RESUMEN
In villages with endemic nephropathy (EN) high incidence and mortality rates of some urinary system tumors are reported. Age-adjusted incidences of renal pelvic and ureteral neoplasms were 46/10(5) in females and 27/10(5) in males; for urinary bladder tumors these figures were 16/10(5) and 35/10(5). The frequency of parenchymal kidney tumors was similar to that reported for the country as a whole. An increased relative risk of developing urinary system tumors was observed in patients with EN and with advancing age (only in women). Smoking did not relate to the occurrence of these neoplasms. No tumors of the urinary system were found in the investigated farm and domestic animals from the endemic region.
Asunto(s)
Nefritis Intersticial/epidemiología , Neoplasias Urogenitales/epidemiología , Animales , Bulgaria , Femenino , Humanos , Neoplasias Renales/epidemiología , Pelvis Renal , Masculino , Mapas como Asunto , Riesgo , Población Rural , Fumar/complicaciones , Neoplasias Ureterales/epidemiología , Neoplasias de la Vejiga Urinaria/epidemiología , Neoplasias Urogenitales/mortalidad , Neoplasias Urogenitales/veterinariaRESUMEN
Data on the occurrence of endemic nephropathy (EN) and urinary tract and other cancers in an endemic region of Vratza district, Bulgaria, for the years 1965-1974, are presented. In endemic villages a high incidence of urinary tract tumours, affecting in particular the renal pelvis and ureter, closely correlated with the EN incidence and mortality rates. In the villages with high and moderate EN incidences urinary tract tumours are the most common neoplasms. They account for 25% of all tumour sites in males and 30% in females. In hyperendemic villages age-adjusted incidences in EN and urinary tract tumours were 506/10(5) and 104/10(5) in females, and 315/10(5) and 89/10(5) in males respectively. EN mortality in these villages accounted for over 40% of all deaths in females and about 30% in males. Both diseases displayed peculiar geographic clustering. Females and middle-aged persons were most often affected. Urinary tract neoplasms were often multiple and nearly 90% of them originated in the uro-epithelium. In endemic and non-endemic villages of the region studied, the frequency and pattern of non-urinary tract cancers were rather similar, with statistical values close to those of the rural population of Vratza District and Bulgaria as a whole.
Asunto(s)
Enfermedades Renales/epidemiología , Neoplasias Urogenitales/epidemiología , Adolescente , Adulto , Factores de Edad , Anciano , Bulgaria , Niño , Preescolar , Femenino , Humanos , Enfermedades Renales/complicaciones , Enfermedades Renales/mortalidad , Neoplasias Renales/epidemiología , Masculino , Persona de Mediana Edad , Población Rural , Factores Sexuales , Neoplasias Urogenitales/complicaciones , Neoplasias Urogenitales/mortalidadRESUMEN
Cancer mortality in endemic and non-endemic villages from a region with endemic nephropathy (EN) of Vratza district, Bulgaria has been compared for the period 1965--1974. The total and for all cancer sites mortality rates in all studied villages were comparable to European and world standards except a very high mortality from tumors of urinary organs in the endemic villages. Age-adjusted to world population rates/10(5) population in hyperendemic villages have been estimated as 16.8 for males and 14.9 for females in case of kidney tumors and as 7.1 in males and 10.2 for females in case of urinary bladder tumors. On village group basis a very close correlation between mortality rates from urinary system tumors and EN incidence rates has been disclosed although endemic and non-endemic villages are neighbouring and are very similar in ecological and cultural terms.