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1.
Acta Orthop Traumatol Turc ; 56(5): 311-315, 2022 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-36250879

RESUMEN

OBJECTIVE: This study aimed to find out the level of the gracilis and semitendinosus tendons that would provide the closest information about the size of the quadruple-stranded hamstring autograft using magnetic resonance images before anterior cruciate ligament reconstruction. METHODS: Ninety-six patients (44 males, 52 females) who underwent anterior cruciate ligament reconstruction with quadruple hamstring tendon autografts between January 2015 and March 2020 were retrospectively analyzed. The cross-sectional areas of the gracilis and the semitendinosus tendons at 6 different levels (pes anserinus insertion site, tibial tuberosity, fibular head, tibial plateau, and the proximal insertion sites of the anterior cruciate ligament and the medial collateral ligament were measured on the magnetic resonance images. In addition, the harvested hamstring tendons were measured together (quadrupled) using a standardized graft-sizing block. RESULTS: There was no significant difference between genders in terms of the tendon sizes measured in all levels using magnetic resonance images. There was a strong correlation between the graft size and the measurements made at the tibial plateau level (P < .0001, r=0.590). CONCLUSION: Intraoperative quadruple hamstring tendon sizes were most correlated with the magnetic resonance image measurements at the tibial plateau level. To use a hamstring autograft with a diameter of at least 8 mm for anterior cruciate ligament reconstruction, the total area of the 2 tendons should be at least 18.11 mm2 in the magnetic resonance image measurements made at the tibial plateau level. LEVEL OF EVIDENCE: Level IV, Diagnostic Study.


Asunto(s)
Lesiones del Ligamento Cruzado Anterior , Reconstrucción del Ligamento Cruzado Anterior , Tendones Isquiotibiales , Humanos , Femenino , Masculino , Autoinjertos , Estudios Retrospectivos , Reconstrucción del Ligamento Cruzado Anterior/métodos , Tendones Isquiotibiales/diagnóstico por imagen , Tendones Isquiotibiales/trasplante , Lesiones del Ligamento Cruzado Anterior/diagnóstico por imagen , Lesiones del Ligamento Cruzado Anterior/cirugía , Trasplante Autólogo , Imagen por Resonancia Magnética/métodos
2.
J Foot Ankle Surg ; 61(6): 1299-1302, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35606277

RESUMEN

This study aims to investigate the anatomical factors that are effective in the formation of peroneal tendon tears comparing with the control group. The patients with ankle magnetic resonance imaging (MRI) due to pain on the lateral side of the ankle were retrospectively analyzed using the clinical archive between July 2015 and January 2020. Peroneal tendon tears, peroneal tubercle type and size, presence of peroneal quartus, presence and type of retromalleolar groove, retromalleolar groove area, lateral malleolus type, presence of os peroneum, peroneus brevis-lateral malleolus distance (PBLMD), and accompanying pathologies in coronal, axial, and sagittal planes MRI were evaluated. PBLMD was measured as 27.1 ± 12.3 mm in Group 1. With PBLMD, it was measured as 39.6 ± 11.68 mm in Group 2. There was a significant relationship between low-lying peroneus brevis muscle and peroneal tear (p < .001). Peroneal tendon tear was more common in patients with peroneal quartus muscle (p < .001). There was a relationship between the retromalleolar groove type and the presence of peroneal tear (p = .004). More peroneal tears were observed in the concave retromalleolar groove type. The presence of concave type retromalleolar groove, peroneus quartus, and low-lying peroneus brevis muscle was found to be associated with peroneal tendon tears.

3.
J Orthop Sci ; 27(5): 1132-1138, 2022 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-34384658

RESUMEN

BACKGROUND: We aimed to compare biochemical and histopathological findings of astaxanthin's potential effects on oxidative stress in ischemia/reperfusion damage (I/R). METHODS: Thirty-two rats were randomly divided into four groups: control group; I/R group; I/R + treatment group; drug group. Astaxanthin was orally administered to groups C and D for 14 days. In groups B and C, the femoral artery was clamped for 2 h to form ischemia. The clamp was opened, and reperfusion was performed for 1 h. In all groups, 4 ml of blood sample through intracardiac puncture and gastrocnemius muscle tissue samples were collected. Serum and tissue samples were analyzed by measuring malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant capacity (TAC), and total oxidative level (TOL). Necrosis, inflammation, and caspase-3 in muscle tissue collected for histopathological examination were evaluated. RESULTS: Tissue MDA, SOD and TOL values significantly differed between groups. Serum MDA, SOD, TOL and TAC values significantly differed between groups. On necrosis examination, there was a significant difference between groups B and C. Although signs of inflammation significantly differed between groups, there was no significant difference between groups A and C and groups A and D. Although there was a significant difference in caspase-3 results between groups, there was no significant difference between groups A and C. CONCLUSIONS: The use of astaxanthin before and after surgery showed preventive or therapeutic effects against I/R damage.


