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In this study, we evaluated the toxicological and antiproliferative effects of B. glabra Choisy bract extract (BGCE) in its free and loaded into liposomes forms administered to C. elegans mutants with let-60 gain-of-function (gf). Our results demonstrated that the concentration up to 75 µg CAE/mL of BGCE was safe for the worms. Notably, we developed BGCE-loaded liposomes to extend the pharmacological window up to 100 µg CAE/mL without toxicity. In addition, the extract and liposomes reduced the number and area of the multivulva formed in let-60 gf mutants. There was also an increase in the apoptotic signaling in the germline cells and increased longevity mediated through DAF-16 nuclear translocation with GST-4 activation in the treated animals. Our findings demonstrated that the BGCE-loaded liposomes possess antitumoral effects due to the activation of the apoptotic signaling and DAF-16 nuclear translocation.

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Resumo Objetivo Avaliar a qualidade do sono de profissionais dos serviços de emergência e sua associação com o nível de fadiga e qualidade de vida. Métodos Estudo descritivo, transversal e correlacional, realizado nas unidades do Serviço de Atendimento Móvel de Urgência (SAMU) e na Unidade de Pronto Atendimento (UPA), no ano de 2021, com 108 participantes. Para avaliação da qualidade do sono, foi utilizado o Índice de Qualidade do Sono de Pittsburgh versão Brasileira (PSQI-BR); para avaliação da Fadiga, foi utilizada a Escala de Fadiga de Chalder, em conjunto com a Escala de Necessidade de Descanso (ENEDE); e para avaliação da qualidade de vida, foi utilizado o World Health Organization Quality of Life Brief Version (WHOQOL-bref), sendo que os instrumentos utilizados foram adaptados para a língua portuguesa em estudos anteriores. Foram aplicados testes de associação para a análise estatística, tendo sido utilizados o Teste Qui-Quadrado de Pearson, o Teste U Mann-Whitney ou Kruskal Wallis e a correlação de Spearman. Valores de p <0,05 foram considerados como significativos. Resultados Foi identificado que 72,2% dos participantes apresentaram má qualidade do sono e 75,9% estavam fadigados. Foi observada associação significativa entre a qualidade do sono e a fadiga, a necessidade de descanso e a qualidade de vida. Conclusão Foi identificado que os profissionais de saúde que trabalham em serviço de urgência e emergência apresentam má qualidade do sono e de vida e níveis elevados de fadiga e necessidade de descanso, o que pode impactar diretamente suas atividades pessoais e profissionais.

Resumen Objetivo Evaluar la calidad del sueño de profesionales de los servicios de emergencia y su relación con el nivel de fatiga y calidad de vida. Métodos Estudio descriptivo, transversal y correlacional, realizado en las unidades del Servicio de Atención Móbil de Urgencia (SAMU) y en la Unidad de Pronta Atención (UPA), en el año 2021, con 108 participantes. Para evaluar la calidad del sueño, se utilizó el Índice de Calidad del Sueño de Pittsburgh, versión brasileña (PSQI-BR). Para evaluar la fatiga, se utilizó la Escala de Fatiga de Chalder, junto con la Escala de Necesidad de Descanso (ENEDE). Para evaluar la calidad de vida, se utilizó el World Health Organization Quality of Life Brief Version (WHOQOL-bref). Los instrumentos utilizados fueron adaptados al idioma portugués en estudios anteriores. Se aplicaron pruebas de asociación para el análisis estadístico, para lo cual se utilizó la Prueba χ2 de Pearson, la Prueba U de Mann-Whitney o la prueba de Kruskal-Wallis y la correlación de Spearman. Se consideraron valores de p<0,05 como significativos. Resultados Se identificó que el 72,2 % de los participantes presentó una mala calidad de sueño y el 75,9 % tenía fatiga. Se observó una asociación significativa entre la calidad del sueño y la fatiga, la necesidad de descanso y la calidad de vida. Conclusión Se identificó que los profesionales de la salud que trabajan en servicios de urgencia y emergencia presentaron mala calidad de sueño y de vida y niveles elevados de fatiga y necesidad de descanso, lo que puede impactar directamente en sus actividades personales y profesionales.

