RESUMEN
Blindness characterized by dilated, unresponsive pupils and ophthalmoscopic evidence of optic nerve atrophy and retinal degeneration developed in a 5-year-old llama. Lesions were not progressive during 2 months of observation. The llama was euthanatized and necropsied. Histopathologic findings included chorioretinitis, optic neuritis, and encephalitis characterized by mononuclear perivascular infiltration. Attempts to prove an infectious cause were unsuccessful.
Asunto(s)
Artiodáctilos , Ceguera/veterinaria , Camélidos del Nuevo Mundo , Coriorretinitis/veterinaria , Encefalitis/veterinaria , Neuritis Óptica/veterinaria , Animales , Ceguera/etiología , Coriorretinitis/complicaciones , Electrorretinografía/veterinaria , Encefalitis/complicaciones , Ojo/patología , Masculino , Oftalmoscopía/veterinaria , Neuritis Óptica/complicacionesRESUMEN
Clinical, ophthalmoscopic, and histopathologic findings of vitamin A deficiency in a group of 535 feedlot cattle are described. Liver vitamin A content and results of histologic examination of ocular and osseous (optic canal) tissue confirmed the diagnosis. Blindness was the only clinical sign observed. Even though the steers and heifers in this feedlot were approximately the same age and were fed the same ration for an equal period, none of the heifers had overt clinical signs of hypovitaminosis A. Production of vitamin A by the bovine corpus luteum may account for the sexual dimorphism observed in vitamin A-deficient cattle.
Asunto(s)
Ceguera/veterinaria , Enfermedades de los Bovinos , Caracteres Sexuales , Deficiencia de Vitamina A/veterinaria , Animales , Ceguera/etiología , Bovinos , Femenino , Masculino , Deficiencia de Vitamina A/complicacionesRESUMEN
Sequential reciprocals of serum creatinine concentration and sodium sulfanilate clearance half-times were used to monitor a horse with chronic renal failure. The horse was diagnosed as having polycystic kidney disease; at least one cyst was of distal tubular origin. Using the plots of the sequential data, a reasonably accurate prediction was made for complete renal decompensation to develop.
Asunto(s)
Bencenosulfonatos , Creatinina/sangre , Enfermedades de los Caballos/diagnóstico , Fallo Renal Crónico/veterinaria , Enfermedades Renales Poliquísticas/veterinaria , Ácidos Sulfanílicos , Animales , Tasa de Filtración Glomerular , Semivida , Enfermedades de los Caballos/etiología , Caballos , Fallo Renal Crónico/diagnóstico , Fallo Renal Crónico/etiología , Masculino , Enfermedades Renales Poliquísticas/complicaciones , Ácidos Sulfanílicos/farmacocinéticaRESUMEN
We examined the age and breed prevalence and the response to treatment of 19 dogs with nodular granulomatous episclerokeratitis. Biopsy specimens were evaluated to determine the histologic characteristics of the lesions. In these dogs, this disorder was an idiopathic, bilateral disease characterized histologically by the presence of chronic granulomatous inflammation and reticulin fiber formation. The onset of clinical signs developed predominantly in young to middle-aged Collies, with a slow progression and benign clinical course. With treatment, the condition rarely threatened vision and was controlled easily with azathioprine (2 mg/kg) and/or corticosteroid. The dose of immunosuppressive drug was tapered to allow for minimal systemic effects and continued remission of clinical signs. The response to treatment was highly variable.
Asunto(s)
Enfermedades de los Perros/epidemiología , Queratitis/veterinaria , Corticoesteroides/uso terapéutico , Factores de Edad , Animales , Azatioprina/uso terapéutico , Conjuntiva/patología , Conjuntiva/ultraestructura , Córnea/patología , Enfermedades de los Perros/patología , Enfermedades de los Perros/terapia , Perros , Femenino , Estudios de Seguimiento , Granuloma/veterinaria , Queratitis/epidemiología , Queratitis/patología , Queratitis/terapia , Masculino , Microscopía Electrónica , LinajeRESUMEN
Fourteen limbal biopsy specimens from 11 dogs with chronic superficial keratitis (CSK) were examined histologically and immunohistochemically. Ten of the 14 specimens had corneal epithelial hyperplasia and/or atrophy. Eleven of the 14 specimens had thickened epithelial basement membranes. Each specimen had cellular infiltration and lamellar disruption of the stroma. An avidin-biotin immunoperoxidase complex stain was used to detect immunoglobulin (Ig) deposition. Twelve of the 14 specimens stained positive for Ig. The staining pattern was consistent and characterized by diffuse deposition of stain in the superficial conjunctival stroma near the limbus. Four of the 12 Ig-positive specimens also stained positive in the superficial corneal stroma with 1 of these 4 also staining positive along the epithelial cell basement membrane. The diffuse pattern of stain deposition and the absence of staining of specific epithelial structures indicated that CSK is not a classical autoimmune disease similar to any disease in the pemphigus group or similar to systemic lupus erythematosus. Although the results may implicate CSK as an immune-mediated disease, nonspecific factors could not be ruled out.