RESUMEN
The correcting action of omegalicin against the background of conventional treatment of psoriasis was investigated. It is established that omegalicin moderately increases the generation of active forms of oxygen needed to suppress the processes of proliferation at the expense of changing the activity of catalase, superoxide dismutase and glutathione peroxidase.
Asunto(s)
Ácidos Grasos Omega-3/administración & dosificación , Oxidación-Reducción/efectos de los fármacos , Psoriasis/terapia , Ácidos Sulfínicos/administración & dosificación , Ácido Ascórbico/administración & dosificación , Catalasa/efectos de los fármacos , Disulfuros , Inducción Enzimática/efectos de los fármacos , Glutatión Peroxidasa/efectos de los fármacos , Humanos , Malondialdehído/sangre , Oxígeno/metabolismo , Compuestos de Sulfhidrilo/sangre , Superóxido Dismutasa/efectos de los fármacosRESUMEN
An experimental model study of the antioxidant properties of imidazole derivatives showed evidence of a nonlinear dose-effect relationship as manifested by hemiluminescence in liposomes. In the in vivo experiments on a thiophenol intoxication model, the antioxidant effect observed for a "large dose-short time" scheme was more favorable than that for a "small dose-long time" administration schedule.
Asunto(s)
Antioxidantes/farmacología , Imidazoles/farmacología , Animales , Antioxidantes/administración & dosificación , Relación Dosis-Respuesta a Droga , Esquema de Medicación , Radicales Libres/metabolismo , Imidazoles/administración & dosificación , Técnicas In Vitro , Liposomas , Mediciones Luminiscentes , Masculino , Microsomas Hepáticos/metabolismo , Oxidación-Reducción , Fenoles/envenenamiento , Ratas , Ratas Wistar , Compuestos de Sulfhidrilo/envenenamientoRESUMEN
Toxic effect of thiophenol on rats can be prevented by injection of antioxidant beta-ionol and clotrimazole, an inductor of phase I and II detoxication enzymes. Both agents increase o-demethylase activity of cytochrome P-450, but do not prevent inhibition of its water-soluble form, and activate cytosol and microsomal glutathione-dependent enzymes. Both agents protected erythrocytes from peroxide damage by thiophenol and simultaneously enhanced its prooxidant effect in the liver.
Asunto(s)
Antioxidantes/farmacología , Hidroxitolueno Butilado/farmacología , Clotrimazol/farmacología , Fenoles/farmacología , Compuestos de Sulfhidrilo/farmacología , Terpenos/farmacología , Animales , Catalasa/metabolismo , Sistema Enzimático del Citocromo P-450/metabolismo , Inducción Enzimática , Membrana Eritrocítica/metabolismo , Radicales Libres/metabolismo , Glutatión Reductasa/metabolismo , Glutatión Transferasa/metabolismo , Hemoglobinas/metabolismo , Masculino , Norisoprenoides , RatasRESUMEN
Experiments were conducted on Wistar rats to study the effect of laser radiation (LR) with a wavelength of 632.8 and 890.0 nm and power of 0.0005-0.005 and 0.003-0.003 W/cm2, respectively, on the action potential (AP) and mechanical contraction of smooth muscle cells, as well as myocardial ATPase activity. LR with a wavelength of 632.8 and 890.0 nm in a dose of 3.0 J/cm2 activates Ca-ATP-ase activity, increases the activity of the myocardial antioxidant system, reduces the Na-Ca current through the membrane, and accelerates the return of Ca2+ into the sarcoplasmic reticulum. LR with a wavelength of 632.8 nm reduces mainly the Ca flow, while LR with a wavelength of 890.0 nm reduces the Na current In a dose of more than 3.0 J/cm2 LR causes a damaging effect manifested by increased Ca2+ current in the slow channels, increase of amplitude, duration of AP and repolarization phase. Synergism of the action of LR with a wavelength of 632.8 and 890.0 nm and that of some antiarrhythmic agents (procainamide, lidocaine, ethmosin, ethacisin, verapamil) was encountered.
Asunto(s)
Corazón/efectos de la radiación , Rayos Láser , Miocardio/citología , Animales , Células Cultivadas , Ratas , Ratas WistarAsunto(s)
Adaptación Fisiológica , Antioxidantes , Sonido , Adaptación Fisiológica/efectos de los fármacos , Animales , Catalasa/sangre , Eritrocitos/enzimología , Glucosafosfato Deshidrogenasa/sangre , Glutatión Reductasa/sangre , Imidazoles/farmacología , Masculino , Ratas , Superóxido Dismutasa/sangreRESUMEN
ACTH, hydrocortisone and cyclic nucleotides levels, beta-receptors sensitivity, lipid peroxidation (LPO), antioxidant system, hemodynamics were investigated in 93 coronary patients without myocardial infarction in the presence of cardiac arrhythmia and after its correction. The clinical and laboratory findings indicate that it is primarily LPO activation and LPO products excessive accumulation in the blood that are responsible for arrhythmia emergence. Experimental data support these results by showing possibility of cardiac arrhythmia onset due to LPO products which raise the density of Na-Ca channels and inhibit the activity of Ca-dependent ATPase.
Asunto(s)
Arritmias Cardíacas/etiología , Enfermedad Coronaria/fisiopatología , Hemodinámica/fisiología , Peroxidación de Lípido/fisiología , Adulto , Anciano , Antioxidantes/metabolismo , Fibrilación Atrial/etiología , Complejos Cardíacos Prematuros/etiología , Enfermedad Coronaria/complicaciones , Humanos , Persona de Mediana Edad , Taquicardia Supraventricular/etiologíaRESUMEN
Overall 93 patients suffering from coronary heart disease /CHD/ (without acute myocardial infarction) complicated by cardiac rhythm impairment were followed up. Investigation of lipid peroxidation (LPO) and of the antioxidant system (AOS) in those patients revealed LPO activation and a decrease of the AOS activity both at the moment of arrhythmia and after its arrest, with the highest LPO activation being seen in the hyper- and hypokinetic hemodynamic variants. The experimental studies have demonstrated a reverse relationship between the rise of LPO products in the blood, LPO activation in myocytes and the onset of arrhythmia because of an increase in the density of Na(+)-Ca++ channels of the membrane, accumulation of those ions by the cell, and an increase of the transmembranous potential at rest. Therefore, to prevent and treat cardiac rhythm impairment in CHD patients, it is necessary to administer the blockers of Na(+)-Ca++ channels (etmozin, ethacizine, verapamil and so forth) and antioxidants that raise the reserve capacity of the AOS, including laser therapy.