Abstract Objective To assess emergency service professionals' sleep quality and its association with the level of fatigue and quality of life. Methods A descriptive, cross-sectional and correlational study, carried out in the units of the Mobile Emergency Care Service (SAMU) and in the Emergency Care Unit (ECU), in 2021, with 108 participants. To assess sleep quality, the Pittsburgh Sleep Quality Index, Brazilian version (PSQI-BR), was used; to assess fatigue, the Chalder Fatigue Scale was used, together with the Need for Recovery Scale (NFR); and to assess quality of life, the World Health Organization Quality of Life Brief Version (WHOQOL-bref) was used, and the instruments used were adapted to Portuguese in previous studies. Association tests were applied for statistical analysis, using Pearson's chi-square test, Mann-Whitney U test or Kruskal Wallis and Spearman's correlation. P-values <0.05 were considered significant. Results It was identified that 72.2% of participants had poor sleep quality and 75.9% were fatigued. A significant association was observed between sleep quality and fatigue, the need for recovery and quality of life. Conclusion It was identified that health professionals working in emergency services have poor sleep quality and life, and high levels of fatigue and need for recovery, which can directly impact their personal and professional activities.

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Abstract Objective: to analyze the factors related to sleep disorders reported by Nursing professionals during the COVID-19 pandemic. Method: this is a cross-sectional and analytical study conducted with Nursing professionals from all Brazilian regions. Sociodemographic data, working conditions and questions about sleep disorders were collected. The Poisson regression model with repeated measures was used to estimate the Relative Risk. Results: 572 answers were analyzed, which revealed that non-ideal sleep duration, poor sleep quality and dreams about the work environment were predominant during the pandemic, with 75.2%, 67.1% and 66.8% respectively; as well as complaints of difficulty sleeping, daytime sleepiness and non-restorative sleep during the pandemic were reported by 523 (91.4%), 440 (76.9%) and 419 (73.2%) of the Nursing professionals, respectively. The relative risk of having such sleep disorders during the pandemic was significant for all variables and categories studied. Conclusion: non-ideal sleep duration, poor sleep quality, dreams about the work environment, complaints regarding difficulty sleeping, daytime sleepiness and non-restorative sleep were the predominant sleep disorders among Nursing professionals during the pandemic. Such findings point to possible consequences on health, as well as on the quality of the work performed.

Resumo Objetivo: analisar os fatores relacionados às alterações no sono relatadas pelos profissionais de enfermagem durante a pandemia de COVID-19. Método: trata-se de um estudo transversal e analítico, realizado com profissionais de enfermagem de todas as regiões do Brasil. Foram coletados dados de caracterização sociodemográfica, condições de trabalho e questões sobre alterações de sono. Para estimar o Risco Relativo foi utilizado o modelo de regressão de Poisson com medidas repetidas. Resultados: foram analisadas 572 respostas, as quais revelaram que a duração não ideal do sono, a má qualidade do sono e os sonhos com o ambiente de trabalho foram predominantes durante a pandemia, com 75,2%, 67,1% e 66,8% respectivamente, assim como as queixas de dificuldade ao dormir, sonolência diurna e sono não restaurador durante a pandemia foram relatadas por 523 (91,4%), 440 (76,9%) e 419 (73,2%) dos profissionais de enfermagem, respectivamente. O risco relativo de apresentar tais alterações de sono, durante a pandemia foi significativo para todas as variáveis e as categorias estudadas. Conclusão: duração não ideal do sono, má qualidade do sono, sonhos com o ambiente de trabalho, queixas de dificuldade ao dormir, sonolência diurna e sono não restaurador foram as alterações do sono predominantes entre os profissionais de enfermagem durante a pandemia. Estes achados apontam para possíveis consequências na saúde, bem como na qualidade do trabalho realizado.

