RESUMEN

The results in this paper indicate that mitochondrial permeability transition is activated by dysfunction of the respiratory chain caused by anaerobiosis, exhaustion of the oxidative substrate, and antimycin A, in the presence of 100 microM Ca2+. Membrane damage coincides with the collapse of the electric gradient. The opening of the non-selective pore is prevented by cyclosporin A.

Asunto(s)

Membranas Intracelulares/metabolismo , Mitocondrias/metabolismo , Mitocondrias/ultraestructura , Adenosina Trifosfato/metabolismo , Adenosina Trifosfato/farmacología , Anaerobiosis , Animales , Antimicina A/farmacología , Calcio/metabolismo , Calcio/farmacocinética , Transporte de Electrón , Potenciales de la Membrana/fisiología , Mitocondrias/fisiología , Oxígeno/metabolismo , Consumo de Oxígeno/fisiología , Permeabilidad , Ratas , Vacunas Sintéticas/inmunología