RESUMEN

The presence of human immunodeficiency virus (HIV) in genital secretions is regarded as a risk factor for sexual and perinatal transmission of HIV. A better understanding of correlates of genital shedding of HIV is crucial to the development of effective strategies against transmission of this virus. Events during menstrual cycle are likely to influence local immune responses and viral load in genital secretions, and hence determine susceptibility to HIV or efficiency of virus transmission. We report, in this study, preliminary findings on the relationship of menstrual cycle to genital mucosal and systemic immunity in female olive baboons (Papio anubis) experimentally inoculated with simian/human immunodeficiency virus (SHIV)89.6P.

Asunto(s)

Genitales Femeninos/inmunología , VIH/inmunología , Inmunidad Mucosa , Ciclo Menstrual/fisiología , Papio/fisiología , Papio/virología , Virus de la Inmunodeficiencia de los Simios/inmunología , Animales , Anticuerpos Antivirales/análisis , Anticuerpos Antivirales/sangre , Cuello del Útero/inmunología , Estradiol/sangre , Femenino , Anticuerpos Anti-VIH/análisis , Anticuerpos Anti-VIH/sangre , Papio/inmunología , Progesterona/sangre , Vagina/inmunología