Resumen Objetivo: analizar los factores relacionados con los trastornos del sueño que informaron los profesionales de enfermería durante la pandemia de COVID-19. Método: se trata de un estudio transversal y analítico realizado con profesionales de enfermería de todas las regiones de Brasil. Se recolectaron datos sobre caracterización sociodemográfica, condiciones de trabajo y preguntas sobre trastornos del sueño. Para estimar el Riesgo Relativo se utilizó el modelo de regresión de Poisson con medidas repetidas. Resultados: se analizaron 572 respuestas, que revelaron que durante la pandemia predominaron la duración del sueño no ideal, la mala calidad del sueño y los sueños sobre el ambiente laboral, con 75,2%, 67,1% y 66,8% respectivamente, además 523 (91,4%), 440 (76,9%) y 419 (73,2%) profesionales de enfermería manifestaron quejas de dificultad para conciliar el sueño, somnolencia diurna y sueño no reparador durante la pandemia, respectivamente. El riesgo relativo de padecer trastornos del sueño durante la pandemia fue significativo para todas las variables y categorías estudiadas. Conclusión: la duración del sueño no ideal, la mala calidad del sueño, los sueños sobre el ambiente laboral, las quejas de dificultad para conciliar el sueño, la somnolencia diurna y el sueño no reparador fueron los trastornos del sueño predominantes en los profesionales de enfermería durante la pandemia. Estos hallazgos indican posibles consecuencias para la salud, así como para la calidad del trabajo realizado.

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Alzheimer's disease (AD) is the most common form of dementia in older people, and available treatments are palliative and produce undesirable side effects. The 4-phenyltellanyl-7-chloroquinoline (TQ) is an organochalcogen compound studied due to its pharmacological properties, particularly its antioxidant potential. However, TQ possesses some drawbacks such as low aqueous solubility and high toxicity, thus warranting the search for tools that improve the safety and effectiveness of new compounds. Here, we developed and investigated the biological effects of TQ-loaded polymeric nanocapsules (NCTQ) in an AD model in transgenic Caenorhabditis elegans expressing human Aß1-42 in their body-wall muscles and Swiss mice injected with Aß25-35. The NCTQ displayed good physicochemical properties, including nanometer size and maximum encapsulation capacity. The treatment showed low toxicity, reduced Aß peptide-induced paralysis, and activated an endoplasmic reticulum chaperone in the C. elegans model. The Aß injection in mice caused memory impairment, which NCTQ mitigated by improving working, long-term, and aversive memory. Additionally, no changes in biochemical markers were evidenced in mice, demonstrating that there was no hepatotoxicity in the tested doses. Altogether, these findings provide insights into the neuroprotective effects of TQ and indicate that NCTQ is a promising candidate for AD treatment.

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OBJECTIVE: to analyze the factors related to sleep disorders reported by Nursing professionals during the COVID-19 pandemic. METHOD: this is a cross-sectional and analytical study conducted with Nursing professionals from all Brazilian regions. Sociodemographic data, working conditions and questions about sleep disorders were collected. The Poisson regression model with repeated measures was used to estimate the Relative Risk. RESULTS: 572 answers were analyzed, which revealed that non-ideal sleep duration, poor sleep quality and dreams about the work environment were predominant during the pandemic, with 75.2%, 67.1% and 66.8% respectively; as well as complaints of difficulty sleeping, daytime sleepiness and non-restorative sleep during the pandemic were reported by 523 (91.4%), 440 (76.9%) and 419 (73.2%) of the Nursing professionals, respectively. The relative risk of having such sleep disorders during the pandemic was significant for all variables and categories studied. CONCLUSION: non-ideal sleep duration, poor sleep quality, dreams about the work environment, complaints regarding difficulty sleeping, daytime sleepiness and non-restorative sleep were the predominant sleep disorders among Nursing professionals during the pandemic. Such findings point to possible consequences on health, as well as on the quality of the work performed.

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OBJECTIVES: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the presence of aggregated amyloid-ß (Aß) peptides. Several natural compounds have been proposed against this disease and grape products are among these. However, little is known about grape juice potential. Transgenic Caenorhabditis elegans (C. elegans) strains that express human Aß have been used as an in vivo model for AD. METHODS: In this study, we have exposed CL2006 worms to nine different juices obtained from different cultivars. RESULTS: Cora, Bordo, Isabel, Isabel Precoce, BRS-Magna, BRS-Rubea and BRS-Violeta juices improved the behavioral phenotype (paralysis) that is caused by Aß aggregation in the transgenic animals at the concentrations tested and no toxic effects were found. Some juices were also able to increase the worm's lifespan. We could not attribute lifespan increase and paralysis reduction with any specific compound found in the phytochemical analysis. DISCUSSION: Our data indicate that the rich constitution of the juices is responsible for attenuating the phenotype caused by Aß aggregation in C. elegans.

