RESUMEN
The paper provides the results of intracardiac circulation ultrasound study in 37 preterm neonatal infants, including 24 patients with severe respiratory distress syndrome (RDS), receiving the exogenous surfactant Curosurf in the complex therapy of the disease. A control comprised 12 apparently healthy preterm neonates who had no clinical signs of RDS in the early adaptive period or artificial ventilation (AV). Both groups were similar in the major anthropometric characteristics and gestational age. The objective of this investigation was to make Doppler echocardiographic study of blood flow through all cardiac valves in the newborn with RDS during AV. The investigation indicated that the neonates with severe RDS had increases in peak blood flow velocity and in peak pressure gradient through the valves of the great vessels: the aorta and pulmonary trunk, and abnormal regurgitation flow mainly through the pulmonary arterial valve, which was a sign of intensive hemodynamic adaptation in the acute phase of disease. By the third day of life, some neonatal infants without clinical signs of RDS were observed to have signs of intensive hemodynamic adaptation: increases in peak blood flow velocity and in peak pressure gradient through the valves of the pulmonary trunk. Irrespective of the specific features of the course of an early neonatal period, neonatal infants need Doppler echocardiographic monitoring for the evaluation of intracardiac hemodynamics.
Asunto(s)
Productos Biológicos/uso terapéutico , Ecocardiografía Doppler , Hemodinámica/fisiología , Fosfolípidos/uso terapéutico , Surfactantes Pulmonares/uso terapéutico , Respiración Artificial , Síndrome de Dificultad Respiratoria del Recién Nacido/fisiopatología , Adaptación Fisiológica , Productos Biológicos/administración & dosificación , Velocidad del Flujo Sanguíneo/fisiología , Circulación Coronaria/fisiología , Femenino , Humanos , Recién Nacido , Recien Nacido Prematuro , Masculino , Fosfolípidos/administración & dosificación , Surfactantes Pulmonares/administración & dosificación , Síndrome de Dificultad Respiratoria del Recién Nacido/diagnóstico por imagen , Síndrome de Dificultad Respiratoria del Recién Nacido/tratamiento farmacológico , Índice de Severidad de la EnfermedadRESUMEN
The impact of standardized antimycobacterial treatment versus a complex combination of chemo- and ozonotherapy on the T and B links and specific antituberculous immunity was studied in patients with destructive pulmonary tuberculosis. A course of ozonotherapy was performed in the early intensive phase of antimycobacterial therapy via endovascular injection of ozonized 0.9% NaCl solution. Ozonotherapy used in the early intensive phase of the standardized treatment in patients with destructive pulmonary tuberculosis results in normalization of the count of tuberculin-sensitized T cells and the number of PPD-L proliferating lymphocytes, promotes decreased tuberculin sensitivity, accelerates normalization of humoral immunity (IgM, IgE), and activates the proliferative capacity of T cells in the early periods.
Asunto(s)
Antibióticos Antituberculosos/uso terapéutico , Ozono/uso terapéutico , Tuberculosis Pulmonar/terapia , Quimioterapia Combinada , Humanos , Inmunoglobulina A/inmunología , Inmunoglobulina G/inmunología , Inmunoglobulina M/inmunología , Inyecciones Intravenosas , Ozono/administración & dosificación , Tuberculosis Pulmonar/tratamiento farmacológico , Tuberculosis Pulmonar/inmunologíaRESUMEN
The paper presents the results of serological diagnosis of hemorrhagic fever with renal syndrome (HFRS) and studies of the time course of humoral immunity formation in this disease carried out in 1980-1983 in the Maritime Territory, one of the active HFRS foci.
Asunto(s)
Fiebre Hemorrágica con Síndrome Renal/inmunología , Anticuerpos Antivirales/análisis , Formación de Anticuerpos , Especificidad de Anticuerpos , Técnica del Anticuerpo Fluorescente , Orthohantavirus/inmunología , Fiebre Hemorrágica con Síndrome Renal/diagnóstico , Humanos , Radioinmunoensayo , Pruebas Serológicas , Siberia , Factores de TiempoRESUMEN
The virus of hemorrhagic fever with renal syndrome serologically similar to Hantaan virus was isolated from three rodent species, Ap. peninsulae, Cl. rutilus, Cl. rufocanus, and from human patients in Vero E6 cell culture.
Asunto(s)
Fiebre Hemorrágica con Síndrome Renal/microbiología , Orthohantavirus/aislamiento & purificación , Virus ARN/aislamiento & purificación , Roedores/microbiología , Animales , Animales Salvajes , Anticuerpos Antivirales/análisis , Antígenos Virales/análisis , Epítopos/análisis , Orthohantavirus/inmunología , Fiebre Hemorrágica con Síndrome Renal/inmunología , Humanos , Masculino , Factores de Tiempo , U.R.S.S. , Cultivo de Virus/métodosRESUMEN
The sporadic character of the occurrence of hemorrhagic fever with the renal syndrome in the Primorye Territory has been established. Three rodent species have been found to be spontaneously infected with the causative agent of this disease. Antibodies in patients with this disease are detected at its early stages and persist for a long time after convalescence. The possibility of the formation of a contingent immune to hemorrhagic fever, due to the persons who have had mild and asymptomatic forms of this infection has been shown.