RESUMEN
OBJECTIVES: To evaluate prevalence rates and patterns of permanent tooth agenesis in individuals with non-syndromic Robin sequence (ns-RS). MATERIAL AND METHODS: Two investigators independently carried out a literature search, using PubMed, Web of Science, Ovid, EMBASE and the Cochrane Library, identifying articles relating to permanent tooth agenesis, diagnosed using panoramic radiographs, in individuals with ns-RS. The outcomes desired were prevalence rates and patterns of permanent tooth agenesis. The final search was carried out in January 2017. RESULTS: Six articles were selected for inclusion, with a total of 448 individuals with ns-RS. Data available in each study varied which allowed conducting further specific meta-analyses only on sample sizes of 339 or 378 individuals from three or four of the six included articles. The overall estimated prevalence rate of permanent tooth agenesis was 42% (95% CI: 35%-48%), excluding third molars, with no sex predilection. In individuals with tooth agenesis, approximately 30% had one missing tooth while 40% had two missing teeth. Tooth agenesis was more commonly bilateral (Relative Risk 2) and found in the mandible (Relative Risk 1.6). The highest prevalence of permanent tooth agenesis was found for mandibular second premolars (26%) followed by maxillary second premolars (14%). The most common tooth agenesis patterns were the agenesis of both mandibular second premolars, followed by the agenesis of all second premolars. CONCLUSION: Individuals with ns-RS have high prevalence rates of permanent tooth agenesis. The most prevalent tooth agenesis patterns are bilateral symmetric tooth agenesis, most commonly agenesis of both mandibular second premolars.
Asunto(s)
Anodoncia/epidemiología , Anodoncia/complicaciones , Niño , Preescolar , Femenino , Humanos , Masculino , Síndrome de Pierre Robin/complicaciones , PrevalenciaRESUMEN
AIM: To evaluate caries prevalence in non-syndromic patients with cleft lip and/or palate (CLP) in comparison with a matched non-CLP population. METHODS: A literature search was conducted in order to identify articles reporting on the prevalence of caries in CLP versus non-CLP individuals. The related citations function in PubMed and reference lists of retrieved articles were used to expand the search. Only studies with a suitable matched control group were included. From each included study, study and sample characteristics were extracted, as were results. The main outcome was the score given for caries prevalence in each study, using a well-defined index. The data were entered into meta-analysis software and a meta-analysis performed using the random-effects model. RESULTS: From the 592 articles initially identified, 7 were chosen according to preset inclusion and exclusion criteria. All of the studies were cross-sectional in nature, and used the decayed, missing, and filled (DMF/dmf) indices as the final outcomes. The included studies involved a total of 474 CLP patients aged 1.5-29 years. When looking at permanent teeth, data from 5 studies suggest that CLP patients have a higher number of DMF teeth than the controls (mean difference 1.38; p = 0.003). For deciduous teeth, data from 4 studies suggest that CLP patients have a higher number of dmf teeth than the controls (mean difference 1.51; p = 0.03). CONCLUSION: Non-syndromic patients with CLP tend to have higher caries prevalence, both in the permanent and the deciduous dentition, in comparison with matched non-CLP controls.