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BACKGROUND: The COVID-19 pandemic may trigger sleep disorders and burnout in nursing professionals. PURPOSE: This study was designed to describe the occurrence of sleep disorders and burnout in a nursing team during the COVID-19 pandemic and to identify the associated factors. METHODS: A cross-sectional approach was used. The questionnaire was administered via the Internet. All of the participants were nursing professionals who had provided care during the COVID-19 pandemic, and data were collected between June and August 2020. Sociodemographic and work characterization instruments, the Jenkins Sleep Scale, and the Maslach Burnout Inventory were used. RESULTS: Five hundred seventy-two nursing professionals (nurses, nursing technicians, and nursing assistants) responded. Slightly over one quarter (26.4%) presented a sleep disorder, and 17.3% presented burnout. Professional category was a factor found to be associated with having a sleep disorder. Moreover, a lower prevalence both of disorders and of starting to use sleep medication was found among nurses than nursing assistants. Moreover, an association was found between having a high level of emotional exhaustion burnout and being a nursing technician, having a higher number of patients needing care, and starting to use sleep medication. The level of burnout related to depersonalization was significantly higher for nursing assistants, those with a weekly workload of 50 hours or more, and those starting to use sleep medication. Furthermore, burnout related to personal accomplishment was significantly higher in those starting to use sleep medication. Among the participants with sleep disorders, according to Jenkins Sleep Scale results, all of the participants presented a high or moderate level of emotional exhaustion and a high level of burnout related to personal accomplishment. CONCLUSIONS/IMPLICATIONS FOR PRACTICE: The findings indicate that the incidence of sleep disorders and burnout were high among nursing professionals during the COVID-19 pandemic and mainly related with starting to use sleep medication. The results demonstrate the importance of detecting and assessing the frequency of sleep disorders and professional exhaustion. Interventions that aim to improve sleep quality and working conditions for these professionals should be developed.

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OBJECTIVE: to report the professional experience of a nurse manager facing the challenges of restructuring a hospital service in the face of the COVID-19 pandemic. METHOD: this is an experience report, based on the perspective of system resilience in a public hospital. RESULTS: the challenges faced were: internal service flow reorganization to assist suspected cases of COVID-19; institution of structural changes and adaptations, from entry into the emergency room to the wards and intensive care unit; equipment and supply acquisition for patient care with a focus on their quality and functionality; staff training, with the restructuring of work processes; staff sizing, considering the time of exposure to the virus; staff's professional qualification, absenteeism, stress, physical and psychological illness, with a view to safe and quality care; nursing staff leadership to deal with conflicts generated by professionals' stress and illness. CONCLUSION: healthcare service resilience is critical for hospital restructuring in the COVID-19 pandemic; however, patient care and healthcare professionals' physical and mental health must be considered.

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In a previous in vitro study, dihydropyrimidinone-derived selenoesteres demonstrated antioxidant properties, metal chelators and inhibitory acetylcholinesterase (AChE) activity, making these compounds promising candidates for Alzheimer's Disease (AD) treatment. However, these effects have yet to be demonstrated in an in vivo animal model; therefore, this study aimed to evaluate the safety and efficacy of eight selenoester compounds in a Caenorhabditis elegans model using transgenic strains for amyloid-beta peptide (Aß) aggregation. The L1 stage worms were acutely exposed (30 min) to the compounds at concentrations ranging from 5 to 200 µM and after 48 h the maintenance temperature was increased to 25 ° C for Aß expression and aggregation. After 48 h, several parameters related to phenotypic manifestations of Aß toxicity and mechanistic elucidation were analyzed. At the concentrations tested no significant toxicity of the compounds was found. The selenoester compound FA90 significantly reduced the rate of paralyzed worms and increased the number of swimming movements compared to the untreated worms. In addition, FA90 and FA130 improved egg-laying induced by levamisole and positively modulated HSP-6 and HSP-4 expression, thereby increasing reticular and mitochondrial protein folding response in C. elegans, which could attenuate Aß aggregation in early exposure. Therefore, our initial screening using an alternative model demonstrated that FA90, among the eight selenoesters evaluated, was the most promising compound for AD evaluation screening in more complex animals.

