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1.
Chronobiol Int ; 18(4): 657-64, 2001 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-11587088

RESUMEN

The variation in spontaneous meal patterning was studied in three genotypes (tau +/+, tau +/- and tau -/-) of the Syrian hamster with an altered circadian period. Feeding activity was monitored continuously in 13 individuals from each genotype in constant dim light conditions. All three genotypes had on average six feeding episodes during the circadian cycle (about 20h in homozygous tau mutants and 22h in heterozygotes compared with 24h in wild-type hamsters). Thus, homozygous tau mutant hamsters had significantly more feeding episodes per 24h than wild types, and heterozygotes were intermediate. The average duration of feeding bouts (FBs) was indistinguishable (around 30 minutes) among the three genotypes, whereas the intermeal (IM) intervals were significantly shorter for homozygote tau mutant hamsters (99 minutes), intermediate for heterozygotes (116 minutes), and the longest for wild-type hamsters (148 minutes). Thus, the meal-to-meal duration was on average 25% shorter in homozygous tau mutants (16% in heterozygous) than in wild-type hamsters. The reduction of the circadian period has a pronounced effect on short-term feeding rhythms and meal frequency in hamsters carrying the tau mutation.


Asunto(s)
Relojes Biológicos/fisiología , Ritmo Circadiano/fisiología , Conducta Alimentaria/fisiología , Análisis de Varianza , Animales , Animales Modificados Genéticamente , Cricetinae , Genotipo , Masculino , Mesocricetus , Mutación , Fotoperiodo
2.
Psychoneuroendocrinology ; 22(3): 155-68, 1997 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-9203226

RESUMEN

The behavioural and physiological consequences of a single social defeat were studied in Roman high-avoidance (RHA) and Roman low-avoidance (RLA) rats, two rat lines with a genetically determined difference in the way of responding to or coping with stressors. Animals were subjected to social defeat by placing them in the cage of an aggressive male conspecific for 1 h. In both RHA and RLA rats, social defeat induced a profound increase in body temperature during the circadian resting phase, lasting for up to 10 days after the conflict. The increase in resting temperature was paralleled by a slight decrease in spontaneous home cage activity. Food intake and growth were suppressed for a number of days, resulting in a long-lasting lower body weight compared to non-stressed control animals. An open field test 2 days after defeat showed a social stress-induced decrease in locomotion in a novel environment. Despite the well-known differentiation between RHA and RLA rats in their behavioural and neuroendocrine response pattern to acute environmental challenges, the present study did not show major differences in the long-term consequences of social defeat.


Asunto(s)
Nivel de Alerta/genética , Reacción de Prevención/fisiología , Conducta Animal/fisiología , Dominación-Subordinación , Genotipo , Animales , Regulación de la Temperatura Corporal/genética , Peso Corporal/genética , Ritmo Circadiano/genética , Ingestión de Alimentos/genética , Conducta Exploratoria/fisiología , Masculino , Actividad Motora/fisiología , Ratas , Medio Social
3.
Physiol Behav ; 60(1): 115-9, 1996 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-8804650

RESUMEN

The long-term consequences of a single social defeat on open field behaviour in rats were studied, with special emphasis on the time course of stress-induced changes. Animals were subjected to social defeat by placing them into the territory of an aggressive male conspecific for 1 h. After the defeat session experimental animals were returned to their home cage and their own room, receiving no further cues from the resident. Other animals serving as controls were placed in a clean and empty cage for 1 h. Five-minute open field tests were performed on days 1, 2, 7, 14, and 28 after defeat, with independent groups of rats. Locomotion of the animals was recorded and analyzed with an automated video system. Social defeat resulted in a strong subsequent reduction in open field activity, which lasted till at least 7 days after the conflict. Differences in total travelled distance were no longer significant 2 weeks after the conflict. The latency for moving to the outer ring of the open field arena after the start of the test was still significantly longer 4 weeks after defeat. The stress-induced reduction in open field locomotion could be reversed by 12-h sleep deprivation during the resting phase, an intervention known to have antidepressant effects in humans. Possible relevance of the present findings with respect to human affective disorders is discussed.


Asunto(s)
Agresión/psicología , Conducta Agonística , Dominación-Subordinación , Conducta Exploratoria , Actividad Motora , Privación de Sueño , Afecto , Animales , Nivel de Alerta , Masculino , Ratas , Ratas Endogámicas , Tiempo de Reacción
4.
J Biol Rhythms ; 5(1): 1-16, 1990.
Artículo en Inglés | MEDLINE | ID: mdl-2133115

RESUMEN

The wheel-running activity rhythm of tree shrews (tupaias; Tupaia belangeri) housed in constant darkness (DD) phase-advanced following a 3-hr light pulse at circadian time (CT) 21. Dark pulses of 3 hr presented to tupaias in bright constant light (LL) did not induce significant phase shifts of the free-running activity rhythm, irrespective of the CT. In dim LL, tupaias showed simultaneous splitting of their circadian rhythm of wheel-running activity, nest-box activity, and feeding behavior. Light pulses of 6 hr and 2300 lux were presented to 13 tupaias with split wheel-running activity rhythms. These light pulses induced immediate phase shifts in the two components of the split rhythm in opposite directions. No differences were observed between the light-pulse phase response curves of the two components. Equally large immediate phase advances were induced in both components by light pulses of 230 lux, but not by 23 lux. The final phase shifts were small at all CTs. In two tupaias, activity rhythms transiently split and re-fused. Analysis of the relative position of the components in one of these indicates asymmetry in the coupling between the components.


Asunto(s)
Ritmo Circadiano/fisiología , Oscuridad , Luz , Tupaia/fisiología , Animales , Femenino , Masculino , Actividad Motora/fisiología
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