RESUMEN
This is a prospective, controlled, randomized clinical study to evidence the role of nitrosative stress in development of overt neurological sign of canine distemper (CD). The enrollment of cases wasa made on basis of overt sign of CD (n=139) and the findings were compared with apparently healthy dogs (n=15). The CD specific immunoglobulins resulted in 94 confirmed positive cases. The nitric oxide (NO) and neuronal nitric oxide synthase (nNOS) concentration in cerebrospinal fluid (CSF) (18.08 ± 2.76, 415.84 ± 46.24, respectively) and plasma (32.68 ± 4.31, 321.31 ± 102.30, respectively) were significantly (P<0.05) elevated as compared to healthy control group. The concentration of neuron specific enolase (NSE) in CSF and plasma were also significantly (P<0.05) higher in dogs suffering from CD. The significant differences in other biochemical parameters like total protein, albumin and globulin were found in the CSF of dogs compared with healthy control. The author concludes that NO plays a role in pathophysiology of neurological form of CD and nNOS and NSE estimation in CSF and plasma could help in making early diagnosis of clinical cases.
RESUMEN
Acariotic mange in rabbits is one of the important constraints in rabbit husbandry. Sarcoptes scabies var. cuniculi and Psoroptes cuniculi are most common mites prevailed in rabbits, but Notoedres cati, is the rarest mite ever been reported in rabbit. Two New Zealand white rabbits were presented with clinical signs of pruritus, alopecia, scab and crust formation and lichenification on the upper lip, ear pinnae, eyelids, lower jaw and limbs. Deep skin scraping was taken separately from 4 to 5 different skin lesions from each rabbit, revealed mixed infestations of N. cati, S. cuniculi and P. cuniculi. Subcutaneous injection of ivermectin at weekly intervals for four weeks resulted in remission of clinical signs and improvement of health condition in rabbits. This is the first report of N. cati infestation of rabbit in Odisha.
RESUMEN
Ivermectin is one of the most effective and widely used antiparasitic agents ever discovered because of its broad spectrum activity against nematodes and arthropods. Therefore, the study was conducted to determine the comparative anthelmintic efficacy of ivermectin by giving through oral and subcutaneous routes in clinically infected dogs and also to check the prevalence of gastrointestinal nematode in dogs in Bhubaneswar, Odisha. Total 154 dogs with clinical signs of gastroenteritis were examined for the presence of nematodal ova in their faecal sample and 64 were found positive (41.56 %). The screened dogs were divided in to two groups (n = 10 each), first group of animals were treated with ivermectin @ 0.5 mg/kg body weight by subcutaneous route and the second group with same dose of ivermectin through oral route. Efficacy of ivermectin was evaluated based on egg per gram (EPG), haematological and biochemical parameters. It is concluded that, Prevalence of gastrointestinal nematodes are high in dogs in the climatic condition of Bhubaneswar, Odisha. Ivermectin was found effective when administered through either of the routes. Haemato-biochemical parameters were restored after administration of ivermectin and also significant reduction in EPG was found in dogs treated with ivermectin by both the routes, but no significant difference was observed in EPG between oral and subcutaneous treated dogs in various intervals of study.