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BACKGROUND: We estimate work loss and economic costs due to mental and substance use disorders in the economically active population of the São Paulo Metropolitan Area, Brazil. METHODS: The São Paulo Megacity Mental Health Survey assessed a population-based sample of 3,007 economically active residents using the Composite International Diagnostic Interview 3.0 and the World Health Organization Disability Assessment Schedule 2 to investigate, respectively, 12-month psychiatric disorders, work performance, and economic costs. RESULTS: Absenteeism over the past 12 months was reported by 12.6%, and presenteeism by 14.7% (qualitative loss) and 13.1% (quantitative loss). Having any mental disorder was associated with 17.6 days of absenteeism and 37.7 days of reduced-qualitative and/or quantitative functioning. Fourteen mental disorders were significantly associated with work loss, with odds ratios ranging from 2.3 for adult separation anxiety to 40.4 for oppositional defiant disorder. At a population-level, oppositional defiant disorder, panic disorder, attention deficit disorder, and dysthymia contributed to the largest costs. The total annual economic costs were USD $83.2 billion/year, representing 6.1% of Brazil's Gross Domestic Product in 2007. LIMITATIONS: Diagnosis of mental disorders was based on self-reported symptoms. Work loss assessment was restricted to 30 days before the interview and may not fully represents the annual real experience and symptoms of the respondents which would lead to an overestimation of the burden. CONCLUSIONS: Mental disorders impose a great negative impact on work performance and functioning, with a consequent high economic burden, pointing to the need of implementing cost-effective interventions to prevent work loss.

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Resumo Atualmente, muitos pacientes procuram tratamento ortodôntico por motivos funcionais, não apenas estéticos. A perda de um elemento dental leva a um desequilíbrio tanto oclusal quanto periodontal, caracterizados por diversos malefícios aos dentes e estruturas de suporte, tais como perdas ósseas, contatos prematuros e falta de espaço para confecção de próteses. Por isso, a verticalização do molar é de suprema importância pois leva à normalização da condição funcional, periodontal e oclusal. O objetivo desse trabalho é relatar um caso clínico, em que a verticalização foi realizada com o objetivo de estabelecer a função e estética. Para isso, um novo bráquete com a presença de dois slots foi utilizado. Com a utilização desse dispositivo, conseguiu-se minimizar os efeitos indesejados, reduzir o número de acessórios de ancoragem, maior controle de movimento e simplificar a mecânica ortodôntica de verticalização. (AU)

Abstract Patients seek orthodontic treatment not only for aesthetics, but also for functional reasons. The loss of a posterior tooth leads to occlusal and periodontal imbalance, characterized by several risks to teeth and supporting structures such as bone loss, premature occlusal contact, and lack of space for prosthetic rehabilitation. Therefore, the uprighting of a molar is of paramount importance as it leads to the normalization of the functional, periodontal, and occlusal status. The objective of this work is to report a clinical case of molar uprighting with the objective of establishing proper function and occlusion using a new bracket with two separate slots. The use of this bracket minimizes the undesirable effects of regular braces, reduces the number of anchoring accessories, optimizes control of tooth movement, and simplifies orthodontic mechanics.(AU)

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ABSTRACT Objective: to report the professional experience of a nurse manager facing the challenges of restructuring a hospital service in the face of the COVID-19 pandemic. Method: this is an experience report, based on the perspective of system resilience in a public hospital. Results: the challenges faced were: internal service flow reorganization to assist suspected cases of COVID-19; institution of structural changes and adaptations, from entry into the emergency room to the wards and intensive care unit; equipment and supply acquisition for patient care with a focus on their quality and functionality; staff training, with the restructuring of work processes; staff sizing, considering the time of exposure to the virus; staff's professional qualification, absenteeism, stress, physical and psychological illness, with a view to safe and quality care; nursing staff leadership to deal with conflicts generated by professionals' stress and illness. Conclusion: healthcare service resilience is critical for hospital restructuring in the COVID-19 pandemic; however, patient care and healthcare professionals' physical and mental health must be considered.

