RESUMEN
Infections and/or severe hemorrhages are the reasons for the unfavorable prognosis in patients with myeloid insufficiency. Hemorrhagic complications may be reduced by thrombocyte transfusions and substitution of coagulation factors; the prevention and treatment of infections represents great problems in spite of newly developed broad spectrum antibiotics. A comparison is made between the therapeutic results of 11 patients treated in sterile units and 22 patients treated under conventional conditions. The rate of remission was seen to be 64% in the first group and 28% in the second.
Asunto(s)
Antineoplásicos/uso terapéutico , Infección Hospitalaria/microbiología , Leucemia/complicaciones , Trastornos Mieloproliferativos/complicaciones , Aisladores de Pacientes , Antibacterianos/efectos adversos , Antibacterianos/uso terapéutico , Infección Hospitalaria/tratamiento farmacológico , Infección Hospitalaria/prevención & control , HumanosRESUMEN
In a group of 44 patients with primary and secondary aplastic anemia, four (9%) developed an acute leukemia. Cytological changes that pointed to a preleukemia were not observed during the preleukemic stage. The possibility is discussed whether a aplastic anemia and a preleukemia can be distinguished by cytological, cytochemical and cytogenetic tests, by agar-culture technique, liquid-culture and determination of reverse transcriptase.
Asunto(s)
Anemia Aplásica/complicaciones , Leucemia/etiología , Enfermedad Aguda , Adulto , Examen de la Médula Ósea , Femenino , Humanos , Leucemia/diagnóstico , Masculino , Persona de Mediana Edad , Lesiones PrecancerosasAsunto(s)
Neoplasias/sangre , Trombocitosis/sangre , Humanos , Lesiones Precancerosas/sangre , SíndromeAsunto(s)
Cuerpos de Inclusión , Leucemia Linfoide/patología , Humanos , Nucleoproteínas/análisis , PronósticoRESUMEN
For the first time a report is given on a case of chronic eosinophilic leukemia with occurence of eosinophilic pulmonary granulomas. Even after enucleation of the granulomas eosinophilia remained in the peripheral blood and in the bone marrow, and over a period of 6 years lay at a value of above 50% of the granulocytes. The illness ended with sudden increase in the number of myeloblasts. The autopsy revealed destruction of the bone marrow by myeloblasts, immature and mature eosinophilic granulocytes as well as infiltration of the heart, liver, spleen and kidneys. On the basis of histological, cytological and histochemical examinations of the granulomas, the peripheral blood and the organs after dissection, particularly of the bone marrow, there was good reason to assume common pathogenesis of these changes; it was not however possible to completely exclude an allergically generated cause.