Asunto(s)
Heroína/efectos adversos , Hipertensión Pulmonar/etiología , Trastornos Relacionados con Opioides/complicaciones , Adulto , Femenino , Francia/epidemiología , Humanos , Hipertensión Pulmonar/epidemiología , Incidencia , Masculino , Persona de Mediana Edad , Narcóticos/efectos adversos , Trastornos Relacionados con Opioides/epidemiología , Factores de RiesgoRESUMEN
Sarcoidosis and Crohn's disease are systemic granulomatous disorders affecting the lung and the intestine, respectively, with variable involvement of other organs and are seldom associated. While anti-TNF α is a recognized treatment of Crohn's disease, its usage is discussed in sarcoidosis. A 42-year-old man presented with an 11-year-long history of Crohn's disease; upon discovery of an abnormal chest CT scan the diagnosis of multivisceral sarcoidosis was made and, later, a treatment with an anti-TNF α agent, infliximab, was started, because of worsening Crohn's disease recurrences. CT scan demonstrated net regression of pulmonary opacities and hepatosplenic lesions. Pathologies obtained from the intestinal tract and the bronchi of the patient were, respectively, characteristic of Crohn's disease and sarcoidosis leading to the diagnosis of both diseases. We report a rare case of steroid resistant Crohn's disease associated with multivisceral sarcoidosis, treated successfully by an anti-TNF α agent, infliximab.
Asunto(s)
Hematopoyesis Extramedular , Granuloma de Células Plasmáticas del Pulmón/diagnóstico por imagen , Talasemia beta , Anciano , Diagnóstico Diferencial , Humanos , Masculino , Radiografía Torácica , Esplenectomía , Talasemia beta/complicaciones , Talasemia beta/fisiopatología , Talasemia beta/cirugíaRESUMEN
Urachal adenocarcinoma is a rare neoplasm of the bladder. Most of these tumors arise from urachal remnants in the dome of the bladder and extend into the umbilicus. These tumors can recur and most commonly metastasize to lymph nodes, retroperitoneum, lungs, liver and bone. Here we report a case of an urachal adenocarcinoma followed for seven years with lung metastasis for three years.
RESUMEN
Surgery is the standard treatment of early-stage non-small cell lung cancer (NSCLC). However, all patients do not undergo radical resection because of the very frequent co-morbidities occurring in smokers. Recently, new therapeutic options have emerged for limited-size (less than 4 cm) NSCLC tumors. Stereotactic radiotherapy consists of the use of multiple radiation micro-beams, allowing high doses of radiation to be delivered to the tumor in a small number of fractions. Radiofrequency ablation delivers high frequency electromagnetic waves through a needle-like probe, that produces ionic agitation, increase of the temperature in the tumor tissue, and ultimately leads to coagulation necrosis of the tumor. Several studies have been reported, that show the efficacy of these treatment modalities to control stage I/II NSCLC in medically inoperable patients. Local control rates are consistently reported to be above 90 %. Stereotactic radiation therapy and radiofrequency ablation are now being evaluated prospectively; namely, stereotactic radiotherapy is being compared to surgery in operable patients in several randomized trials. Overall, from a technical concept to the availability of specific treatment devices and the publication of clinical results, stereotactic radiotherapy and radiofrequency ablation are paradigms of implementation in thoracic oncology.