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BACKGROUND: Percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI) with high-grade thrombus is a high-risk intervention associated with poor clinical outcomes. Circulatory support with an intra-aortic balloon pump (IABP) during PCI may potentially improve coronary hemodynamics and clinical outcomes in such patients. As existing data on this situation are sparse, we did an observational study to determine short-term outcomes of PCI with IABP support in STEMI patients with high thrombus burden. OBJECTIVES: To determine whether IABP has a potential role in improving outcomes in patients with STEMI with high thrombus burden who are undergoing PCI. METHODS AND RESULTS: Thirty consecutive patients of STEMI with high thrombus burden undergoing PCI with IABP assistance were included. Ninety-three percent of patients had a cardiogenic shock. Clinical and angiographic outcomes assessed include a change in left ventricular ejection fraction (LVEF), 30-day mortality, and assessment of TIMI (thrombolysis in myocardial infarction) flow, TIMI frame count, and TIMI myocardial perfusion grade in the culprit vessel. IABP was initiated before coronary angiography in 36.6% (n=11), between angiography and PCI in 30% (n=9), and after PCI in 33.3% (n=10) of patients. During the 30-day follow-up period, 50% (n=15) of patients died. 86.6% (n=13) of survivors had pre-PCI IABP initiation compared to only 46.6% (n=7) among those who died (p=0.020). With pre-PCI IABP initiation (n=20), 30-day mortality was 35% (n=7) compared to 80% (n=8) with post-PCI IABP initiation (n=10) (p=0.020). CONCLUSION: IABP initiation before PCI in STEMI complicated by cardiogenic shock and high angiographic thrombus burden can decrease mortality without any effect on angiographic parameters.
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Subacute right ventricular perforation by a pacemaker lead is a rare complication. Although occasionally asymptomatic, complicated cases are usually evidently symptomatic. Here, we report a 70-year-old man presented with mild left-sided chest pain three days after permanent pacemaker implantation. Suspected of ventricular perforation by the pacemaker lead on chest X-ray, device interrogation revealed non-corroborative parameters. This warranted a computed tomography (CT) scan, which confirmed the diagnosis, detected hemopneumothorax, and helped plan surgical intervention. The patient underwent surgical management with the placement of an epicardial pacemaker lead and was discharged after five days. Our case illustrates a rare report of subtle clinical presentation in a patient with subacute right ventricular perforation by a pacemaker lead complicated by hemopneumothorax. It further recapitulates the role of CT scan in providing definitive diagnostic information in managing such a patient. Anticipation of such a presentation is essential for primary care physicians, who are often a first contact point for a patient in the community. This requires a high index of suspicion in such patients presenting with minimal symptoms. Early recognition and timely referral by a family physician may prevent untoward consequences of device-related complications.
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Introduction Chronic heart failure (CHF) is a major cause of mortality and morbidity in spite of tremendous advances in medical therapies. Vitamin D deficiency has been increasingly recognised in heart failure and its therapeutic as well as prognostic implications are debated. This study was carried out to examine the relationship of Vitamin D levels with severity of heart failure as assessed by NYHA functional class and serum N-terminal pro-brain natriuretic peptide (NT-pro-BNP) levels in vitamin D deficient patients with CHF. Methodology and results In this cross-sectional analysis, 119 patients of symptomatic CHF presenting to the outpatient/inpatient department of cardiology in a tertiary care institute in North India were screened. Patients were categorised according to their functional class as New York Heart Association (NYHA) class II, III, IV and their serum levels of vitamin D and NT-pro-BNP were measured. Out of 119 patients, 107 (90%) were found to have low vitamin D levels which were classified as insufficient (20-30 ng/ml) (n=25, 23%) or deficient (<20 ng/ml) (n=82,77%). The mean NT-pro-BNP levels increased significantly across functional class as 3783±6132 pg/ml, 7866±4383 pg/ml, 21115±11905 pg/ml in NYHA class II, III and IV respectively (p=0.000). The respective mean serum Vitamin D3 levels of 11.6±5.8ng/ml, 12.2±7.9 ng/ml, 14.4±8.9 ng/ml were not significantly different between classes (p=0.234). We found no correlation between serum NT-pro-BNP and serum vitamin D levels in the study cohort across various NYHA classes. In multivariate regression model, after adjusting for various co-variates, vitamin D levels were not significantly associated with NT-pro-BNP or functional class in patients with CHF. Conclusion Patients with CHF have a high prevalence (90%) of vitamin D deficiency. Although NT-pro-BNP levels increase significantly, vitamin D levels do not vary significantly with worsening NYHA classes. Further, no consistent significant correlation of vitamin D deficiency with NT-pro-BNP across different NYHA classes was observed. Thus, low levels of vitamin D didn't predict the severity and prognosis of patients with heart failure. .
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Background Variable residual thrombus ranging from minimal to a large thrombus is seen in the culprit vessel after successful thrombolysis in ST-elevation myocardial infarction (STEMI). Factors associated with residual thrombus in thrombolysed patients are poorly understood. The objective of our study was to determine the correlates of residual thrombus burden in successfully thrombolysed STEMI patients receiving dual antiplatelet therapy. Methods In this prospective observational study of 60 successfully thrombolysed STEMI patients receiving dual antiplatelet therapy, various clinical and coronary angiographic features like residual thrombus burden, residual stenosis, and thrombolysis in myocardial infarction (TIMI) flow grade in the infarct-related artery were evaluated. Results Out of 60 patients, 49 and 11 patients, respectively, had low and high thrombus burden. Thirty-seven (75.5%) patients amongst low-grade thrombus had TIMI 3 flow, whereas seven (63.6%) amongst high thrombus burden had TIMI 2 flow indicating an association between residual thrombus burden and TIMI flow grade, which was statistically significant (p=0.009). Further, amongst the 39 patients who were 45 years old, a statistically significant association of age and residual stenosis (p = 0.039) was observed. Conclusion In successfully thrombolysed STEMI patients receiving dual antiplatelet therapy, there is an inverse correlation between residual thrombus burden and TIMI flow grade with high-grade residual thrombus associated with more frequent low TIMI flow. Further, significant residual stenosis is more common in patients older than 45 years of age, underscoring the necessity for invasive evaluation after successful thrombolysis.
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Persistent left superior vena cava (LSVC) can be incidentally detected during pacemaker implantation through left pectoral side. There is technical difficulty of optimal site pacing and lead stability for right ventricle lead in such situation. We hereby report a case of successful single-chamber implantable cardioverter defibrillator (ICD) implantation in a 50 years-old male with LSVC. The practical issues related with right ventricle lead implantation and pacing/defibrillation parameters for ICD device are discussed.
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Percutaneous carotid stenting with a distal-protection device is now considered an alternative to standard carotid endarterectomy. Although distal-protection filter devices have been reported to reduce the risk of embolism and stroke, their use is associated with such iatrogenic complications as vasospasm, dissection, and guidewire entrapment. Herein, we report a case of symptomatic carotid vasospasm caused by a distal-protection filter device during right internal carotid artery intervention in a woman who had underlying coronary artery disease. We also discuss the management of iatrogenic carotid spasm.