RESUMEN
A total of 3194 cases of enterovirus meningitis were notified in the Russian Federation in 2005, of them there were 1434 cases in the Khabarovsk Territory. Enteroviruses were isolated from 1020 out of the virologically studied 1362 patients from the Khabarovsk Territory. Viruses E6 and E30 were isolated in 80 and 14.7% of cases, respectively. E1, E3, E7, E33, Coxsackie virus B1, B4, B5, and A10 were sporadically detected. The E6 strains isolated in Komsomolsk-on-Amur were identical while E6 strains isolated in Khabarovsk belonged to two different genotypes and greatly differed from those isolated in Konsomolsk-on-Amur. The virus E30 strains isolated in Khabarovsk and Komsomolsk-on-Amur had a 1% difference in VP1 genome nucleotide sequence and belonged to E30 subtype that circulated in Russia and Kazakhstan in 2004-2005.
Asunto(s)
Infecciones por Echovirus/epidemiología , Enterovirus Humano B/genética , Meningitis Aséptica/epidemiología , Epidemiología Molecular , Enterovirus Humano B/clasificación , Genoma Viral/genética , Humanos , Filogenia , Siberia/epidemiologíaRESUMEN
Results of epidemiologic, virologic, and serologic studies of enterovirus infections in Khabarovsk region from 1975 to 2006 were analyzed. Patterns of epidemic process of these infections were established: periodic change of dominating type of pathogen in the population; onset of the large epidemic peaks of incidence during emergence of circulation of new for the given area serotypes of enteroviruses; possibility of realization of several routes of virus transmission. Role of water factor in the progress of the epidemic process was revealed. Etiology of the large epidemic rise of aseptic meningitis incidence in Khabarovsk region in 2006 was established--the leading pathogens were ECHO viruses serotypes E6 and E30.
Asunto(s)
Brotes de Enfermedades , Infecciones por Enterovirus/epidemiología , Meningitis Aséptica/epidemiología , Anticuerpos Antivirales/sangre , Notificación de Enfermedades , Enterovirus/clasificación , Enterovirus/genética , Enterovirus/inmunología , Enterovirus/aislamiento & purificación , Infecciones por Enterovirus/sangre , Infecciones por Enterovirus/virología , Humanos , Incidencia , Meningitis Aséptica/sangre , Meningitis Aséptica/virología , Pruebas de Neutralización , Estudios Retrospectivos , Factores de Riesgo , Estaciones del Año , Siberia/epidemiología , Microbiología del AguaAsunto(s)
Infecciones por Adenoviridae/prevención & control , Infecciones por Enterovirus/prevención & control , Microbiología Ambiental , Aguas del Alcantarillado/virología , Adenoviridae/aislamiento & purificación , Enterovirus/aislamiento & purificación , Humanos , Federación de Rusia , Estaciones del Año , Aguas del Alcantarillado/análisisRESUMEN
The etiological investigation of an epidemic outbreak of aseptic meningitis occuring in 1978 in Khabarovsk was performed. The leading etiological agent was found to be ECHO-4 virus. Some of the cases were associated with ECHO-20 and Coxsackie B1 viruses. Investigation of the herd immunity to these viruses in the urban population showed that before the outbreak the immune portion to ECHO-4 and ECHO-20 viruses was low, particularly in children and youngsters. This might be due to the fact that active circulation of these viruses and outbreaks of diseases associated with them had occurred 13--15 years before. The immune portion to enteroviruses in different towns of the Far East was shown to be uneven. The results of investigations of the epidemic outbreak and herd immunity permit to consider it to be a typical manifestation of the cyclic circulation of enteroviruses in the territory and in time.
Asunto(s)
Infecciones por Enterovirus/epidemiología , Meningitis Viral/epidemiología , Adolescente , Adulto , Niño , Preescolar , Infecciones por Coxsackievirus/epidemiología , Infecciones por Echovirus/epidemiología , Humanos , Lactante , Poliomielitis/epidemiología , SiberiaRESUMEN
The etiology of an influenza outbreak which had occurred in Khabarovsk since 14 November, 1977 was elucidated. The largest number of cases was recorded among children and adolescents (under 22 years of age). Virological studies during the epidemic yielded 90 strains of influenza virus which were found to be antigenically quite close to A1 virus (HINI) which had circulated in this country in 1947-1956. Influenza viruses could be isolated from subjects under 22. Serological tests (H1, CFT) with paired sera from influenza patients and determinations of IgM showed A1 virus (HINI) to circulate more intensively among subjects under 22 years. A correlation between the presence of humoral immunity in subject over 22 and low incidence of influenza in these population are groups was observed.