RESUMEN
Subcutaneous granuloma annulare is an inflammatory lesion occurring in otherwise healthy children. We present 3 pediatric patients with different diagnostic-therapeutic paths depending on the ward they were referred to. The lesions regress spontaneously, and medical or surgical treatments are generally not necessary.
Asunto(s)
Enfermedades del Tejido Conjuntivo/patología , Granuloma Anular/patología , Brazo/diagnóstico por imagen , Preescolar , Enfermedades del Tejido Conjuntivo/diagnóstico por imagen , Diagnóstico Diferencial , Femenino , Granuloma Anular/diagnóstico por imagen , Humanos , Lactante , Pierna/diagnóstico por imagen , Masculino , Ultrasonografía Doppler en ColorAsunto(s)
Piel/patología , Tiña/diagnóstico , Diagnóstico Diferencial , Humanos , Lactante , Masculino , Piel/microbiología , Tiña/microbiologíaAsunto(s)
Anticuerpos Monoclonales/administración & dosificación , Proteínas Portadoras/genética , Síndromes Periódicos Asociados a Criopirina/tratamiento farmacológico , Inmunosupresores/administración & dosificación , Proteína Antagonista del Receptor de Interleucina 1/administración & dosificación , Interleucina-1beta/antagonistas & inhibidores , Mosaicismo , Anticuerpos Monoclonales Humanizados , Síndromes Periódicos Asociados a Criopirina/diagnóstico , Síndromes Periódicos Asociados a Criopirina/genética , Síndromes Periódicos Asociados a Criopirina/inmunología , Esquema de Medicación , Femenino , Predisposición Genética a la Enfermedad , Humanos , Interleucina-1beta/inmunología , Proteína con Dominio Pirina 3 de la Familia NLR , Fenotipo , Recurrencia , Inducción de Remisión , Factores de Tiempo , Resultado del Tratamiento , Adulto JovenRESUMEN
PURPOSE: Breastfeeding women may suffer from migraine. While we have many drugs for its treatment and prophylaxis, the majority are poorly studied in breastfeeding women. We conducted a review of the most common anti-migraine drugs (AMDs) and we determined their lactation risk. METHODS: For each AMD, we collected all retrievable data from Hale's Medications and Mother Milk (2012), from the LactMed database (2014) of the National Library of Medicine, and from a MedLine Search of relevant studies published in the last 10 years. RESULTS: According to our review, AMDs safe during breastfeeding are as follows: low-dose acetylsalicylic acid (ASA), ibuprofen, sumatriptan, metoprolol, propranolol, verapamil, amitriptyline, escitalopram, paroxetine, sertraline, acetaminophen, caffeine, and metoclopramide. AMDs compatible with breastfeeding but warranting caution are as follows: diclofenac, ketoprofen, naproxen, most new triptans, topiramate, valproate, venlafaxine, and cyproheptadine. Finally, high-dose ASA, atenolol, nadolol, cinnarizine, flunarizine, ergotamine, methysergide, and pizotifen are contraindicated. CONCLUSIONS: According to our review, the majority of the revised AMDs were assessed to be compatible with breastfeeding.
Asunto(s)
Lactancia Materna , Trastornos Migrañosos/tratamiento farmacológico , Antagonistas Adrenérgicos beta/farmacocinética , Antagonistas Adrenérgicos beta/uso terapéutico , Analgésicos no Narcóticos/farmacocinética , Analgésicos no Narcóticos/uso terapéutico , Animales , Antiinflamatorios no Esteroideos/farmacocinética , Antiinflamatorios no Esteroideos/uso terapéutico , Anticonvulsivantes/farmacocinética , Anticonvulsivantes/uso terapéutico , Antidepresivos/farmacocinética , Antidepresivos/uso terapéutico , Bloqueadores de los Canales de Calcio/farmacocinética , Bloqueadores de los Canales de Calcio/uso terapéutico , Femenino , Humanos , Trastornos Migrañosos/metabolismo , Triptaminas/farmacocinética , Triptaminas/uso terapéuticoRESUMEN
OBJECTIVES: Cryopyrin-associated periodic syndromes (CAPS) are a group of chronic, relapsing autoinflammatory disorders which may be complicated by systemic AA amyloidosis. The aim of our study was to evaluate serum amyloid protein A (SAA) level in CAPS patients treated with Interleukin-1beta (IL-1ß) antagonist and to correlate its level with treatment response. METHODS: All patients of CAPS Italian Register treated with IL-1ß inhibitor were enrolled. SAA levels before starting therapy, and at last visit were evaluated. Patients were then divided in complete responders and partial responders. RESULTS: Twenty-five patients were enrolled. SAA level before starting therapy was increased (median 118.5 mg/L, IQR 96.4-252.8; normal value <6.4 mg/L), while at last visit SAA was significantly reduced (median 4.3 mg/L, IQR 2.3-12.7) (p<0.001). However 12 patients still presented SAA levels beyond normal range, 10/25 patients (40%) showed a complete response to treatment. Conversely, 15 patients presented only a partial response, of which 12 for increased SAA value and 3 for increased CRP value. Patients with partial response had SAA values significantly higher than patients with complete response (median 12.6 mg/L; IQR 8.3-20.0 vs. 2.7 mg/L; IQR 1.6-4.1, p<0.001). CONCLUSIONS: Our results confirm the long term efficacy of anti IL-1ß treatment in CAPS and the decrease of SAA levels; however 48% of patients still presented SAA elevation despite treatment. The real risk of these patients in developing amyloidosis is not clear but the persistent increase of SAA needs a close follow-up.
Asunto(s)
Amiloidosis , Síndromes Periódicos Asociados a Criopirina , Monitoreo de Drogas/métodos , Inmunosupresores/uso terapéutico , Interleucina-1beta/antagonistas & inhibidores , Proteína Amiloide A Sérica/metabolismo , Adolescente , Adulto , Amiloidosis/sangre , Amiloidosis/complicaciones , Amiloidosis/tratamiento farmacológico , Niño , Preescolar , Síndromes Periódicos Asociados a Criopirina/sangre , Síndromes Periódicos Asociados a Criopirina/complicaciones , Síndromes Periódicos Asociados a Criopirina/tratamiento farmacológico , Femenino , Humanos , Masculino , Persona de Mediana Edad , Resultado del Tratamiento , Adulto JovenAsunto(s)
Fibroma/patología , Enfermedades del Pie/patología , Femenino , Humanos , Lactante , Dedos del Pie/patologíaRESUMEN
OBJECTIVE: To evaluate the quality of life and long-term follow-up of patients enrolled in the Italian registry of cryopyrin-associated periodic syndromes (CAPS). STUDY DESIGN: Since 2004, 20 patients with CAPS were enrolled in a common registry from different Italian Centers of Pediatric Rheumatology; 14 patients were treated with Anakinra in an open fashion. Both treated and untreated patients were routinely followed according to standard of care. The Child Health Questionnaire (CHQ-PF 50) was used to assess the health-related quality of life. RESULTS: The mean duration of follow-up was 37.5 months. In all treated patients, a complete and persistent control of the inflammatory manifestations was observed with no further progression of the disease. At enrollment in the registry, patients showed a poorer health-related quality of life than healthy children in both physical and the psychosocial summary scores. Treatment was associated with a dramatic and sustained amelioration of a variety of measures of poor quality of life, particularly in those concerning the global health perception, bodily pain-discomfort, and other physical domains. CONCLUSIONS: Long-term IL-1 blockade produces a significant and persistent improvement in the clinical manifestations associated with the disease and on the overall quality of life.