1.
Org Biomol Chem
; 16(44): 8477-8480, 2018 11 14.
Artículo
en Inglés
| MEDLINE
| ID: mdl-30375616
RESUMEN
The first total synthesis of racemic chondrosterin I was accomplished. The synthetic features include a Michael addition to incorporate a nitro alkane moiety, an oxidative Nef reaction, intramolecular cyclization of the γ-ketoester derivative, and a desymmetric intramolecular aldol reaction of the meso diketoester compound. The present strategy will be applicable to the synthesis of an optically active form by asymmetric desymmetrization.