RESUMEN
Medroxyprogesterone acetate is the most commonly used progestin component of hormone therapy. The goal of the present study was to determine whether Medroxyprogesterone affects rat behavior using a Y-maze test. Twenty-four female Wistar rats were randomly selected into three groups; control group, a low dose (13 mg/ml MPA) group and a high dose (33 mg/1 ml MPA) group. Doses of Medroxyprogesterone were delivered by intramuscular injection for a period of 3 weeks. Medroxyprogesterone administration resulted in a decrease in memory and locomotion activity of rats (p < 0.05). Despite Medroxyprogesterone being effective in modulating hormonal interaction to prevent conception in actively reproducing females, cognitive impairment could be one of its adverse effects.
Asunto(s)
Aprendizaje por Laberinto/efectos de los fármacos , Acetato de Medroxiprogesterona/farmacología , Desempeño Psicomotor/efectos de los fármacos , Animales , Femenino , Aprendizaje por Laberinto/fisiología , Desempeño Psicomotor/fisiología , Ratas , Ratas WistarRESUMEN
BACKGROUND: A study of high school students attending a missionary school and a public school in Lagos was carried out to determine their knowledge and attitude about HIV/AIDS and to compare their sexual behaviour. METHODS: Self administered questionnaires, were used for the respondents, selected by multistage sampling and a response rate of 98% was obtained. The average age of the population was 13.6 years. There was no significant difference in the knowledge of students from both schools about HIV/AIDS. 90% of all the respondents knew the exact meaning of HIV/AIDS. Most of the students got their information from the mass media (66%) and the school (57%). Only 5% and 0.3% of missionary and public school students respectively were informed by their parents. RESULTS: There was no significant statistical association between the type of school and the occurrence of sexual intercourse. However, only 4% of sexually active missionary students used condoms compared to the 37% of the public school students. Condom usage was associated with the type of school (X2 = 1830; P-value = 0.0000189). There was also a statistically significant relationship between condom use and the age, sex and class of sexually active students (P-value = 0.00000006; 0.00000032; 0.00497073 respectively). 25% of the sexually public students had multiple sexual partners, compared to 2% for the missionary school students. There was a statistically significant relationship between the type of school and the number of sexual partners (X2 = 11.37; P-value = 0.003390). CONCLUSION: The study recommends that age-appropriate comprehensive sexuality education (including condom use) should be made available to students from both schools.