Asunto(s)
Daño por Reperfusión , Animales , Antioxidantes/farmacología , Antioxidantes/uso terapéutico , Caspasa 3/metabolismo , Caspasa 3/farmacología , Caspasa 3/uso terapéutico , Inflamación , Necrosis , Estrés Oxidativo/fisiología , Ratas , Daño por Reperfusión/tratamiento farmacológico , Daño por Reperfusión/patología , Daño por Reperfusión/prevención & control , Superóxido Dismutasa/metabolismo , Superóxido Dismutasa/farmacología , Superóxido Dismutasa/uso terapéutico , Xantófilas
4.
Med Sci Monit ; 27: e929709, 2021 Sep 06.
Artículo en Inglés | MEDLINE | ID: mdl-34483334

RESUMEN

BACKGROUND In this study, we aimed to investigate the effects of N-butyl-2-cyanoacrylate (cyanoacrylate) on the biomechanical and histopathological aspects of tendon healing in a rabbit model of Achilles tendon injury. MATERIAL AND METHODS In total, 36 rabbits were randomized to experimental (cyanoacrylate) and control groups (n=36 tendons in each group). A simple suture was used in the control group and a simple suture plus cyanoacrylate was used in the experimental group. Nine rabbits from each group were euthanized at week 4 and week 6 after surgery for histopathological and biomechanical testing. RESULTS Granulation tissue formation was significantly greater in the experimental group in week 4 and week 6 than in the control group. Foreign body giant cell formation was significantly higher in the experimental group in week 4 and week 6. The maximum rupture force was significantly higher in the experimental group in week 4 and week 6 than in the control group. Elasticity and stiffness were comparable between groups in week 4; however, stiffness, but not elasticity, was significantly higher in the experimental group in week 6. CONCLUSIONS In the short term, cyanoacrylate enhanced tendon endurance in both a histopathological and biomechanical manner. We conclude that the early initiation of rehabilitation in patients may be safe in cases of cyanoacrylate use for surgical repair of tendon injury.


Asunto(s)
Tendón Calcáneo/lesiones , Cianoacrilatos/uso terapéutico , Rotura/cirugía , Traumatismos de los Tendones/cirugía , Adhesivos Tisulares/uso terapéutico , Tendón Calcáneo/patología , Animales , Fenómenos Biomecánicos , Masculino , Conejos , Distribución Aleatoria , Rotura/patología , Traumatismos de los Tendones/patología
5.
Jt Dis Relat Surg ; 32(2): 347-354, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34145810

RESUMEN

OBJECTIVES: This study aims to evaluate the effect of adipose-derived stromal vascular fraction (SVF) on osteochondral defects treated by hyaluronic acid (HA)-based scaffold in a rabbit model. MATERIALS AND METHODS: Eighteen white New Zealand rabbits were randomly grouped into the experimental group (n=9) and control group (n=9). In all groups, osteochondral defects were induced on the weight-bearing surfaces of the right femoral medial condyles, and a HA-based scaffold was applied to the defect area with microfractures (MFs). In this study, 1 mL of adipose-derived SVF was injected into the knee joints of the rabbits in the experimental group. For histological and macroscopic evaluation, four rabbits were randomly selected from each group at Week 4, and the remaining rabbits were sacrificed at the end of Week 8. Macroscopic assessments of all samples were performed based on the Brittberg scoring system, and microscopic evaluations were performed based on the O'Driscoll scores. RESULTS: Samples were taken at Weeks 4 and 8. At Week 4, the O'Driscoll scores were significantly higher in the control group than the experimental group (p=0.038), while there was no significant difference in the Brittberg scores between the two groups (p=0.108). At Week 8, the O'Driscoll score and Brittberg scores were statistically higher in the experimental group than in the control group (p=0.008 and p=0.007, respectively). According to the microscopic evaluation, at the end of Week 8, the cartilage thickness was greater in the experimental group, and nearly all of the defect area was filled with hyaline cartilage. CONCLUSION: Application of adipose-derived SVF with MF-HA-based scaffold was better than MF-HA-based scaffold treatment in improving osteochondral regeneration. Therefore, it can be used in combination with microfracture and scaffold to accelerate cartilage regeneration, particularly in the treatment of secondary osteoarthritis.


