RESUMEN

Several phenotypic changes have been shown to occur after NK-cell stimulation, involving molecules that have been proved to regulate NK-cell migration into tissues and NK-cell activation and proliferation as well as target cell recognition and killing. Here, we review the reactive phenotypes observed in vivo after acute and chronic NK-cell activation.

Asunto(s)

Inmunofenotipificación , Células Asesinas Naturales/inmunología , Activación de Linfocitos , Antígeno CD56/análisis , Humanos , Linfocitos T/inmunología

RESUMEN

In this paper we report a rare association of a splenic marginal zone B-cell lymphoma with villous lymphocytes and a T-cell large granular lymphocytic leukemia coexpressing CD4 and CD8 as well as CD56 and CD57 natural killer-associated markers in an asymptomatic patient investigated because of an occasional finding of erythrocytosis and leukocytosis in routine blood analysis. We also discuss the possible reasons for this particular association.

Asunto(s)

Leucemia de Células T/complicaciones , Linfoma de Células B/complicaciones , Neoplasias Primarias Múltiples/complicaciones , Policitemia/complicaciones , Anciano , Células Sanguíneas/patología , Antígenos CD4/análisis , Antígeno CD56/análisis , Antígenos CD57/análisis , Antígenos CD8/análisis , Reordenamiento Génico de Linfocito B , Reordenamiento Génico de Linfocito T , Humanos , Inmunofenotipificación , Leucemia de Células T/clasificación , Leucemia de Células T/diagnóstico , Linfocitos/patología , Linfoma de Células B/diagnóstico , Linfoma de Células B/genética , Masculino , Neoplasias Primarias Múltiples/diagnóstico , Neoplasias Primarias Múltiples/genética , Bazo/patología