RESUMEN
BACKGROUND AND PURPOSE: To compare in a phase III study the loco-regional control, disease-free survival and overall survival induced by an accelerated regimen (AF) as compared with conventional regimen (CF) and to analyze the early and late post-radiation morbidity in both arms. MATERIALS AND METHODS: Patients with age < or = 75, WHO 0-1, suitable for a radical course of radiotherapy T1-T3, N0, M0, stage of glottic and supraglottic laryngeal cancer were randomized to either CF: 66Gy given in 33 fractions over 45 days or AF: 66Gy given in 33 fractions over 38 days (2 fractions every Thursday). A total of 395 patients were included from 05.1995 to 12.1998. RESULTS: Early toxicity: At the end of radiotherapy patients treated with AF complained for more severe reactions than patients treated with CF. In 8 weeks after treatment completion patients treated with AF complained only for more severe pain on swallowing (P=0.027). In 4 months after treatment completion all types of toxicity except for skin teleangiectasia (P=0.001) were similar in the two groups. Loco-regional control: comparison between CF and AF showed no difference in terms of loco-regional control (P=0.37). CONCLUSIONS: The improvement in AF in terms of loco-regional control is estimated to be 3-5% in comparison with conventional regimen and is not significant. The intensity of reactions after 4 months was similar in both arms, what suggests the possibility of further shortening of the overall time by few days or enhancing the total dose within the limits of acceptable morbidity.
Asunto(s)
Carcinoma de Células Escamosas/radioterapia , Neoplasias Laríngeas/radioterapia , Anciano , Carcinoma de Células Escamosas/mortalidad , Carcinoma de Células Escamosas/patología , Femenino , Humanos , Neoplasias Laríngeas/mortalidad , Neoplasias Laríngeas/patología , Masculino , Terapia Recuperativa , Tasa de Supervivencia , Resultado del TratamientoRESUMEN
A method of measuring a decrease in the respiration rate as an index of chemical substances irritating effects upon mice's upper respiratory tract has been checked and adopted. A dose of irritating substances resulting in the respiration rate decrease by 50%--RD50 has been determined, as related to exposure to chlorine, ammonia and acrolein. The RD50 values for chlorine and acrolein approximated those quoted by Alarie Y., whereas for ammonia exposure this value differed.
Asunto(s)
Acroleína/efectos adversos , Contaminantes Atmosféricos/efectos adversos , Aldehídos/efectos adversos , Amoníaco/efectos adversos , Cloro/efectos adversos , Respiración/efectos de los fármacos , Animales , Irritantes , Concentración Máxima Admisible , Ratones , Ratones Endogámicos BALB CAsunto(s)
Antineoplásicos/administración & dosificación , Protocolos de Quimioterapia Combinada Antineoplásica , Linfoma/tratamiento farmacológico , Bleomicina/administración & dosificación , Ciclofosfamida/administración & dosificación , Doxorrubicina/administración & dosificación , Esquema de Medicación , Quimioterapia Combinada , Femenino , Humanos , Masculino , Metotrexato/administración & dosificación , Regresión Neoplásica Espontánea , Prednisona/administración & dosificación , Procarbazina/administración & dosificación , Vincristina/administración & dosificaciónAsunto(s)
Antineoplásicos/efectos adversos , Plaquetas/efectos de los fármacos , Enfermedad de Hodgkin/tratamiento farmacológico , Leucocitos/efectos de los fármacos , Esplenectomía , Adolescente , Adulto , Anciano , Femenino , Humanos , Recuento de Leucocitos , Leucopenia/epidemiología , Masculino , Persona de Mediana Edad , Recuento de PlaquetasRESUMEN
Experiments were carried out on female rabbits with electrodes implanted chronically into the midbrain, dorsal hippocampus and the cerebral cortex. Physiological impedance of the brain stem, i.e. the lowest energy of trains of electric impulses stimulating the midbrain modulated through a feedback by the hippocampal theta rhythm and maintaining EEG arousal pattern, served as a measure of excitability of the brain stem reticular formation. After ovariectomy performed in 12 female rabbits, a rise in the brain stem physiological impedance was observed in relation to control measurements -- by 84.8%, on the average. In 8 ovariectomized female rabbits the physiological impedance decreased by 47.4% after subcutaneous implantation of oestradiol benzoate tablets. After removal of the implanted tablets the impedance increased by a mean value of 100.1% in all the female rabbits.