RESUMEN

The antioxidant activity of butane-type lignans was evaluated. Secoisolariciresinol (SECO) and dihydroguaiaretic acid (DGA) showed higher radical scavenging activity than that of 7,7'-dioxodihydroguaiaretic acid (ODGA). SECO and DGA inhibited the oxidation of unsaturated fatty acid. Both enantiomers of DGA were also lipoxygenase inhibitors, but neither enantiomer of SECO inhibited the lipoxygenase activity.

Asunto(s)

Butanos/química , Butileno Glicoles/farmacología , Depuradores de Radicales Libres/farmacología , Guayacol/análogos & derivados , Lignanos/farmacología , Butileno Glicoles/química , Depuradores de Radicales Libres/química , Guayacol/química , Guayacol/farmacología , Lignanos/química , Inhibidores de la Lipooxigenasa/química , Inhibidores de la Lipooxigenasa/farmacología , Oxidación-Reducción , Estereoisomerismo