Asunto(s)
Yeyuno/fisiología , Inhibidores de la Lipooxigenasa , Pulmón/fisiología , Contracción Muscular/efectos de los fármacos , Bases de Schiff/farmacología , Animales , Antígenos/inmunología , Cobayas , Yeyuno/inmunología , Pulmón/inmunología , Masoprocol/farmacología , Ovalbúmina/inmunología , SRS-A/farmacología , Bases de Schiff/química , Relación Estructura-ActividadRESUMEN
Different types of anti-allergic agents have been compared for their ability to inhibit the antigen-induced contraction of isolated lung parenchymal strips and ilea of guinea pigs. Extremely low concentrations of the lipoxygenase inhibitor NDGA inhibit the contraction of the lung parenchymal strips and higher concentrations block the ileal phase II-contraction (both predominantly caused by the developing SRS-A), but do not inhibit ileal phase I-contraction (caused by released histamine). The H1-antihistamine clemastine predominantly antagonizes phase I of the ileum contraction, and the anti-allergic drug oxatomide reduces all three types of contraction. The degranulation inhibitor DSCG does not influence the contraction of the lung strip, but produces a slight inhibition of both ileal contractions. The PAF-antagonist BN 52021 influences these three contractions in the opposite way to DSCG. As these various types of anti-allergic agents influence these three contractions in a different manner, the models can be used for judging the mechanism of action of a new anti-allergic compound.
Asunto(s)
Antígenos/inmunología , Diterpenos , Íleon/inmunología , Pulmón/inmunología , Animales , Clemastina/farmacología , Cromolin Sódico/farmacología , Ginkgólidos , Cobayas , Íleon/efectos de los fármacos , Íleon/fisiología , Técnicas In Vitro , Lactonas/farmacología , Pulmón/efectos de los fármacos , Pulmón/fisiología , Masculino , Masoprocol/farmacología , Contracción Muscular/efectos de los fármacos , Piperazinas/farmacologíaRESUMEN
Derivatives substituted at position 2 of 4-oxochinazolin as well as derivates of oxochinazolin-3-yl-benzoic acid and 4-oxochinazolin-3-yl-acetic acid had been tested for their antianaphylactic activities in the passive (PCA) and/or active cutaneous anaphylaxis (ACA) in rats. At i.p. administration (ACA) or intracutaneous (i.c.) administration (PCA) most of the derivates displayed a moderate antianaphylactic activity which et best could be compared to the theophylline activity. Only the free acids of the 4-oxochinazolin-3-yl-acetic acid derivatives were active at i.c. administration. All compounds tested remained inactive at p.o. administration.