Asunto(s)
Tejido Adiposo , Cartílago Articular/fisiología , Cartílago Hialino/fisiología , Ácido Hialurónico/uso terapéutico , Regeneración , Viscosuplementos/uso terapéutico , Tejido Adiposo/citología , Animales , Artroplastia Subcondral , Cartílago Articular/lesiones , Fémur , Articulación de la Rodilla , Trasplante de Células Madre Mesenquimatosas , Conejos , Distribución Aleatoria
6.
J Orthop Surg (Hong Kong) ; 28(1): 2309499019895650, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-31908181

RESUMEN

BACKGROUND: Total knee arthroplasty (TKA) operation is an effective treatment method in severe osteoarthritis worldwide. However, the number of patients with chronic pain and functional limitations in the postoperative period will continue to increase. Kinesiphobia is an important factor that affects the functional outcomes postoperatively. The aim of this study is to investigate the effects of intraoperative consciousness of the patients during surgery on kinesiophobia development and early functional outcomes of TKA. METHODS: Sixty patients with the diagnosis of primary knee osteoarthritis were enrolled in the study. Tampa Scale of Kinesiophabia (TSK) was obtained for each patient at multiple time periods. Regional anaesthesia and deep sedation were performed on group 1 (n = 30), while regional anaesthesia and light sedation were performed on group 2 (n = 30). The same surgical procedures were applied to all participants. Functional tests were performed on the patients at the postoperative 2nd and 5th days. Visual Analogue Scale (VAS) scores and knee flexion angles were also measured postoperatively. RESULTS: The mean age of the participants (19 men (31.7%) and 41women (68.3%)) was 67.7 ± 6.7 (54-82) years. TSK ≥ 40 was detected in 18 (30%) patients preoperatively and 33 patients (55%) postoperatively. The number of kinesiophobic patients showed statistically significant increase after operation (20/30 (66.7%)) according to preoperative period (9/30 (30%)) in group 2 (p = 0.003). Postoperative functional scores, knee flexion angles and VAS scores were better in non-kinesiophobic patients. Conclusion: Patient's consciousness during TKA operations is an important factor that interferes with the postoperative kinesiophobia development, which may play a pivotal role affecting the early mobility and functional outcomes.


Asunto(s)
Artroplastia de Reemplazo de Rodilla/métodos , Sedación Consciente/métodos , Articulación de la Rodilla/cirugía , Osteoartritis de la Rodilla/cirugía , Dolor Postoperatorio/prevención & control , Rango del Movimiento Articular/fisiología , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Articulación de la Rodilla/fisiopatología , Masculino , Persona de Mediana Edad , Resultado del Tratamiento
7.
Surg Radiol Anat ; 42(6): 641-645, 2020 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-31529167

RESUMEN

PURPOSE: The position of the patella according to the femur is very important in the evaluation of patella-femoral joint disorders. In 1938, Blumensaat (BS) described the BS line to evaluate the patella femoral congruence. This method is still valuable in clinical use. There is a limited number of studies demonstrating the accuracy of BS method as well as the affected variables. The aim of this study was to evaluate o the age and gender-related changes in the BS line. METHODS: Standard lateral knee radiography was performed to all patients at 30° flexion. The relationship between the BS line and the patella inferior pole was examined and the variability of the measurements according to gender and age groups was investigated by statistical methods. RESULTS: Ninety-five patients (43 men and 52 women) were enrolled in the study. Mean age of the patients were 43.7 ± 14.1 years (48.2 ± 11.7, 37.9 ± 14.8 in women and men, respectively). The BS line was passed through the inferior pole of the patella in only 2 (2.1%) of 95 patients. There was a statistically significant difference (p = 0.041) between BS measurement and gender which was found to be higher in females than males. There was no statistically significant correlation with this distance between the age groups (r = - 0.216, p = 0.427). CONCLUSION: In our study, it was concluded that BS measurement differs according to gender but did not have any difference between different age groups.


Asunto(s)
Artralgia/diagnóstico , Fémur/anatomía & histología , Rótula/anatomía & histología , Articulación Patelofemoral/diagnóstico por imagen , Adulto , Factores de Edad , Femenino , Fémur/diagnóstico por imagen , Humanos , Masculino , Persona de Mediana Edad , Rótula/diagnóstico por imagen , Radiografía/estadística & datos numéricos , Factores Sexuales , Adulto Joven
8.
Eklem Hastalik Cerrahisi ; 30(3): 259-66, 2019 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-31650923

