RESUMEN

A novel influenza A(H1N1)2009 variant with mildly reduced oseltamivir and zanamivir sensitivity has been detected in more than 10% of community specimens in Singapore and more than 30% of samples from northern Australia during the early months of 2011. The variant, which has also been detected in other regions of the Asia-Pacific, contains a S247N neuraminidase mutation. When combined with the H275Y mutation, as detected in an oseltamivir-treated patient, the dual S247N+H275Y mutant had extremely high oseltamivir resistance.

Asunto(s)

Subtipo H1N1 del Virus de la Influenza A/genética , Gripe Humana/epidemiología , Gripe Humana/genética , Neuraminidasa/genética , Oseltamivir/uso terapéutico , Polimorfismo de Nucleótido Simple/genética , Zanamivir/uso terapéutico , Antivirales/uso terapéutico , Australia/epidemiología , Resistencia a Medicamentos/genética , Predisposición Genética a la Enfermedad/epidemiología , Predisposición Genética a la Enfermedad/genética , Variación Genética/genética , Humanos , Incidencia , Gripe Humana/tratamiento farmacológico , Neuraminidasa/antagonistas & inhibidores , Vigilancia de la Población/métodos , Medición de Riesgo , Factores de Riesgo , Singapur/epidemiología