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Reverse zoonosis reveals the process of transmission of a pathogen through the human-animal interface and the spillback of the zoonotic pathogen. In this article, we methodically demonstrate various aspects of reverse zoonosis, with a comprehensive discussion of SARS-CoV-2 and MPXV reverse zoonosis. First, different components of reverse zoonosis, such as humans, different pathogens, and numerous animals (poultry, livestock, pets, wild animals, and zoo animals), have been demonstrated. Second, it explains the present status of reverse zoonosis with different pathogens during previous occurrences of various outbreaks, epidemics, and pandemics. Here, we present 25 examples from literature. Third, using several examples, we comprehensively illustrate the present status of the reverse zoonosis of SARS-CoV-2 and MPXV. Here, we have provided 17 examples of SARS-CoV-2 reverse zoonosis and two examples of MPXV reverse zoonosis. Fourth, we have described two significant aspects of reverse zoonosis: understanding the fundamental aspects of spillback and awareness. These two aspects are required to prevent reverse zoonosis from the current infection with two significant viruses. Finally, the One Health approach was discussed vividly, where we urge scientists from different areas to work collaboratively to solve the issue of reverse zoonosis.

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The largest, longest, and deadliest ever-recorded outbreak of Ebola virus disease in human history occurred in West Africa from December 2013 to March 2016 causing 28,652 infections resulting in 11,325 deaths in 10 countries with 99% of the fatality occurred in neighboring Guinea, Sierra Leone, and Liberia. This was the first time the virus outbreak occurred outside its niche in East and Central Africa. This study identified some of the factors that complicated the outbreak, which include delay in the identification of the pathogen, weak health systems, unavailability of licensed drugs or vaccines for the disease, delay in global responses, and cultural practices. Responses were mostly limited to testing, barrier nursing, and treatment of complications. Experimental drugs and vaccines were deployed on compassionate grounds, few have been further developed, trialed, and licensed. It is therefore expected that the current outbreak of Ebola virus disease in Guinea will be better managed.

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Africa is becoming known for the emergence and re-emergence of Ebola virus. The virus, which was initially restricted to East and Central Africa, is now emerging in West Africa. Ecological aspects of Ebola virus diseases are poorly understood. It is suspected that the virus is circulating in the forests of Africa, mostly hosted by migratory bats, which spread the virus to other wildlife particularly great apes and duikers. Spillovers occur when humans have contacts with wildlife. Transmission of the virus within human systems occurs through contacts with body fluids of an infected person. Several factors seem to be responsible for the emergence and re-emergence of the virus in Africa including circulation of the virus in forest ecosystems, persistence of the virus in body fluids (during sickness, upon death, and in survivors), transmission through diverse routes (direct contacts, fomites, oral), presence of infected migratory bats and other wildlife species, forest encroachment, and climatic and seasonal changes. Recent studies show that fresh outbreaks can emerge not only from wildlife but also from survivors of previous outbreaks. It is therefore important to understand the ecology of the virus in order to mitigate future emergence.

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Canalization carried out during petroleum exploration is contributing to environmental changes in the Niger Delta. We carried out a study on five decades of canalization in Olero Creek, Benin River, from 1980 to 2020. The study site covered an area of 36.40 km2. Satellite imageries of five epochs (1980, 1990, 2000, 2010, and 2020) and Shuttle Radar Topographic Mission (SRTM) of 2000, which provided digital elevation models (DEMs) of the study area were collected and analyzed using ERDAS IMAGINE 9.2 and ArcGIS 10.6 software. We found that the total length of dredged canal increased from 14.14 km in 1980 to 61.07 km in 2020, spoil banks doubled from 2.05 km2 in 1980 to 4.13 km2 in 2020, and direct wetland loss doubled from 3.76 km2 in 1980 to 7.57 km2 in 2020, with the largest increase occurring between 1990 and 2000. The land use/land cover, topography, and hydrology of the area also changed. Water bodies that originally accounted for 1.17% of the study area in 1980, increased to 22% in 2020, Rhizophora racemosa fringing the waterbodies increased from 11% in 1980 to 47% in 2020, and Rhizophora mangle decreased from over 55% in 1980 to about 23% in 2020. The results of digital elevation model show that the surface area is undulating with the relative topography of the study site ranging from - 5 to 40 m. We conclude that canalization during petroleum exploration was contributing to land use, topographic, and hydrologic changes in the study area.