RESUMEN

OBJECTIVES: This study aims to evaluate the potential effects of pentoxifylline (PTX) on tendon healing and to compare the histopathological and biomechanical findings of the healed tendon among the groups. MATERIALS AND METHODS: The study was conducted on 36 male New Zealand albino rabbits (age, 3 months; weighing, 2.5±0.5 kg). Rabbits were randomized into two groups of 18 rabbits each. Partial Achilles tenotomy was performed 1.5 cm proximally from the calcaneal insertion of the tendon in both lower extremities of each rabbit and all groups were repaired primarily. After the operation, saline was injected intramuscularly to the control group and PTX was injected into the PTX group daily. Nine rabbits from each group were euthanized at weeks four and six postoperatively for histopathological (n=4) and biomechanical (n=5) testing. The histopathological findings were evaluated using the staging method of Curtis and Delee. Biomechanical effects were assessed by tensile testing. RESULTS: In the biomechanical evaluation results, the maximum displacement and maximum breaking force in the PTX group at fourth week were significantly higher than the control group. In the sixth week, the maximum breaking force in the control group was significantly higher than the PTX group. In the histopathological examination, collagen fiber alignment was more regular and vascularization was more frequent in the PTX group at both fourth and sixth weeks and the difference was significant. CONCLUSION: Pentoxifylline increased healing and strength in rabbit Achilles tendon by stimulating collagen synthesis, increasing vascularity and reducing inflammation, particularly in the early period both histopathologically and biomechanically. According to our study, PTX may be favorable for the treatment of human Achilles tendon injuries and tendinopathies.


Asunto(s)
Tendón Calcáneo/lesiones , Pentoxifilina/farmacología , Inhibidores de Fosfodiesterasa/farmacología , Traumatismos de los Tendones/cirugía , Cicatrización de Heridas/efectos de los fármacos , Animales , Fenómenos Biomecánicos , Masculino , Modelos Animales , Conejos , Distribución Aleatoria , Tenotomía
9.
J Orthop Surg Res ; 14(1): 105, 2019 Apr 15.
Artículo en Inglés | MEDLINE | ID: mdl-30992060

RESUMEN

BACKGROUND: Microfracture and scaffold application in the treatment of osteochondral defects is still one of the most frequently used methods in the clinic. The most important step in this treatment method is the stabilization of fibrin clot. Tranexamic acid (TA) is an antifibrinolytic agent commonly used in orthopedic surgery in recent years. This study evaluated the effect of local TA application on healing of experimentally induced osteochondral defects on rabbits. METHODS: This paper contains an animal in vivo data and histological outcomes on the effect of TA. Eighteen New Zealand white rabbits were treated unilaterally and cylindrical defects having a width of 4 mm and depth of 5 mm were created in the weight-bearing surfaces of the medial and lateral condyles of the right femur. They were divided into two groups, as group 1 study and group 2 control groups, respectively. One milliliter (ml) of TA was injected into the knee joints of the subjects in group 1. All animals were sacrificed for the extraction of the femur condyles for histologic study at the fourth and eighth weeks after surgery. Histological evaluations were performed by Brittberg and O'Driscoll scores to all samples. Data were organized in a Standard Statistical Package System v.22 software package (SPSS/PC Inc., Chicago, IL.) and reported as mean and median (min-max). Repeated measures ANOVA test was used to compare groups and condyle effects together for each week. p values below 0.05 were considered as statistically significant. RESULTS: Samples were taken in the fourth and eighth weeks. The regularity of the surface in group 1 was smoother, and the tissue stability was more robust. Mean Brittberg scores in both weeks were statistically higher in group 1 when compared with group 2. In the microscopic evaluation, it was observed that the regeneration of subchondral and cartilage tissues were more rapid and organized in group 1, and the mean O' Driscoll scores in both weeks were statistically higher in group 1. CONCLUSIONS: Application of TA improves the healing time and tissue stability in osteochondral defects which are implanted a-cellular scaffold after microfracture and should be applicable to humans for the treatment of osteochondral defects.


Asunto(s)
Antifibrinolíticos/administración & dosificación , Fémur/cirugía , Fracturas por Estrés/cirugía , Recuperación de la Función , Andamios del Tejido , Ácido Tranexámico/administración & dosificación , Animales , Fémur/efectos de los fármacos , Fémur/lesiones , Fracturas por Estrés/tratamiento farmacológico , Fracturas por Estrés/patología , Conejos , Recuperación de la Función/efectos de los fármacos , Andamios del Tejido/tendencias , Resultado del Tratamiento
10.
Trauma Case Rep ; 17: 48-51, 2018 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-30310848

