RESUMEN
Intraperitoneal injection of cadmium chloride (4 mg/kg) to rats before elaboration or reproduction of two-way avoidance conditioned reflex (TACR) disturbs both these processes. Deterioration of elaboration does not affect connections fixation and their subsequent reproduction. Injection of the substance before the elaboration of passive avoidance conditioned reflex (PACR) depresses elaboration and consolidation. Injection of cadmium chloride before testing of PACR preservation does not influence the processes of engrams reproduction. The observed disturbances cannot be connected with changes of animals motor activity.
Asunto(s)
Reacción de Prevención/efectos de los fármacos , Cadmio/farmacología , Memoria/efectos de los fármacos , Animales , Cloruro de Cadmio , Condicionamiento Clásico/efectos de los fármacos , Estimulación Eléctrica , Masculino , Actividad Motora/efectos de los fármacos , Estimulación Luminosa , Ratas , Factores de TiempoRESUMEN
Pretreatment with 20 mg/kg nicotinamide 3 days prior to a single intraperitoneal 6 mg/kg adriblastin injection, followed by repeated injections every second days for 1 week, prevented cardiac contractility disorders in adriblastin-treated rats, while their cardiac contractility was less prone to hypoxic depression and recovered better at subsequent reoxygenation.
Asunto(s)
Cardiomiopatías/tratamiento farmacológico , Doxorrubicina/efectos adversos , Insuficiencia Cardíaca/prevención & control , Hipoxia/tratamiento farmacológico , Contracción Miocárdica/efectos de los fármacos , Niacinamida/uso terapéutico , Animales , Cardiomiopatías/inducido químicamente , Insuficiencia Cardíaca/etiología , Hipoxia/inducido químicamente , RatasRESUMEN
The contractility of the myocardium in isovolume regimen of the heart activity was characterized by a considerably lower level of relaxation in the August line rats than in nonspecific rats. The coronary flow was found to be significantly reduced in the August and VAG line rats. The sensitivity to hypoxia was higher in the August line rats than in nonspecific ones. The VAG line rats were less resistant against the following reoxygenation.
Asunto(s)
Contracción Miocárdica , Oxígeno/fisiología , Animales , Técnicas In Vitro , Ratas , Ratas Endogámicas , Especificidad de la EspecieAsunto(s)
Hidroxitolueno Butilado/uso terapéutico , Cardiomiopatías/metabolismo , ADN/efectos de los fármacos , Doxorrubicina/toxicidad , Corazón/efectos de los fármacos , Peróxidos Lipídicos/metabolismo , Miocardio/metabolismo , Animales , Cardiomiopatías/inducido químicamente , Cardiomiopatías/prevención & control , ADN/biosíntesis , Evaluación Preclínica de Medicamentos , Radicales Libres , Oxidación-Reducción/efectos de los fármacos , Ratas , Timidina/metabolismo , Factores de TiempoRESUMEN
Injections to rats of antibiotic adriblastin activating lipids peroxide oxidation directly after elaboration of defensive conditioned reflexes, elicit retrograde amnesia. Administration of antioxidant ional before the administration of adriblastin prevents this effect. It is suggested that activation of lipids peroxide oxidation disturbs the process of consolidation.
Asunto(s)
Antioxidantes/uso terapéutico , Encefalopatías/inducido químicamente , Doxorrubicina/toxicidad , Peróxidos Lipídicos/biosíntesis , Trastornos de la Memoria/inducido químicamente , Animales , Reacción de Prevención/efectos de los fármacos , Encéfalo/metabolismo , Condicionamiento Clásico/efectos de los fármacos , Doxorrubicina/antagonistas & inhibidores , Masculino , Trastornos de la Memoria/prevención & control , Ratas , Retención en Psicología/efectos de los fármacosRESUMEN
Both single and graded administration of an anthracycline antibiotic adriablastine at a dose of 20 mg/kg to white rats have resulted in cardiomyocyte volume decrease, dystrophia and lysis of myofibrils, and reduction of mitochondrial surface density volume. Accumulations of myelin bodies of different configuration and diffuse myolysis were observed. Myelin bodies and diffuse myolysis of cardiomyocytes in adriablastine-induced cardiomyopathy are believed to be a morphological sign of lipid peroxidation.
Asunto(s)
Cardiomiopatías/inducido químicamente , Doxorrubicina/toxicidad , Corazón/efectos de los fármacos , Miocardio/ultraestructura , Animales , Cardiomiopatías/patología , Doxorrubicina/administración & dosificación , Inyecciones Intraperitoneales , Masculino , Métodos , RatasRESUMEN
Adriblastin was shown to activate considerably lipid peroxidation processes in the heart muscle, mostly through the suppression of antioxidant enzyme (superoxidedysmutase and catalase) activity, with myocardial contractility declining essentially as a result. Pretreatment with the synthetic antioxidant ionol prevented the adriblastin-induced depression of myocardial contractility.