RESUMEN

Polyamines with diamine structures of chain length longer than 3C were essential for the synthesis of phosphatidic acid (PA) from ricinoleoyl-CoA and lysophosphatidic acid (LPA) by the castor LPA acyltransferase reaction, suggesting that polyamines modulate enzyme affinity for the acyl-CoA substrate in vivo.

Asunto(s)

Aceite de Ricino/biosíntesis , Lisofosfolípidos/metabolismo , Poliaminas/farmacología , Acilcoenzima A/metabolismo , Acilación/efectos de los fármacos , Ácidos Fosfatidicos/biosíntesis , Ácidos Ricinoleicos/metabolismo