RESUMEN

Hip is a stabilized joint due to the surrounding ligaments, and muscles, which can dislocate as a result of high energy trauma, high-level falls, and motor vehicle accidents. Traumatic hip dislocations can either be isolated or simultaneously with acetabular and proximal femur fractures. At the same time injury of sciatic, femoral or obturator nerves can be seen. However, avascular necrosis of femoral head, posttraumatic osteoarthritis, and heterotopic ossifications can be seen as prolonged complications. The period prior to the reduction, severity of the trauma, and performing open or close reductions are the major contributors of the prognosis. As an extremely rare entity, bilateral asymmetrical hip dislocations are reported as the 0.01-0.02% of all joint dislocations. Accompanying proximal femoral fractures are pointed out 17%, one of them is femoral head fractures which are orthopedic emergencies that need to be fixed with surgery. However, high incidence of AVN is reported at the end of 2 years even if following early reductions. In our article, traumatic bilateral asymmetric hip dislocations and femoral head fracture is described in the context of a diagnosis, treatment and follow-up.

11.
Korean J Anesthesiol ; 67(2): 90-5, 2014 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-25237444

RESUMEN

BACKGROUND: Although regional anesthesia is the first choice for patients undergoing total knee arthroplasty (TKA), it may not be effective and the risk of complications is greater in patients who are obese or who have spinal deformities. We compared the success of ultrasound-guided femoral and sciatic nerve blocks with sedoanalgesia versus spinal anesthesia in unilateral TKA patients in whom spinal anesthesia was difficult. METHODS: We enrolled 30 patients; 15 for whom spinal anesthesia was expected to be difficult were classified as the block group, and 15 received spinal anesthesia. Regional anesthesia was achieved with bupivacaine 62.5 mg and prilocaine 250 mg to the sciatic nerve, and bupivacaine 37.5 mg and prilocaine 150 mg to the femoral nerve. Bupivacaine 20 mg was administered to induce spinal anesthesia. Hemodynamic parameters, pain and sedation scores, and surgical and patient satisfaction were compared. RESULTS: A sufficient block could not be obtained in three patients in the block group. The arterial pressure was significantly lower in the spinal group (P < 0.001), and the incidence of nausea was higher (P = 0.017) in this group. Saturation and patient satisfaction were lower in the block group (P < 0.028), while the numerical pain score (P < 0.046) and the Ramsay sedation score were higher (P = 0.007). CONCLUSIONS: Ultrasound-guided sciatic and femoral nerve blocks combined with sedoanalgesia were an alternative anesthesia method in selected TKA patients.

12.
Int J Clin Pharmacol Ther ; 51(8): 652-9, 2013 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-23782581

RESUMEN

BACKGROUND: Providing sufficient and convenient analgesia is crucial during the postoperative period after totalknee replacement (TKR) to enhance patient mobility and reduce stress response to surgery. The scope of this study is to compare the effects of levobupivacaine and levobupivacaine plus fentanyl on stress response and analgesic efficiency after TKR. METHOD: In this study, 40 ASA I - II patients scheduled to undergo TKR were subjected to combined spinal epidural anesthesia (CSEA) injecting of 15 mg levobupivacaine and randomly assigned to receive either levobupivacaine 0.125% (Group L) or levobupivacaine 0.125% plus fentanyl 4 µg ml-1 (Group F) during postoperative period via the epidural route. Patient controlled epidural analgesia (PCEA) was offered for 24 hours. Venous blood samples were assayed for adrenocorticotropic hormone (ACTH), cortisol and prolactin levels before surgery and after analgesia administration. Analgesia was assessed using a visual analogue scale (VAS) at rest (VASR) and during movement (VASM). RESULTS: There was no statistically significant difference between the groups in terms of total doses, bolus requests, bolus delivered and side effects (p > 0.05). The ACTH, cortisol and prolactin levels increased following the surgery and decreased during PCA infusion in both groups where the decline in Group F was significant (p < 0.05) at 24 hours after the analgesic treatment and 48 hours after the surgery. CONCLUSION: We have demonstrated that infusion of levobupivacaine (0.125%) in combination with fentanyl (4 µg ml-1) using PCEA suppressed stress response to surgery significantly and provided better pain relief than levobupivacaine (0.125%) alone after TKR.


