RESUMEN
Clinical trials of thermoheliox application (inhalation with a high-temperature mixture of oxygen and helium, 90 °C) in the treatment of the acute phase of coronavirus infection were conducted. Dynamics of disease development in infected patients (PCR test for the virus) and, dynamics of changes in blood concentration of C-reactive protein, immunoglobulin M, specific immunoglobulin G were studied. High efficiency of thermoheliox in releasing the organism from the virus and stimulating the immune response (thermovaccination effect) was shown. The kinetic model of the process is proposed and analyzed.
Asunto(s)
COVID-19/inmunología , COVID-19/terapia , Helio/administración & dosificación , Hipertermia Inducida/métodos , Oxígeno/administración & dosificación , Administración por Inhalación , Adulto , Anciano , Anticuerpos Antivirales/sangre , Proteína C-Reactiva/biosíntesis , COVID-19/virología , Calor , Humanos , Inmunoglobulina G/sangre , Inmunoglobulina M/sangre , Cinética , Persona de Mediana Edad , Modelos Inmunológicos , SARS-CoV-2/inmunología , Vacunación/métodosRESUMEN
Kinetic modeling of the behavior of complex chemical and biochemical systems is an effective approach to study of the mechanisms of the process. A kinetic model of coronaviral infection development with a description of the dynamic behavior of the main variables, including the concentration of viral particles, affected cells, and pathogenic microflora, is proposed. Changes in the concentration of hydrogen ions in the lungs and the pH -dependence of carbonic anhydrase activity (a key breathing enzyme) are critical. A significant result is the demonstration of an acute bifurcation transition that determines life or system collapse. This transition is connected with exponential growth of concentrations of the process participants and with functioning of the key enzyme carbonic anhydrase in development of toxic effects. Physical and chemical interpretations of the therapeutic effects of the body temperature rise and the potential therapeutic effect of "thermoheliox" (respiration with a thermolized mixture of helium and oxygen) are given. The phenomenon of "thermovaccination" is predicted, which involves stimulation of the immune response by "thermoheliox".