RESUMEN Objetivo: relatar la experiencia profesional de una enfermera gestora frente a los desafíos de la reestructuración de un servicio hospitalario frente a la pandemia de la COVID-19. Método: relato de experiencia, basado en la perspectiva de resiliencia del sistema en un hospital público. Resultados: los desafíos enfrentados fueron: reorganización del flujo interno de atención para la atención de casos sospechosos de COVID-19; institución de cambios y adaptaciones estructurales, desde el ingreso al departamento de urgencias y emergencias hasta las salas y unidad de cuidados intensivos; adquisición de equipos e insumos para la atención de pacientes con enfoque en su calidad y funcionalidad; formación de equipos con la reestructuración de los procesos de trabajo; dimensionamiento del personal, considerando el tiempo de exposición al virus, cualificación profesional, ausentismo, estrés, enfermedad física y psíquica del equipo, con miras a un cuidado seguro y de calidad y liderazgo del equipo de enfermería para el enfrentamiento de los conflictos generados por el estrés y la enfermedad de los profesionales. Conclusión: la resiliencia del servicio de salud es fundamental para la reestructuración hospitalaria en la pandemia del COVID-19, sin embargo, se debe considerar la atención al paciente y la salud física y mental de los profesionales de la salud.

RESUMO Objetivo: relatar a experiência profissional de um enfermeiro gestor frente aos desafios da reestruturação de um serviço hospitalar diante da pandemia da COVID-19. Método: relato de experiência, baseado na perspectiva da resiliência do sistema em um hospital público. Resultados: os desafios enfrentados foram: reorganização do fluxo de serviço interno para atender os casos suspeitos de COVID-19; instituição de mudanças e adaptações estruturais, desde a entrada na urgência e emergência, até nas enfermarias e unidade de terapia intensiva; aquisição de equipamentos e insumos para o atendimento dos pacientes com foco na qualidade e funcionalidade destes; treinamento das equipes, com a reestruturação dos processos de trabalho; dimensionamento de pessoal, considerando o tempo de exposição ao vírus; qualificação profissional, absenteísmo, estresse, adoecimento físico e psicológico da equipe, com vistas à uma assistência segura e de qualidade; liderança da equipe de Enfermagem para lidar com os conflitos gerados pelo estresse e adoecimento dos profissionais. Conclusão: a resiliência do serviço de saúde é fundamental para a reestruturação hospitalar na pandemia da COVID-19, no entanto, devem-se considerar o cuidado dos pacientes e a saúde física e mental dos profissionais de saúde.

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ABSTRACT Objective: to assess the quality of life of nurse practitioners during the COVID-19 pandemic and analyze related factors. Methods: cross-sectional and analytical study carried out with nurse practitioners. A questionnaire on sociodemographic characterization, work activities and changes perceived with the pandemic and WHOQOL-bref were used. To compare the groups of interest, analysis of covariance was used. Results: 572 professionals participated, who had a mean total quality of life score of 56.79 (SD=13.56). In the relationship of variables with WHOQOL-bref, having two or more jobs and being a nurse were associated with better quality of life, but being a woman and working more than 50 hours a week was associated with a worse perception of the construct. Conclusions: the factors analyzed indicate a lower perception of quality of life associated with the social domain, requiring interventions that reduce the damage to professionals' health and contribute to quality of care provided.

RESUMEN Objetivo: evaluar la calidad de vida de los profesionales de enfermería durante la pandemia del COVID-19 y analizar los factores relacionados. Métodos: estudio transversal y analítico realizado con profesionales de enfermería. Se utilizó un cuestionario sobre caracterización sociodemográfica, actividades laborales y cambios percibidos con la pandemia y WHOQOL-bref. Para comparar los grupos de interés se utilizó el análisis de covarianza. Resultados: participaron 572 profesionales, quienes tuvieron una puntuación media de calidad de vida total de 56,79 (DE=13,56). En la relación de las variables con el WHOQOL-bref, tener dos o más trabajos y ser enfermera se asociaron a una mejor calidad de vida, pero ser mujer y trabajar más de 50 horas semanales se asoció a una peor percepción del constructo. Conclusiones: los factores analizados indican una menor percepción de la calidad de vida asociada al dominio social, requiriendo intervenciones que reduzcan el daño a la salud de los profesionales y contribuyan a la calidad de la atención brindada.

