RESUMEN

A diverse set of techniques (curiosity, chimney test, changes in barbiturate-induced sleep time, spontaneous motor activity, swimming ability, body temperature) was used to study theophylline (T)-induced changes in CNS etilefrine (E). T antagonized the depressive effects produced by high doses of E. Nevertheless, the LD50 of E was not modified when both drugs were administered simultaneously.

Asunto(s)

Sistema Nervioso Central/efectos de los fármacos , Etilefrina/farmacología , Teofilina/farmacología , Animales , Conducta Animal/efectos de los fármacos , Interacciones Farmacológicas , Etilefrina/toxicidad , Femenino , Masculino , Ratones , Ratas , Ratas Wistar