RESUMEN
It has been studied how preventive administration of EDTA influences toxic NO2- induced pulmonary edema and disturbances in antioxidant systems. The compound in question, being preventively administered, has exerted a significant antiedematic effect as a result of a decrease in lipid peroxidation intensity and protection of the most important substrate components of the nonenzymatic antioxidant system from the oxidation effect.
Asunto(s)
Antídotos/farmacología , Antioxidantes/metabolismo , Ácido Edético/farmacología , Peroxidación de Lípido/efectos de los fármacos , Dióxido de Nitrógeno/antagonistas & inhibidores , Edema Pulmonar/tratamiento farmacológico , Animales , Ácido Edético/química , Masculino , Ratones , Ratas , Ratas Wistar , Sodio/químicaRESUMEN
Influence of intraperitoneal administration of polygalacturonic acid derivatives at a dose of 100 mg/kg on the glutathione system and lipid peroxidation in the rat lung after treatment with NO2 was studied. A considerable decrease of lipid peroxidation intensity by these derivatives was caused not only by ability of these compounds to the chelate formation and absorption of free radicals, but also by the substantial activation of the glutathione system.