RESUMO Objetivo: avaliar a qualidade de vida dos profissionais de enfermagem durante a pandemia de COVID-19 e analisar os fatores relacionados. Métodos: estudo transversal e analítico, realizado com profissionais de enfermagem. Utilizaram-se questionário de caracterização sociodemográfica, atividades do trabalho e mudanças percebidas com a pandemia e WHOQOL-bref. Para comparar os grupos de interesse, adotou-se a análise de covariância. Resultados: participaram 572 profissionais, os quais apresentaram escore total médio de qualidade de vida de 56,79 (DP=13,56). Na relação das variáveis com o WHOQOL-bref, ter dois ou mais vínculos de trabalho e ser enfermeiro estavam associados à melhor qualidade de vida, mas ser mulher e cumprir carga horária superior a 50 horas semanais associou-se à pior percepção do construto. Conclusões: os fatores analisados indicam menor percepção de qualidade de vida associados ao domínio social, sendo necessárias intervenções que reduzam os prejuízos à saúde dos profissionais e contribuam com a qualidade da assistência oferecida.

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OBJECTIVE: To translate, adapt and validate the contents of the Adverse Childhood Experiences International Questionnaire to a Portuguese version, to be used in Brazil, named Questionário Internacional de Experiências Adversas na Infância. METHODS: This is a methodological study of cross-cultural adaptation of evaluation instruments presenting the results of semantic equivalence between the original instrument and the adapted version. The semantic equivalence of the instrument involved the following steps: 1) two translations and a synthesis of the translations; 2) two retranslations; 3) validation of contents by eight health workers; 4) synthesis of the retranslations; 5) pre-tests to assess acceptability, understanding and emotional impact of the questions; and, finally, 6) writing of the final version of the instrument. RESULTS: the adapted version proved to be easy to apply and to understand and achieved good semantic equivalence when compared to the original version. The psychometric properties of the instrument still need to be evaluated. Limitations and recommendations for improving the instrument and its use are presented. CONCLUSION: The process of cross-cultural adaptation of the Adverse Childhood Experiences International Questionnaire resulted in an adapted version to Brazilian Portuguese.

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OBJECTIVE: to assess the quality of life of nurse practitioners during the COVID-19 pandemic and analyze related factors. METHODS: cross-sectional and analytical study carried out with nurse practitioners. A questionnaire on sociodemographic characterization, work activities and changes perceived with the pandemic and WHOQOL-bref were used. To compare the groups of interest, analysis of covariance was used. RESULTS: 572 professionals participated, who had a mean total quality of life score of 56.79 (SD=13.56). In the relationship of variables with WHOQOL-bref, having two or more jobs and being a nurse were associated with better quality of life, but being a woman and working more than 50 hours a week was associated with a worse perception of the construct. CONCLUSIONS: the factors analyzed indicate a lower perception of quality of life associated with the social domain, requiring interventions that reduce the damage to professionals' health and contribute to quality of care provided.

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OBJECTIVE: to assess sleep quality in menopausal women and its association with symptoms related to this period. METHOD: this is a cross-sectional, analytical and correlational study. Sleep was assessed using the Pittsburgh Sleep Quality Index; and climacteric symptoms, according to the Menopause Rating Scale. To compare the total score and each Menopause Rating Scale domain with the PSQI classification, the Mann-Whitney U non-parametric test was used. P<0.05 was considered significant. RESULTS: 261 women (67.8%) were classified as bad sleepers. There was a positive and significant correlation between the sleep scale scores and the total menopause score and its domains. Women categorized as poor sleepers had worse scores on the menopause symptom scale. CONCLUSION: women with worse sleep quality revealed greater severity of symptoms related to menopause.

