RESUMEN
In 43 carriers of toxigenic C. diphtheriae the antigenic picture of lymphocyte membranes was studied by the method of flow cytofluorometry. The study revealed that at the time of the hospitalization of the carriers a decrease in the number of CD21+ and HDL-DR+ lymphocytes was a prognostically important criterion for the formation of carrier state, while a decrease in the content of natural killers (CD16+) was characteristic of prolonged forms of carrier state. The necessity of the study of cellular immunity factors in carriers at the time of their hospitalization and the expediency of the inclusion of immunocorrective therapy into the individual schemes of their treatment were substantiated.
Asunto(s)
Portador Sano/inmunología , Difteria/inmunología , Subgrupos Linfocitarios/inmunología , Adulto , Antígenos CD/sangre , Enfermedad Crónica , Toxina Diftérica , Femenino , Citometría de Flujo , Antígenos HLA-DR/sangre , Humanos , Inmunidad Celular , MasculinoRESUMEN
Changes in the deformability of erythrocytes in patients with toxic forms of diphtheria were studied. The study was carried out by the filtration method every 7-10 days (starting from the day of hospitalization and until discharge). The evaluation of the results obtained in this study revealed that in patients with toxic forms of diphtheria the deformability of erythrocytes decreased in comparison with the control group. The early restoration of the deformability of erythrocytes in patients with toxic forms of diphtheria made it possible to prognosticate the favorable course of the disease. The prolonged absence of the restoration of the deformability of erythrocytes was observed in severe forms of myocarditis and pneumonia, which was prognostically unfavorable.
Asunto(s)
Difteria/sangre , Deformación Eritrocítica , Enfermedad Aguda , Adolescente , Adulto , Difteria/complicaciones , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pronóstico , Factores de TiempoRESUMEN
High incidence of diphtheria became a pressing problem in recent years. The age structure of patients has changed. A specific feature of diphtheria in adults is a high share of toxic forms and a higher incidence of grave combined forms and rare localizations of the disease focus. The oral cavity proper is one of rare localizations of this infection. The authors examined 12 patients in whom the process was localized in various parts of the buccal mucosa: on the upper and lower lips, on the hard and soft palate, on the cheeks and tongue. Morphologic disturbances presenting as necrosis and inflammatory infiltration were detected in sites involved in the diphtheritic process. Changes whose manifestation was related to the diseases severity were found in zones adjacent to the foci. The authors come to a conclusion on a higher incidence of heretofore rare localizations of diphtheria than previously, this making difficult the diagnosis and treatment of the disease.
Asunto(s)
Difteria/diagnóstico , Enfermedades de la Boca/diagnóstico , Adulto , Anciano , Anciano de 80 o más Años , Diagnóstico Diferencial , Difteria/patología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Enfermedades de la Boca/patología , Mucosa Bucal/patologíaAsunto(s)
Granulocitos/inmunología , Infecciones Estreptocócicas/inmunología , Tonsilitis/inmunología , Enfermedad Aguda , Adolescente , Adulto , Actividad Bactericida de la Sangre/inmunología , Convalecencia , Femenino , Humanos , Masculino , Neutrófilos/inmunología , Infecciones Estreptocócicas/diagnóstico , Tonsilitis/diagnósticoAsunto(s)
Meningitis Meningocócica/diagnóstico , Infecciones Oportunistas/diagnóstico , Enfermedad Aguda , Anticuerpos Antibacterianos/análisis , Humanos , Tolerancia Inmunológica/inmunología , Lactante , Masculino , Meningitis Meningocócica/etiología , Meningitis Meningocócica/inmunología , Neisseria meningitidis/inmunología , Neisseria meningitidis/patogenicidad , Infecciones Oportunistas/etiología , Infecciones Oportunistas/inmunologíaRESUMEN
The presence of antibodies to meningococci has been determined in the sera of 203 patients with meningococcal infection and 234 healthy persons by means of the indirect hemagglutination tests with the use of polyvalent erythrocyte diagnosticum. The tests have shown that antibodies to cross-reacting antigens can be detected both in patients with generalized forms of meningococcal infection and in healthy persons; the level and occurrence of these antibodies depend on the age of the subjects under examination and the form taken by the course of meningococcal infection. The study has revealed that the background level of antibodies to meningococci in healthy persons is mainly formed due to meningococcal carriership. Antibodies to cross-reacting meningococcal antigens have been shown to be capable of being transferred transplacentally.
Asunto(s)
Anticuerpos Antibacterianos/análisis , Antígenos Bacterianos/análisis , Meningitis Meningocócica/inmunología , Neisseria meningitidis/inmunología , Sepsis/inmunología , Adulto , Portador Sano/inmunología , Niño , Preescolar , Reacciones Cruzadas , Epítopos/análisis , Pruebas de Hemaglutinación/métodos , Humanos , Lactante , Recién Nacido , Nasofaringitis/inmunología , Especificidad de la EspecieRESUMEN
Local and humoral immunity factors have been studied in 152 patients with different forms of meningococcal infection. The peculiar pattern of the time course of changes in these factors, depending on the clinical form of the disease, has been revealed. In the generalized form of infection changes in the immunological characteristics of the saliva and blood serum (lysozyme, secretory immunoglobulin, immunoglobulins of the main classes and specific antimeningococcal antibodies) have been shown to be more essential than in the localized form.