RESUMEN

We have localized several markers in the Xq24-25 region containing DXS12, DXS42 and DXS37 which are closely linked to the X-linked lymphoproliferative syndrome (XLP) locus. A 850-kb restriction map has been established by mapping overlapping YACs and showed that DXS12 and DXS42 are physically linked within about 50 kb. DXS37 is separated from these two loci at a maximum distance of 3,700 kb. Several new probes have been generated which will contribute to further physical mapping of this region.

Asunto(s)

Paseo de Cromosoma , Cromosomas Artificiales de Levadura , Trastornos Linfoproliferativos/genética , Cromosoma X , Sondas de ADN , Electroforesis en Gel de Campo Pulsado , Genes Recesivos , Ligamiento Genético , Marcadores Genéticos , Humanos , Mapeo Restrictivo