RESUMEN
Three new labdane diterpenoids, pacovatinins A-C (1-3), were isolated from seeds of the Brazilian medicinal plant Renealmia exaltata ("Pacová-catinga"), and their structures including absolute configurations were elucidated by spectroscopic data and a modified Mosher method.
Asunto(s)
Antineoplásicos Fitogénicos/aislamiento & purificación , Diterpenos/aislamiento & purificación , Plantas Medicinales/química , Animales , Antineoplásicos Fitogénicos/química , Antineoplásicos Fitogénicos/farmacología , Brasil , Carcinoma de Células Escamosas , Diterpenos/química , Diterpenos/farmacología , Humanos , Leucemia L1210 , Espectroscopía de Resonancia Magnética/métodos , Ratones , Conformación Molecular , Estructura Molecular , Semillas/química , Estereoisomerismo , Relación Estructura-Actividad , Células Tumorales Cultivadas/efectos de los fármacosRESUMEN
Acutifolin A (1), a novel constituent with a bicyclo[3.3.1]non-3-ene-2,9-dione ring, acutifolins B-F (2-6), five new flavans, and three known flavans were isolated from the bark of Brosimum acutifolium, a Brazilian folk medicine ("Mururé"). Their structures were elucidated by spectroscopic methods, including 2D NMR.
Asunto(s)
Antiinflamatorios no Esteroideos/aislamiento & purificación , Flavonoides/aislamiento & purificación , Moraceae/química , Plantas Medicinales/química , Antiinflamatorios no Esteroideos/química , Brasil , Flavonoides/química , Medicina Tradicional , Conformación Molecular , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Corteza de la Planta/química , Espectrofotometría Infrarroja , Relación Estructura-ActividadRESUMEN
A selective potent anti-Helicobacter pylori isoflavone was isolated from a Brazilian Medicinal Plant, Myroxylon peruiferum. The isolation bioassay-guided and the characterization of an active anti-H. pylori constituent was performed using the methanol extract of plant of minute amount. The active compound was identified as cabreuvin (1), an isoflavone derivative. The structure-activity relationships of several related compounds were also investigated.