RESUMEN
Selenium concentrations in the full blood and erythrocyte and plasma GSH-Px activity were determined in patients with cancer of the stomach, colon and rectum. The results were compared with those in the group of healthy subjects. Blood samples were collected into heparinized tubes prior to surgery. Selenium concentrations in the full blood and plasma were lower (75.5 ng/mL and 56.2 ng/ml, respectively) in patients with the cancer of the stomach than healthy subjects (99.5 ng/ml and 78.5 ng/mL, respectively; p < 0.0001). Concentration of this element in both full blood and plasma was also lower in patients with cancer of the colon and rectum (77.7 ng/mL and 61.0 ng/ml, respectively; p < 0.0001). Erythrocyte and plasma GSH-Px activity was also significantly lower (p < 0.001) in patients with cancer of the stomach than in healthy subjects, and amounted to 13.6 U/g Hb and 188 U/L, respectively. Activity of this enzyme in patients with cancer involving lower segment of GI tract amounted to 15.9 U/g Hb and 190 U/L of plasma, and was significantly lower (p < 0.001) than in normal subjects in whom it amounted to 21.0 U/g Hb and 256 U/L of plasma.
Asunto(s)
Neoplasias Gastrointestinales/metabolismo , Glutatión Peroxidasa/sangre , Selenio/sangre , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Valores de ReferenciaRESUMEN
Recent prospective epidemiological studies have shown an association between a low prediagnostic serum selenium (Se) concentration and the risk of cancer. Se concentrations in whole blood and plasma, and the activity of red cell and plasma glutathione peroxidase (GSH-Px) were measured in patients with breast cancer, gastric cancer and colorectal cancer. The observed whole blood and plasma Se concentrations of healthy persons were 99.5 and 78.5 micrograms/L, respectively. Red cell and plasma GSH-Px activities of this group were: 21.0 U/g Hb and 256 U/L plasma. In all investigated cancer patients significantly lower whole blood and plasma Se concentrations, and significantly lower red cell and plasma GSH-Px activities were found, as compared with the values of healthy controls. Low Se concentrations of blood components may be indicative of increased cancer risk.
Asunto(s)
Neoplasias de la Mama/sangre , Neoplasias Colorrectales/sangre , Glutatión Peroxidasa/sangre , Selenio/sangre , Neoplasias Gástricas/sangre , Adulto , Anciano , Eritrocitos/enzimología , Femenino , Humanos , Masculino , Persona de Mediana EdadAsunto(s)
Antioxidantes/metabolismo , Peróxido de Hidrógeno/metabolismo , Peroxidación de Lípido/fisiología , Superóxidos/metabolismo , Vitamina E/metabolismo , Catalasa/metabolismo , Radicales Libres , Glutatión Peroxidasa/metabolismo , Humanos , Peróxido de Hidrógeno/antagonistas & inhibidores , Superóxido Dismutasa/metabolismo , Superóxidos/antagonistas & inhibidoresRESUMEN
Malnutrition and septic complications, as well as general anaesthesia, blood transfusion, extent and duration of operation may lead to weakening of the immune system in patients with colonic carcinoma. Complications and related worse prognosis were noted in patients with malnutrition and septic complications. The problems of malnutrition and septic complications in patients operated on for colonic carcinoma may be factors underestimated in surgical practice.