RESUMEN
The medical plant research has received more attention among researchers especially after the Covid-19 pandemic. This research performed to evaluate the antifungal, anti-lung cancer (A549), and anti-hyperglycemic activities of aqueous extract of Andrographis paniculata flower. Interestingly, A. paniculata flower aqueous extract contains pharmaceutically valuable phytochemicals such as alkaloid, phenolics, terpenoids, tannins, flavonoids, and protein. It also showed fine antifungal activity against test fungal pathogens in the following order as: Aspergillus niger > Fusarium solani > Trichoderma harzianum > A. parasiticus > P. expansum > Penicillium janthinellum with lowest MIC values as ranged from 100 to 300 µg mL-1. Interestingly, this aqueous extract also showed considerable anti-lung cancer activity, evidenced by dose and time dependent lung cancer cell line (A549) growth/proliferation inhibition/cytotoxicity activity (65%) at 300 µg mL-1 concentration. This can be achieved by plant extract through inducing the secretion of apoptosis related proteins such as TNF α, IFN-γ, and interleukin 2 leads to apoptosis in A549 cells. It also showed fine anti-diabetic activity by inhibiting α -amylase (58.41%) than α-glucosidase (54.74%) at 200 µg mL-1 concentration. The UV as well as FTIR results demonstrated that the aqueous extract of A. paniculata flower contains pharmaceutically valuable bioactive compounds, which may be responsible for the wide range of biomedical applications.
Asunto(s)
Andrographis , Antifúngicos , Humanos , Antifúngicos/química , Antifúngicos/farmacología , Andrographis paniculata , Pandemias , Andrographis/química , Flores , Agua , Hipoglucemiantes/farmacologíaRESUMEN
Phytosanitary concerns are part of today's agricultural environment. The use of chemicals to treat plant diseases is both a source of pollution and allows pathogens to become resistant. Additionally, it can improve the chemical, physical, and biological properties of soil. Therefore, the soil environment is more conducive to healthy plant growth. By improving the chemical, physical, and biological attributes of soil, biochar can enhance plant resistance. Agricultural success has been attributed to biochar's acidic pH, which promotes beneficial soil microorganisms and increases soil nutrients; it is also porous, which provides a home and protects soil microorganisms. By improving soil properties, biochar becomes even more effective at controlling pathogens. The article also discusses the benefits of biochar for managing pathogens in agricultural soils. In addition, we examine several research papers that discuss the use of biochar as a method of combating soil-related pathogens and plant diseases. Biochar can be used to combat soil-borne diseases and other conditions.
Asunto(s)
Carbón Orgánico , Suelo , Agricultura , Nutrientes , Plantas , Suelo/químicaRESUMEN
In the recent years, plant and microbial extract based nanoparticles (NPs) have become a sophisticated technology serving as an alternative strategy for the purpose of developing materials functionalized by structural diversity and enhanced energy efficiencies. Cobalt oxide nanoparticles (GCoO-NPs) have wide applications in several sectors due to their high resistance to corrosion as well as oxidation, ecofriendly nature, cost effectiveness and nontoxic potential. Plant based particles are credible alternatives as they reduce the burden of complicated and laborious protocols of physiochemical reliance. In this study, GCoO-NPs were synthesized using the grape Jumbo Muscadine (Vitis rotundifolia) using co-precipitation. The synthesized GCoO-NPs were characterized by UV-Vis spectrophotometer, Fourier transform infrared spectroscopy (FTIR), Powder X-ray diffraction (PXRD) and Scanning electron microscopy (SEM). The photocatalytic activity of the GCoO-NPs was estimated by the degradation of Acid Blue-74 (AB-74) dye and the complete degradation of 98% was accomplished at the reaction time of 150 min at pH 10 and 60 mg/100 mL concentration. The outcomes of this study indicated the excellent performance of the GCoO-NPs on par with some of the earlier findings and this can be an appealing aspirant of extreme potential to be employed as a catalyst alternative to the conventional wastewater treatment methods.