Asunto(s)
Analgesia Epidural , Analgesia Controlada por el Paciente , Anestésicos Locales/administración & dosificación , Artroplastia de Reemplazo de Rodilla , Fentanilo/administración & dosificación , Dolor Postoperatorio/tratamiento farmacológico , Hormona Adrenocorticotrópica/sangre , Anciano , Bupivacaína/administración & dosificación , Bupivacaína/análogos & derivados , Método Doble Ciego , Femenino , Frecuencia Cardíaca/efectos de los fármacos , Humanos , Hidrocortisona/clasificación , Levobupivacaína , Masculino , Prolactina/sangre , Estudios Prospectivos
13.
Middle East J Anaesthesiol ; 21(1): 93-8, 2011 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-21991739

RESUMEN

BACKGROUND: In this prospective study we aimed at examining the effects of pneumatic tourniquet on intraocular pressure during elective knee surgery. METHOD: Twenty patients undergoing elective knee surgery under general anesthesia with tracheal intubation were inluded the study. Anesthesia was induced with pentothal, rocuronium and fentanyl, then maintained with sevoflurane and nitrous oxide in oxygen. Intraocular pressure measurements were performed at 7 time points; awake (baseline), following induction, following tracheal intubation, just before tourniquet inflation, after the inflation of tourniquet, before tourniquet deflation, after the deflation of the tourniquet. RESULTS: Baseline IOP was 15 +/- 1 mmHg. Following the induction of anesthesia IOP was reduced significantly (12 +/- 1 mmHg) (p < 0.05), then increased to 16 +/- 1 mmHg after tracheal intubation (p < 0.05). IOP was significantly higher after tourniquet inflation compared with just before (13 +/- 1 mmHg vs 16 +/- 1 mmHg recpectively) (p < 0.05). There was no significant difference between the IOP measurements after the inflation and before the deflation of the tourniquet (p > 0.05). The lowest value was 12 +/- 0 mmHg measured after the tourniquet loosened and it was significant compared with the baseline and the measurement performed before deflation of the tourniquet (16 +/- 0 mmHg) (p < 0.05). CONCLUSION: Pneumatic tourniquet may cause a significant IOP increase in patients performing knee surgery under general anesthesia.


Asunto(s)
Presión Intraocular , Rodilla/cirugía , Torniquetes , Presión Sanguínea , Femenino , Frecuencia Cardíaca , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos
14.
Eklem Hastalik Cerrahisi ; 22(1): 43-7, 2011.
Artículo en Inglés | MEDLINE | ID: mdl-21417986

RESUMEN

OBJECTIVES: In this study we evaluated the effects of montelukast, a leukotriene-receptor antagonist, on fracture healing, and investigated the hypothesis that enhanced fracture healing would be observed with montelukast in a rat tibia fracture model. MATERIALS AND METHODS: Sixty adult (6 months old) female Wistar albino rats (mean weight 220 g, range 210-270 g) were randomly divided into two groups: a montelukast group (n=30) and a control group (n=30). Closed tibia fractures were created and fixed by intramedullary Kirschner wire. The rats were sacrificed three and six weeks after the fractures. Radiological and histological evaluations were performed, and bone mineral density was measured. RESULTS: Three rats died in the montelukast group, whereas only one died in the control group during the study. Initial weight and weight gain at the 3rd and 6th weeks were not significantly different between the groups (p>0.05). Bone mineral densities in the control and study groups were 0.13±0.009 gr/cm2, and 0.13±0.01 gr/cm2 at week three and 0.16±0.02 gr/cm2, and 0.13±0.01 gr/cm2 at week six, respectively. Histopathological scores in the control and study groups were 3.42±0.6, and 3.0±0.0 at week three and 3.5±0.5, and 3.4±0.8 at week six, respectively. Radiological scores in the control and study groups were 1.19±0.6, and 1.0±0.6 at week three and 3.0±0.8, and 2.9±0.9 at week six, respectively. There were no significant differences between the two groups in any parameters evaluated at either time interval (p>0.05). CONCLUSION: Our study failed to show a possible positive effect of leukotriene receptor inhibition on fracture healing at the 3rd and 6th postoperative weeks.


Asunto(s)
Acetatos/farmacología , Curación de Fractura/efectos de los fármacos , Fracturas Cerradas/tratamiento farmacológico , Antagonistas de Leucotrieno/farmacología , Quinolinas/farmacología , Fracturas de la Tibia/tratamiento farmacológico , Absorciometría de Fotón , Animales , Densidad Ósea/efectos de los fármacos , Ciclopropanos , Femenino , Fracturas Cerradas/diagnóstico por imagen , Fracturas Cerradas/patología , Distribución Aleatoria , Ratas , Ratas Wistar , Sulfuros , Fracturas de la Tibia/diagnóstico por imagen , Fracturas de la Tibia/patología , Resultado del Tratamiento
15.
J Orthop Res ; 29(1): 138-42, 2011 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-20726035

