1.
J Org Chem
; 89(17): 12753-12761, 2024 Sep 06.
Artículo
en Inglés
| MEDLINE
| ID: mdl-39189527
RESUMEN
We disclose a rapid and nontoxic procedure to construct various oxindoles. This method harnesses the power of a catalytic amount of quinone in synergy with Cs2CO3, showcasing remarkable compatibility with a wide range of functional groups. Mechanistic investigations reveal that it operates via a radical pathway, likely initiated by the single-electron transfer from quinone-Cs2CO3 complexes. This pivotal electron transfer event leads to the generation of a crucial alkyl radical intermediate, contributing to the overall success and efficacy of the transformation.