RESUMEN
The review presents the results of clinical-observations of side hepatotoxic effects of drugs from different pharmacological groups. Based on the data available in the literature, the authors systematized and supplemented the characteristic types of hepatic damages due to the use of drugs in different fields of medicine. The basic mechanisms responsible for the damaging effects of hepatotropic pharmacological agents are considered. The review places a particular emphasis on the major hepatic dysfunctions observed in oncological care when antitumor drugs having different mechanisms of action. This section of the review is supplemented with cases observed in the past years, wherein there are data on the hepatotoxicity of agents from the platin group, the nonsteroidal antiandrogen flutamide, topoisomerase II inhibitors in addition to the well-known alkylating drugs and antitumor antibiotics that have hepatotoxic properties.
Asunto(s)
Enfermedad Hepática Inducida por Sustancias y Drogas/etiología , Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos , Hígado/efectos de los fármacos , HumanosRESUMEN
In the experiments on Wistar rats we showed that administration of ulcerogenic drugs (cinchophen, acetylsalicylic acid, butadione, indomethacin etc.) produced the alterations of free activity of lysosomal enzymes in the homogenates of ulcerated stomachs, presumably the significant elevation of the activity of cathepsins (more often cathepsin with optimum of activity at pH 5.5) and the significant reduction of free activity of acid nucleases (more often of DNA-ase). The alterations of free activity of lysosomal enzymes were as in cases with gastric ulcerations as in cases with unaffected stomachs.
Asunto(s)
Catepsinas/análisis , Desoxirribonucleasas/análisis , Lisosomas/enzimología , Ribonucleasas/análisis , Úlcera Gástrica/inducido químicamente , Estómago/enzimología , Animales , Aspirina/efectos adversos , Indometacina/efectos adversos , Masculino , Fenilbutazona/efectos adversos , Quinolinas/efectos adversos , Ratas , Ratas Endogámicas , Estómago/efectos de los fármacos , Úlcera Gástrica/enzimologíaRESUMEN
Distribution of sulfalen, sulfadimethoxine and sulfamethoxypyridazine in the blood and organs of rats and binding of the drugs to the blood serum proteins of the animals with experimental P. aeruginosa pyelonephritis were studied. It was shown that in rats with P. aeruginosa pyelonephritis the levels of long-acting sulfanilamides in the blood and organs were lower, while the levels of their penetration through the histohematic barriers were higher, which was partially due to the decreased binding of sulfanilamides to blood proteins.