RESUMEN
BACKGROUND: To study the relationship between lipid profile and body mass index (BMI) in children after a 5-year follow-up. METHOD: A total of 281 children were evaluated at the ages of 6 and 11 years. Total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and apoproteins A1 (Apo A) and B100 (Apo B) were measured. Low-density lipoprotein cholesterol (LDL-C) was determined and the Apo B/Apo A, TC/HDL-C, LDL-C/HDL-C indexes, and the atherogenic index were calculated. BMI was also calculated (BMI 5 kg/m2). Evolution parameters were calculated (EVO 5 value 11 years - value 6 years). Associations between BMI and lipid profile were studied. RESULTS: The prevalence of obesity (according to the criteria of the International Obesity Task Force) was 4.98 % (6 years) and 16,72 % (11 years). In children who were in the fourth BMI quartile at the age of 11 years, LDL-C/HDL-C and TC/HDL-C levels were significantly higher and than those in children in the first quartile but HDL-C and Apo A levels were lower. A significant positive correlation was found between the evolution of BMI and the four indexes studied and TG, but this correlation was negative for HDL-C and Apo A. The evolution of the indexes was positive in 11-year-old obese children and negative in nonobese children. CONCLUSIONS: Lipid profile was worse in 11-year-old children in the fourth BMI quartile than in the remaining children. Obese children had higher values of the indexes studied, supporting the importance of obesity as a cardiovascular risk factor.
Asunto(s)
Apoproteínas/sangre , Índice de Masa Corporal , Colesterol/sangre , Lipoproteínas/sangre , Triglicéridos/sangre , Niño , Femenino , Estudios de Seguimiento , Humanos , Masculino , Factores de TiempoRESUMEN
AIM: Evaluate the lipid profiles in children after two years of follow-up. METHODS: Longitudinal cohort study. A two years follow-up of a group of children since they were 6 years old. Blood analysis were carried in every children measuring total cholesterol, triglycerides, cLDL, cHDL, apoproteins A and B. It also included TD/cHDL, cLDL/cHDL, Apo B/A ratios and atherogenic index. RESULTS: 200 mg/dl, cLDL > 135 mg/dl and Apo B > 100 mg/dl in the follow-up was of 9.51, 5.18 and 8 for those children who had in the initial study these same values. The values of lipid profile and of the index studied improved in the two years of follow-up. This improvement has an statistical signification only in men. CONCLUSIONS: There is a significant correlation between the values of the lipid profile and the index measured in those children who were six years old in the beginning of the two years follow-up.
Asunto(s)
Apolipoproteínas/sangre , Colesterol/sangre , Triglicéridos/sangre , Niño , Estudios de Cohortes , Femenino , Estudios de Seguimiento , Humanos , Masculino , España , Factores de TiempoRESUMEN
OBJECTIVE: The purpose of this study was to analyze the lipid profiles in children six years of age according to sex and to compare this with other Spanish studies. PATIENTS AND METHODS: A transverse epidemiological study was performed. All six year old children in our area were studied. The following tests were performed in all children: total cholesterol (TC), triglycerides, LDL-C, HDL-C, apoproteins A and B after fasting for ten hours. In addition, TC/HDL-C, LDL-C/HDL-C, and Apo B/A ratios and atherogenic index (ATI) were calculated. RESULTS: A population of 673 subjects (352 males and 321 females) were studied. The value of TC, triglycerides, LDL-C, Apo B, LDL-C/HDL-C and TC/HDL-C were significantly greater in females compared to males. Males had higher levels of HDL-C and ApoA. The values were similar to those obtain in Madrid in 1992, except that the values of HL-C were significantly higher in both sexes. CONCLUSIONS: In six year old children, the lipid profile in girls is worse than in boys. The data from our study do not show that the lipidic risk is getting worse during the past years in Spanish children.