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Cassava is majorly processed into gari by smallholders in Southern Nigeria. During processing, large volume of effluents are produced in the pressing stage of cassava tuber processing. The cassava mill effluents are discharged into the soil directly and it drain into nearby pits, surface water, and canals without treatment. Cassava mill effluents is known to alter the receiving soil and water characteristics and affects the biota in such environments, such as fishes (water), domestic animals, and vegetation (soil). This study investigated the potential of Saccharomyces cerevisiae to be used for the treatment of some physicochemical properties of cassava mill effluents. S. cerevisiae was isolated from palm wine and identified based on conventional microbiological techniques, viz. morphological, cultural, and physiological/biochemical characteristics. The S. cerevisiae was inoculated into sterile cassava mill effluents and incubated for 15 days. Triplicate samples were withdrawn from the setup after the fifth day of treatment. Portable equipment was used to analyze the in-situ parameters, viz. total dissolved solids (TDS), pH, dissolved oxygen (DO), conductivity, salinity, and turbidity. Anions (nitrate, sulphate, and phosphate) and chemical oxygen demand (COD) were analyzed using spectrophotometric and open reflux methods respectively. Results showed a decline of 37.62%, 22.96%, 29.63%, 20.49%, 21.44%, 1.70%, 53.48%, 68.00%, 100%, and 74.48% in pH, conductivity, DO, TDS, salinity, sulphate, nitrate, phosphate, and COD levels respectively, and elevation of 17.17% by turbidity. The study showed that S. cerevisiae could be used for the treatment of cassava mill effluents prior to being discharged into the environment so as to reduce the pollution or contamination and toxicity levels.

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Incidence of methanol contamination of traditionally fermented beverages is increasing globally resulting in the death of several persons. The source of methanol contamination has not been clearly established in most countries. While there were speculations that unscrupulous vendors might have deliberately spiked the beverages with methanol, it is more likely that the methanol might have been produced by contaminating microbes during traditional ethanol fermentation, which is often inoculated spontaneously by mixed microbes, with a potential to produce mixed alcohols. Methanol production in traditionally fermented beverages can be linked to the activities of pectinase producing yeast, fungi and bacteria. This study assessed some traditional fermented beverages and found that some beverages are prone to methanol contamination including cachaca, cholai, agave, arak, plum and grape wines. Possible microbial role in the production of methanol and other volatile congeners in these fermented beverages were discussed. The study concluded by suggesting that contaminated alcoholic beverages be converted for fuel use rather than out rightly banning the age-long traditional alcohol fermentation.

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Ebola virus is one of the most dangerous microorganisms in the world causing hemorrhagic fevers in humans and non-human primates. Ebola virus (EBOV) is a zoonotic infection, which emerges and re-emerges in human populations. The 2014 outbreak was caused by the Zaire strain, which has a kill rate of up to 90%, though 40% was recorded in the current outbreak. The 2014 outbreak is larger than all 20 outbreaks that have occurred since 1976, when the virus was first discovered. It is the first time that the virus was sustained in urban centers and spread beyond Africa into Europe and USA. Thus far, over 22,000 cases have been reported with about 50% mortality in one year. There are currently no approved therapeutics and preventive vaccines against Ebola virus disease (EVD). Responding to the devastating effe1cts of the 2014 outbreak and the potential risk of global spread, has spurred research for the development of therapeutics and vaccines. This review is therefore aimed at presenting the progress of vaccine development. Results showed that conventional inactivated vaccines produced from EBOV by heat, formalin or gamma irradiation appear to be ineffective. However, novel vaccines production techniques have emerged leading to the production of candidate vaccines that have been demonstrated to be effective in preclinical trials using small animal and non-human primates (NHP) models. Some of the promising vaccines have undergone phase 1 clinical trials, which demonstrated their safety and immunogenicity. Many of the candidate vaccines are vector based such as Vesicular Stomatitis Virus (VSV), Rabies Virus (RABV), Adenovirus (Ad), Modified Vaccinia Ankara (MVA), Cytomegalovirus (CMV), human parainfluenza virus type 3 (HPIV3) and Venezuelan Equine Encephalitis Virus (VEEV). Other platforms include virus like particle (VLP), DNA and subunit vaccines.

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