Asunto(s)
Infecciones Oportunistas Relacionadas con el SIDA/microbiología , Angiomatosis Bacilar/microbiología , Bartonella/aislamiento & purificación , Infecciones por VIH/inmunología , Huésped Inmunocomprometido , Piel/microbiología , Infecciones Oportunistas Relacionadas con el SIDA/tratamiento farmacológico , Infecciones Oportunistas Relacionadas con el SIDA/inmunología , Infecciones Oportunistas Relacionadas con el SIDA/patología , Angiomatosis Bacilar/tratamiento farmacológico , Angiomatosis Bacilar/inmunología , Angiomatosis Bacilar/patología , Antibacterianos/uso terapéutico , Bartonella/efectos de los fármacos , Biopsia , Infecciones por VIH/diagnóstico , Humanos , Masculino , Piel/efectos de los fármacos , Piel/patología , Resultado del Tratamiento , Adulto JovenRESUMEN
BACKGROUND: While basal cell carcinoma (BCC) remains the most common skin cancer, the incidence of metastasis is rare. Most cases of metastatic BCC have been to regional lymph nodes. Metastasis to bone marrow with myelophthisic anemia is especially rare. To our knowledge, there have been only 5 reported cases in literature. We report a sixth case. OBSERVATIONS: A 46-year-old male patient presented with an 8 × 7-cm ulcerated plaque on his chest, found to be morpheaform basal cell on pathology. Laboratory findings were notable for normocytic anemia, thrombocytopenia, and elevated LDH. Further work up with bone marrow biopsy revealed tumor cells staining positive for CK AE1/AE3, BerEP4, CK7, CD56, and PIN-4. This confirmed the diagnosis of metastatic BCC (MBCC) to bone marrow. CONCLUSIONS: Although the rate of metastasis for BCC is rare, once it occurs, prognosis is poor. MBCC remains a challenge to treat. Therefore, it is critical to resolve the primary BCC and obtain vigilant follow-up, especially in patients with multiple risk factors for MBCC.
Asunto(s)
Anemia Mielopática/etiología , Neoplasias de la Médula Ósea/complicaciones , Neoplasias de la Médula Ósea/secundario , Carcinoma Basocelular/secundario , Neoplasias Cutáneas/patología , Humanos , Masculino , Persona de Mediana EdadRESUMEN
Morphea, also known as localized scleroderma, is characterized by firm plaques that can occur anywhere on the body. Reports of familial morphea are rare, and we report an unusual case of morphea affecting both a father and a son.
Asunto(s)
Esclerodermia Localizada/genética , Esclerodermia Localizada/patología , Piel/patología , Adulto , Niño , Padre , Humanos , Hiperpigmentación/genética , Hiperpigmentación/patología , Masculino , Núcleo FamiliarRESUMEN
Loose anagen hair syndrome (LAHS) is a condition of sparse, short hair that is easily and painlessly extracted from the scalp. Since it was first described in the 1980s, it is considered a rare, sporadic condition found predominantly in females. Since then, there have been multiple reports of LAHS occurring in families, suggesting an autosomal dominant inheritance pattern may also be present. An autosomal dominant trait would suggest a more equal sex ratio. We report a case of a boy diagnosed with LAHS and propose that it may be underdiagnosed in males simply because of hairstyle differences between boys and girls.