RESUMEN
We report cases of spotted fever rickettsiosis in Coronel Fabriciano Municipality of Minas Gerais State, Brazil. The cases occurred in May and June of 2000. During this period there were two deaths among children from an area named Pedreira in a periurban area of this municipality. In a boy who died with clinical manifestations of Brazilian spotted fever, a necropsy revealed the presence of a spotted fever group Rickettsia. The serological results confirm the difficulty in the differential diagnosis of patients with symptoms of rickettsial diseases.
Asunto(s)
Fiebre Maculosa de las Montañas Rocosas/diagnóstico , Adolescente , Animales , Anticuerpos Antibacterianos/sangre , Brasil , Niño , ADN Bacteriano/análisis , Resultado Fatal , Técnica del Anticuerpo Fluorescente Indirecta , Humanos , Inmunoglobulina M/sangre , Masculino , Reacción en Cadena de la Polimerasa , Rickettsia rickettsii/genética , Rickettsia rickettsii/inmunologíaRESUMEN
We report cases of spotted fever rickettsiosis in Coronel Fabriciano Municipality of Minas Gerais State, Brazil. The cases occurred in May and June of 2000. During this period there were two deaths among children from an area named Pedreira in a periurban area of this municipality. In a boy who died with clinical manifestations of Brazilian spotted fever, a necropsy revealed the presence of a spotted fever group Rickettsia. The serological results confirm the difficulty in the differential diagnosis of patients with symptoms of rickettsial diseases
Asunto(s)
Humanos , Masculino , Niño , Fiebre Maculosa de las Montañas Rocosas , Anticuerpos Antibacterianos , Brasil , ADN Bacteriano , Resultado Fatal , Técnica del Anticuerpo Fluorescente Indirecta , Reacción en Cadena de la Polimerasa , Rickettsia rickettsiiRESUMEN
The emergence and reemergence of a serious infectious disease are often associated with a high case-fatality rate because of misdiagnosis and inappropriate or delayed treatment. The current reemergence of spotted fever rickettsiosis caused by Rickettsia rickettsii in Brazil has resulted in a high proportion of fatal cases. We describe two familial clusters of Brazilian spotted fever in the state of Minas Gerais, involving six children 9 months to 15 years of age; five died. Immunohistochemical investigation of tissues obtained at necropsy of a child in each location, Novo Cruzeiro and Coronel Fabriciano municipalities, established the diagnosis by demonstration of disseminated endothelial infection with spotted fever group rickettsiae. The diagnosis in the two fatal cases from Coronel Fabriciano and the surviving patient from Novo Cruzeiro was further supported by immunofluorescence serologic tests.