RESUMEN

The aim of this study was to evaluate the effect of strontium ranelate (SrR) on fracture healing in the osteoporotic rat model. Forty female Sprague-Dawley rats aged 3 months were enrolled in the study. Osteoporosis was induced by bilateral ovariectomy and subsequent daily heparin injection started 1 week after surgery and lasted for 4 weeks. Osteoporosis was confirmed by a reduction of bone mineral density (BMD). Twenty of the osteoporotic rats were assigned to the SrR group and the remaining 20 to the control group. An open right tibial midshaft transverse fracture was created and then an intramedullary fixation was performed. SrR group was treated by 450 mg/kg/day SrR per oral. Six weeks after surgical induction of fracture, all animals were sacrificed. One animal from each group died after ovariectomy. Two tibiae from the control group failed to unite. SrR-treated group showed higher mechanical strength and fracture stiffness when compared to the control group (p = 0.006, p = 0.001, respectively). SrR-treated group had mature woven bone or predominantly woven bone compared with osteoporotic control group (p = 0.038). SrR-treated group's callus maturity was significantly higher than control group (p = 0.001). SrR is associated with better fracture healing in the osteoporotic rat model.


Asunto(s)
Conservadores de la Densidad Ósea/farmacología , Curación de Fractura/efectos de los fármacos , Compuestos Organometálicos/farmacología , Fracturas Osteoporóticas/fisiopatología , Tiofenos/farmacología , Animales , Fenómenos Biomecánicos , Densidad Ósea/efectos de los fármacos , Modelos Animales de Enfermedad , Femenino , Ratas , Ratas Sprague-Dawley
16.
J Orthop Res ; 28(10): 1368-72, 2010 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-20839321

RESUMEN

Treatment of implant-related chronic osteomyelitis is often difficult and usually consists of implant removal, extensive surgical debridement, and prolonged antibiotic use. This study was performed to assess the efficacy of moxifloxacin compared to a glycopeptide, teicoplanin in chronic implant-related methicillin-sensitive Staphylococcus aureus (MSSA) osteomyelitis. The left femoral medullar cavities of 60 Wistar male rats were contaminated with 100 µl of 10(8) cfu/ml methicillin-sensitive S. aureus (ATCC 29213) and Kirschner wires were placed into the medulla of the femur. After 6 weeks, rats were randomly divided into five groups. In two groups, the Kirschner wires were removed. Experimental groups were as follows: group 1: contaminated, Kirschner wire inside, received teicoplanin; group 2: contaminated, Kirschner wire removed, received teicoplanin; group 3: contaminated, Kirschner wire inside, received moxifloxacin; group 4: contaminated, Kirschner wire removed, received moxifloxacin; group 5: contaminated, Kirschner wire inside, no antibiotics (control group). Groups 1 and 2 received teicoplanin (20 mg/kg once daily), whereas groups 3 and 4 received moxifloxacin (10 mg/kg twice daily) intraperitoneally for 28 days. At the end of the treatment, animals were sacrificed by inhalation anesthesia with ether and femora were retrieved and bacterial counts (cfu/g) were determined. Bacterial counts in all study groups were significantly reduced relative to the control. The decrease of bacterial counts was more prominent in group 4 compared to group 1 (p = 0.001) and group 2 (p = 0.003). Moxifloxacin therapy is an effective alternative to teicoplanin for chronic implant-related MSSA osteomyelitis.


Asunto(s)
Antibacterianos/uso terapéutico , Compuestos Aza/uso terapéutico , Osteomielitis/tratamiento farmacológico , Infecciones Relacionadas con Prótesis/tratamiento farmacológico , Quinolinas/uso terapéutico , Teicoplanina/uso terapéutico , Animales , Antibacterianos/administración & dosificación , Compuestos Aza/administración & dosificación , Enfermedad Crónica , Modelos Animales de Enfermedad , Fluoroquinolonas , Inyecciones Intraperitoneales , Masculino , Moxifloxacino , Osteomielitis/microbiología , Infecciones Relacionadas con Prótesis/complicaciones , Quinolinas/administración & dosificación , Ratas , Ratas Wistar , Infecciones Estafilocócicas/complicaciones , Infecciones Estafilocócicas/tratamiento farmacológico , Staphylococcus aureus , Teicoplanina/administración & dosificación , Resultado del Tratamiento
18.
J Am Podiatr Med Assoc ; 100(2): 105-10, 2010.
Artículo en Inglés | MEDLINE | ID: mdl-20237361

