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BACKGROUND: Advances in chemotherapy have led to increasing major vascular resection during pancreatectomy which has been contraindicated due to high morbidity. This study aimed to verify the safety and oncological outcomes of vascular resection during pancreatectomy in the era of neoadjuvant therapy. METHODS: Data from patients who underwent surgery for pancreatic cancer at Seoul National University Hospital between 2001 and 2021 were reviewed. Clinicopathological outcomes were analyzed according vessel resection. A propensity-score-matched (PSM) analysis was performed to evaluate survival outcomes. RESULTS: Of 1596 patients, the proportion of those who underwent vascular resection increased from 9.2% to 23.4% over time divided into 5-year intervals. There were no differences in major complications (15.6% vs. 13.0%; p = .266) and 30-day mortality rate (0.3% vs. 0.6%; p = .837) between the vascular and nonvascular resection groups. After PSM, the vascular resection group demonstrated comparable survival outcome with the nonvascular resection group (5 year-survival-rate 20.4 vs. 23.7%; p = .194). Arterial resection yielded comparable survival outcome with nonvascular resection (5 year-survival-rate 38.1% vs. 23.7%; p = .138). CONCLUSIONS: Appropriate vascular resection-even arterial-is safe and effective in patients carefully selected for radical surgery in the era of neoadjuvant therapy. Further studies are needed to determine the optimal indication and method for vascular resection in patients with pancreatic cancer.
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Microplastics (MPs) are ubiquitous in the environment, posing a threat to ecosystems and causing increasing concerns regarding their impacts on the human body through exposure. However, there has been limited research on the presence of MPs in functional foods, despite them being consumed for health improvement. This study aimed to investigate MP occurrence in various omega-3 oils and oil products in the Korean market and its relation to the source of raw material or manufacture. MPs were investigated in omega-3 capsules and raw oil, sourced from both plant-based (PB) and animal-based (AB) sources. We developed a method of direct filtration with acetone washing for collecting and characterizing MPs larger than 5 µm using micro-Raman spectroscopy. The average number of MPs by mass was found to be 1.2 ± 1.7 MPs/g for PB raw oil, 2.2 ± 1.7 MPs/g for AB raw oil, 3.5 ± 3.9 MPs/g for PB capsule oil, and 10.6 ± 8.9 MPs/g for AB capsule oil. Polypropylene and polyethylene terephthalate were the major MP species (83-95%) found in omega-3 oil. The proportions based on size range remained consistent across all groups, with a trend of being detected at higher rates as the size decreased. The results reveal that the main reason for the MP contamination of omega-3 oil is not the source of raw material but the manufacturing and packaging process.
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KEY POINTS: Microplastics were identified in nasal irrigations Polypropylenes, which were the main component of the nozzle, were commonly identified Additional studies are needed to understand the biological relevance of microplastics in nasal irrigations.