RESUMEN
Environmental threats increasingly entail important risks from government responses. In considering the risks of a new vector-borne disease, for example, decision-makers must also grapple with potential risks from responses such as the aerial spraying of pesticides. In communicating about these complex risks, public officials often choose different "frames" that promote different conceptualizations of the issue. Yet prior research has paid limited attention to how public officials frame the related risks of the environmental threat and the public response. This paper starts to fill that gap by conducting a content analysis of statements by public officials regarding risks from the threat of a local outbreak of the Zika virus in South Florida in 2016, as well as risks from the response of aerial pesticide spraying. Based on limited prior research, we hypothesize that public officials are likely to have adopted a "risk maximization" frame that stressed the high risks from exposure to Zika, but a "risk trade-off" frame when discussing aerial spraying. In actuality, we find that officials strongly favored a "reassurance" frame that downplayed both types of risks. Based on this analysis, we suggest framing strategies for disease outbreaks and other threats with potentially risky government responses may vary significantly depending on local contexts and that the South Florida experience was a missed opportunity to test the strategy of trade-off framing.
RESUMEN
When point clouds are labeled in information visualization applications, sophisticated guidelines as in cartography do not yet exist. Existing naive strategies may mislead as to which points belong to which label. To inform improved strategies, we studied factors influencing this phenomenon. We derived a class of labeled point cloud representations from existing applications and we defined different models predicting how humans interpret such complex representations, focusing on their geometric properties. We conducted an empirical study, in which participants had to relate dots to labels in order to evaluate how well our models predict. Our results indicate that presence of point clusters, label size, and angle to the label have an effect on participants' judgment as well as that the distance measure types considered perform differently discouraging the use of label centers as reference points.
Asunto(s)
Gráficos por Computador , Imagenología Tridimensional , Estimulación Luminosa , Adulto , Femenino , Humanos , Masculino , Modelos Teóricos , Proyectos Piloto , Percepción Visual , Adulto JovenRESUMEN
BACKGROUND: Silicosis features foci of inflammation where macrophages and lymphocytes precede and accompany fibroblast proliferation, alveolar epithelial hyperplasia, and increased deposition of connective tissue matrix material. In the mouse following silica inhalation there is recruitment of natural killer-, B-, and CD4+ and CD8+ lymphocytes to the alveolar spaces, enlargement of bronchial-associated lymphoid tissues (BALT), and aggregation of lymphocytes surrounding small airways and blood vessels. A substantial fraction of the recruited lung lymphocytes produce interferon-gamma (IFN-gamma), and IFN-gamma gene-deleted mice develop less silicosis than wild-type mice. Interleukin-12 (IL-12) is an important pathway for driving the adaptive immune response towards a TH1-like phenotype. We hypothesized that IL-12 might stimulate lymphocyte activation and the up-regulation of IFN-gamma, and consequently be an essential mediator for silicosis. RESULTS: C57Bl/6 wild-type (WT) and IL-12 deficient (IL-12 KO) mice were exposed to sham-air or crystobalite silica (61 mg/m3) by inhalation for 5 hours/day for 12 days and then studied from 1 to 112 days after exposure. Mice exposed to sham-air had normal lung histology at all time points. WT mice exposed to titanium dioxide (72 mg/m3) showed pulmonary macrophage recruitment but no increase in lung collagen. Both WT and IL-12 KO mice exposed to silica showed similar progressive lung pathology, increased wet lung weight and increased total lung collagen (hydroxyproline). IL-12 p35 mRNA was not increased in either strain after silica exposure; IL-12 p40 mRNA was up-regulated after silica in WT mice and constitutively absent in the IL-12 KO mice. IL-18 mRNA was not increased after silica exposure. The expression of IL-15 (an important driver for innate immunity, Natural Killer cell activation, and IFN-gamma production) was abundant in air-exposed mice and was increased slightly in the lungs of mice with silicosis. CONCLUSION: The axis of IL-12 driving IFN-gamma production is not essential for the full manifestations of silicosis in mice exposed to a crystobalite silica aerosol.