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RESUMO O objetivo deste estudo foi identificar e descrever os instrumentos mais frequentemente utilizados nas pesquisas epidemiológicas para a avaliação das Experiências Adversas na Infância, nos últimos dez anos. Trata-se de uma revisão da literatura, cujos critérios de inclusão foram artigos disponíveis na íntegra, nos idiomas inglês, espanhol e português, publicados e indexados nas bases de dados Medline e Lilacs, que citassem no resumo os instrumentos de avaliação utilizados nos estudos. Foram analisados 6 dos 38 instrumentos identificados nos 253 artigos selecionados para análise. Os instrumentos mais citados foram: 1) Childhood Trauma Questionnaire, 2) Childhood Experience of Care and Abuse, 3) Adverse Childhood Experiences Questionnaire, 4) Child Abuse and Trauma Scale, 5) Early Trauma Inventory Self Report e 6) Adverse Childhood Experiences International Questionnaire. Os instrumentos descritos diferiram quanto às propriedades psicométricas, à idade para aplicação e à quantidade de Experiências Adversas na Infância avaliadas. Predominaram estudos publicados em periódicos internacionais na língua inglesa. Três instrumentos apresentam versão em português vigente no Brasil, sendo que um deles considera somente a avaliação de aspectos específicos de Experiências Adversas na Infância, enquanto que os outros dois avaliam, também, outras experiências traumáticas.

ABSTRACT This study aimed to identify and describe the most frequently used instruments in epidemiological research to assess Adverse Childhood Experiences, in the past ten years. This is an integrative literature review, whose inclusion criteria were: full text articles in English, Spanish and Portuguese, published and indexed in the Medline and Lilacs databases, which cited in the summary the assessment instruments used in the studies. Six of the 38 instruments identified in the 253 articles selected for analysis were analyzed. The most cited instruments were: 1) Childhood Trauma Questionnaire, 2) Childhood Experience of Care and Abuse, 3) Adverse Childhood Experiences Questionnaire, 4) Child Abuse and Trauma Scale, 5) Early Trauma Inventory Self Report and 6) Adverse Childhood Experiences International Questionnaire. The instruments described differed in terms of psychometric properties, age for application and number of Adverse Childhood Experiences assessed. Studies published in international journals in the English language predominated. Three instruments have a Brazilian Portuguese version, one of which only considers the assessment of specific aspects of Adverse Childhood Experiences, while the other two also evaluates other traumatic experiences.

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INTRODUÇÃO: A paroxismia de tronco encefálico, descrita em pacientes com esclerose múltipla (EM), caracteriza-se por episódios rápidos de vertigem e nistagmos evocados por movimentos cefálicos. A neuromodulação tem apresentado sucesso terapêutico em várias disfunções da EM, mas ainda não foi utilizada na paroxismia. OBJETIVO: Avaliar o efeito aditivo da neuromodulação por estimulação elétrica neural transcutânea (TENS) na musculatura periocular em paciente com EM e paroxismia de tronco encefálico não responsiva à reabilitação clássica associada à medicação. MATERIAL E MÉTODOS: Avaliação do nistagmo com videonistagmógrafo, da sensibilidade cutânea facial com estesiômetro, do blefaroclônus por gravação em vídeo e da sensação dolorosa de forma subjetiva (descrição pessoal da paciente); execução de 10 sessões consecutivas semanais de exercícios oculares associados à TENS na musculatura do oblíquo inferior e reto lateral direitos. RESULTADO: Melhora da algia, do blefaroclônus, da vertigem e do nistagmo ocular direito. CONCLUSÃO: A neuromodulação com TENS parece ser uma terapia complementar válida para pacientes com EM e paroxismia de tronco não responsivos aos demais tratamentos clínicos, porém mais estudos são necessários para confirmar esse achado.

INTRODUCTION: Brainstem paroxysmia has been described in patients with multiple sclerosis, characterized by rapid episodes of nystagmus and vertigo evoked by cephalic movements. Neuromodulation has shown therapeutic success for several dysfunctions of multiple sclerosis, but it has not yet been used in paroxysmia. OBJECTIVE: To assess the additive effect of neuromodulation by transcutaneous electrical neural stimulation (TENS) on the periocular musculature in a patient with multiple sclerosis and brain stem paroxysmia that is not responsive to classical rehabilitation associated with medication. MATERIAL AND METHODS: Nystagmus evaluation with video nystagmography, facial skin sensitivity analysis with esthesiometer, video recording of blepharoclonus, and pain sensation subjectively quantification (by a personal description of the patient); execution of 10 eyes consecutive exercises sessions associated with TENS in the right lower oblique and lateral rectus muscles. RESULT: Improvement in pain, blepharoclonus, and right eye nystagmus. CONCLUSION: Neuromodulation with TENS seems to be a valid complementary therapy for patients with brainstem paroxysmia unresponsive to other clinical treatments, but more studies are needed to confirm this finding.

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