RESUMEN

BACKGROUND: The aim of this study was to evaluate the results of high-dose extracorporeal shockwave therapy applied with an ankle block and corticosteroid injection in patients with plantar fasciitis whose symptoms persisted for more than 6 months. METHODS: Sixty patients were assessed clinically at presentation and at 3-month follow-up with a patient-assessed 100-mm visual analog scale of pain and a physician-assessed heel tenderness index. A therapeutic response rate was evaluated. A decrease of at least 50% from baseline to 3 months in visual analog scale or heel tenderness index scores was accepted as a successful result. RESULTS: Extracorporeal shockwave therapy and corticosteroid injection provided significant improvements in visual analog scale and heel tenderness index scores, but between the two groups there was no significant difference in the visual analog scale score change 3 months after treatment (P > .05). Twenty-seven of 33 patients (82%) in the extracorporeal shockwave therapy group and 23 of 27 (85%) in the corticosteroid injection group had a successful therapeutic response after 3 months. CONCLUSIONS: Corticosteroid injection and extracorporeal shockwave therapy are successful treatment modalities for plantar fasciitis. Corticosteroid injection treatment is cost effective compared with extracorporeal shockwave therapy, and corticosteroid injection may be the first treatment choice according to these results.


Asunto(s)
Corticoesteroides/administración & dosificación , Fascitis Plantar/terapia , Ondas de Choque de Alta Energía/uso terapéutico , Adulto , Anciano , Fascitis Plantar/diagnóstico , Femenino , Estudios de Seguimiento , Humanos , Inyecciones Intralesiones , Masculino , Persona de Mediana Edad , Dimensión del Dolor , Satisfacción del Paciente , Probabilidad , Estudios Prospectivos , Medición de Riesgo , Índice de Severidad de la Enfermedad , Estadísticas no Paramétricas , Resultado del Tratamiento
19.
Orthopedics ; 33(2): 84-91, 2010 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-20192142

RESUMEN

Lateral epicondylitis is a common disorder characterized by pain and tenderness over the lateral epicondyle. It occurs most frequently as a result of minor, unrecognized trauma during sports activities and occupation-related physical activities. The goal of this study was to evaluate the short-, medium-, and long-term effects of corticosteroid injection, autologous blood injection, and extracorporeal shock wave therapy in the treatment of lateral epicondylitis.Sixty patients (32 women, 28 men) with lateral epicondylitis were randomly divided into 3 groups: group 1 received a corticosteroid injection; group 2, an autologous blood injection, and group 3, extracorporeal shock wave therapy. Thomsen provocative testing, upper extremity functional scores, and maximal grip strength were used for evaluation. Outcomes were assessed at 4, 12, 26, and 52 weeks. Corticosteroid injection gave significantly better results for all outcome measures at 4 weeks; success rates in the 3 groups were 90%, 16.6%, and 42.1%, respectively. Autologous blood injection and extracorporeal shock wave therapy gave significantly better Thomsen provocative test results and upper extremity functional scores at 52 weeks; the success rate of corticosteroid injection was 50%, which was significantly lower than the success rates for autologous blood injection (83.3%) and extracorporeal shock wave therapy (89.9%). Corticosteroid injection provided a high success rate in the short term. However, autologous blood injection and extracorporeal shock wave therapy gave better long-term results, especially considering the high recurrence rate with corticosteroid injection. We suggest that the treatment of choice for lateral epicondylitis be autologous blood injection.


Asunto(s)
Corticoesteroides/administración & dosificación , Transfusión de Sangre Autóloga/métodos , Litotricia/métodos , Codo de Tenista/diagnóstico , Codo de Tenista/terapia , Adulto , Terapia Combinada , Femenino , Humanos , Masculino , Persona de Mediana Edad , Resultado del Tratamiento
20.
J Med Case Rep ; 4: 47, 2010 Feb 09.
Artículo en Inglés | MEDLINE | ID: mdl-20181137

RESUMEN

INTRODUCTION: Patellar tendon ossification is a rare pathology that may be seen as a complication after sleeve fractures of the tibial tuberosity, total patellectomy during arthroplasty, intramedullary nailing of tibial fractures, anterior cruciate ligament reconstruction with patellar tendon autograft and knee injury without fracture. However, its occurrence after partial patellectomy surgery has never been reported in the literature. CASE PRESENTATION: We present the case of a 35-year-old Turkish man with a comminuted inferior patellar pole fracture that was treated with partial patellectomy. During the follow-up period, his patellar tendon healed with ossification and then ruptured from the inferior attachment to the tibial tubercle. The ossification was excised and the tendon was subsequently repaired. CONCLUSION: To the best of our knowledge, this is the first report of patellar tendon ossification occurring after partial patellectomy. Orthopaedic surgeons are thus cautioned to be conscious of this rare complication after partial patellectomy.

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