RESUMEN
This study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case-control study was carried out and 30 young obese non-diabetic (23.90 ± 3.84 years and BMI 37.92 ± 4.85 kg/m2) and 28 age-matched healthy lean (24.56 ± 3.50 years and BMI of 22.10 ± 1.72 kg/m2) men were included in this study. The primary outcome measures were serum basal ANGPTL3 and ANGPTL3-area under the curve (AUC) levels. The percentage of body fat was measured by dual-energy X-ray absorptiometry and biochemical, hormonal and insulin resistance indices were determined. Basal ANGPTL3 and ANGPTL3-AUC levels were significantly elevated (p < 0.05) in young obese subjects compared with lean subjects and were positively and significantly associated with different anthropometric measurements. Fasting ANGPTL3 serum levels were positively correlated with fasting insulin, leptin, Leptin/Adiponectin index and triglyceride-glucose index. Moreover, ANGPTL3-AUC was negatively correlated with Matsuda index. In this regard, chronically high ANGPTL3 levels in young obese subjects might favor triglyceride-rich lipoprotein clearance to replenish triglyceride stores by white adipose tissue rather than oxidative tissues.
Asunto(s)
Proteínas Similares a la Angiopoyetina/sangre , Diabetes Mellitus/sangre , Obesidad/sangre , Proteína 3 Similar a la Angiopoyetina , Glucemia/metabolismo , Ayuno/sangre , Prueba de Tolerancia a la Glucosa , Humanos , Insulina/sangre , Resistencia a la Insulina , Masculino , Obesidad/complicaciones , Adulto JovenRESUMEN
Resumen Introducción: La llegada en periodo de ventana terapéutica de un paciente con ictus isquémico al hospital depende de la identificación de las manifestaciones clínicas y el reconocimiento de que se trata de una urgencia médica. Métodos: Se realizó un estudio prospectivo, longitudinal, de corte transversal para el cual se diseñó una entrevista estructurada con preguntas cerradas. Objetivo. Evaluar el grado de conocimiento de la población acerca del infarto cerebral. Resultados: Se entrevistaron 135 sujetos sin diagnóstico de ictus, seleccionados al azar entre los familiares de pacientes. La edad media de fue de 42,6 años, predominaron las mujeres (92/68,1%) y el grado de instrucción medio. El 95,5% (129 sujetos) admitió tener poco conocimiento sobre el ictus. Solo el 11,1% señaló de forma correcta las manifestaciones clínicas; el síntoma más reconocido fue el amortiguamiento (59,3%) seguido de los trastornos del habla. El 80,9% identifican el ictus como una condición prevenible. Menos de la mitad de los participantes nombraron adecuadamente los factores de riesgo (66/48,9%). El 88,2% toma una actitud correcta ante los síntomas. Conclusiones: En el grupo de personas entrevistadas el conocimiento acerca de las manifestaciones y los factores de riesgo vascular es deficiente. Es necesario realizar campañas informativas dirigidas a mejorar el conocimiento de la enfermedad.
Summary Introduction: The arrival of patients with ischemic stroke to the hospital in the period of the therapeutic window, depends to a great extent on the identification of their clinical signs and the recognition that it is a medical emergency. Methods: A prospective, longitudinal, cross-sectional study was carried out, based on a structured interview with closed questions. The aim was to access the degree of the population's knowledge about the ischemic stroke. Results: A total of 135 subjects without a diagnosis of stroke were interviewed, randomly selected from the relatives of patients. The average age was 42.6 years, women predominated (92 / 68.1%), with an average level of education. 95.5% (129 subjects) admitted having little knowledge about stroke. Only 11.1% correctly indicated the clinical manifestations; The most recognized symptom was damping (59.3%) followed by speech disorders. 80.9% (109 respondents) identify stroke as a preventable condition. Less than half of the participants adequately named the risk factors (66 / 48.9%). 88.2% take a correct attitude to the symptoms. Conclusions: In the group of people interviewed there is a perception of risk regarding stroke, but knowledge about the manifestations and vascular risk factors is poor. It is necessary to carry out information campaigns aimed to improve knowledge of the disease.
RESUMEN
La necrólisis epidérmica tóxica es una patología de escasa ocurrencia, que se acompaña de mortalidad elevada y se caracteriza por lesiones cutáneas vesículo ampollosas que con frecuencia afecta la mucosa respiratoria, digestiva y ocular. Se presenta un caso de la enfermedad atendido en el Hospital Universitario de Santander en octubre del año 2007 desencadenado por el tratamiento con fenitoína ácido valproico como terapia anticonvulsiva, con desenlace fatal y al cual se le practicó autopsia médico científica. Se pretende con este trabajo presentar una revisión del tema y analizar los factores relacionados con esta grave condición clínica...
Toxic epidermal necrolysis is an infrequent pathology, accompanied of high mortality risk in concordance with extension of comprised skin characterized for blisters. Frequently these are present in respiratory, digestive and ocular mucous. An autopsy case is presented occurred in Hospital Universitario de Santander in October 2007 of toxic epidermal necrolysis secondary to treatment with phenytoin associated with valproic acid as anticonvulsivant therapy for messial hippocampal sclerosis. It pretends with this work show a review and to analyze related factors with this condition...