsilateral implant with telescopes than with bars (p < 0.01 and p < 0.001). Chewing and grinding resulted in lower vertical forces compared to maximum biting. In transverse dimensions, mainly in the anterior-posterior direction, registered forces reached magnitudes that resembled the vertical component (50 to 100%). Force magnitudes of chewing and grinding were similar for all three anchorage devices. However, differences were observed between bars and telescopes with regard to the direction of transverse force components. The results of this study do not suggest the preference of one specific anchorage system or retention mechanism for overdenture support. However, rigid bars contribute to load sharing and stress distribution onto the implants.

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