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The establishment of anthropometric measurements is of fundamental importance for the correct identification of human bodies. The objective of this study was to evaluate the accuracy and reliability of two-dimensional craniometric landmarks obtained from three-dimensional cone beam computed tomography reconstructions for forensic identification of humans. Computed tomography images with voxel sizes of 0.25, 0.3, and 0.4 mm were obtained using i-CAT® three-dimensional equipment. Ten landmarks were randomly selected, and 10 measurements were demarcated in the three-dimensional reconstruction to evaluate the mandibular condyle, ramus, and body. This study demonstrated that protocols with voxels of 0.3 mm should be preferentially indicated for the evaluation of linear and angular measurements. Implementing our methodology using prototypes for clinical and forensic simulations allows comparisons with human databases in identification issues.
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The quinolinic ring, present in several molecules, possesses a great diversity of biological activities. Therefore, this ring is in the structural composition of several candidates of drugs in preclinical and clinical studies; thus, it is necessary to compile these results to facilitate the design of new drugs. For this reason, some of the activities of compounds are selected to examine in this review, such as antimalarial, antimicrobial, anticancer, anti-inflammatory, antidiabetic, anti-rheumatic, and antiviral activities. All publications of scientific articles chosen are dated between 2000 and 2020. In addition to presenting the structures of some natural and synthetic compounds with their activities, we have listed the clinical studies of phases III and IV on antimalarial drugs containing the quinoline nucleus and phase III clinical studies on hydroxychloroquine and chloroquine to assess their possible role in COVID-19. Finally, we have reviewed some of the mechanisms of action, as well as the side effects of some of the quinolinic derivatives.
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Antimaláricos , Tratamiento Farmacológico de COVID-19 , Quinolinas , Antimaláricos/farmacología , Antimaláricos/uso terapéutico , Cloroquina/farmacología , Humanos , Hidroxicloroquina/uso terapéuticoRESUMEN
Objective To describe a new presentation of tears and retears of the rotator cuff, which we denominate captured rotator cuff (CRC). We also aim to evaluate it clinically and through images. Methods We assessed retrospectively 16 patients with intraoperative diagnosis of CRC between March 2005 and September 2017; by means of imaging (radiography and magnetic resonance imaging [MRI]) and functional scores (UCLA and Constant & Murley). In images we analyzed the evolution for rotator cuff arthropathy and presence of retears. Functionally, we compared the affected side with the contralateral side and extensive lesions with nonextensive. Results Five (31.25%) patients presented with rotator cuff arthropathy, and 10 (62.5%) with retears. Three (75%) patients with nonextensive lesions had good/excellent UCLA and Constant & Murley scores. In patients with extensive lesions, when the Constant & Murley score was evaluated, 6 (50%) presented good/excellent results, and in the UCLA score, 7 (58.3%). Comparing the affected side (Constant 74.72 points; UCLA 20 points) with the contralateral side (Constant 96.96 points; UCLA 25.63 points), there were worse functional results with statistical significance. Conclusion The diagnosis of CRC is suspected by characteristic findings on MRI and confirmed in arthroscopy. The affected shoulders present worse functional postoperative scores.
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Abstract Objective To describe a new presentation of tears and retears of the rotator cuff, which we denominate captured rotator cuff (CRC). We also aim to evaluate it clinically and through images. Methods We assessed retrospectively 16 patients with intraoperative diagnosis of CRC between March 2005 and September 2017; by means of imaging (radiography and magnetic resonance imaging [MRI]) and functional scores (UCLA and Constant & Murley). In images we analyzed the evolution for rotator cuff arthropathy and presence of retears. Functionally, we compared the affected side with the contralateral side and extensive lesions with nonextensive. Results Five (31.25%) patients presented with rotator cuff arthropathy, and 10 (62.5%) with retears. Three (75%) patients with nonextensive lesions had good/excellent UCLA and Constant & Murley scores. In patients with extensive lesions, when the Constant & Murley score was evaluated, 6 (50%) presented good/excellent results, and in the UCLA score, 7 (58.3%). Comparing the affected side (Constant 74.72 points; UCLA 20 points) with the contralateral side (Constant 96.96 points; UCLA 25.63 points), there were worse functional results with statistical significance. Conclusion The diagnosis of CRC is suspected by characteristic findings on MRI and confirmed in arthroscopy. The affected shoulders present worse functional postoperative scores.
Resumo Objetivo Descrever uma nova apresentação de ruptura e rerruptura do manguito rotador (MR), a qual denominamos manguito capturado (MC). Objetivamos também avaliá-la clinicamente e por meio de imagens. Métodos Foram avaliados retrospectivamente 16 pacientes com diagnóstico intraoperatório de MC no período de março de 2005 a setembro de 2017; por meio de exames de imagem (radiografia e ressonância magnética [RM]) e escores funcionais (UCLA e Constant & Murley). Nas imagens, analisamos a evolução para artropatia do manguito rotador e presença de rerrupturas. Funcionalmente, comparamos o lado afetado com o contralateral e as lesões extensas com nãoextensas. Resultados Cinco (31,25%) pacientes evoluíram com artropatia do manguito rotador e 10 (62,5%) tiveram rerrupturas. Três (75%) pacientes com lesões não extensas tiveram UCLA e Constant & Murley bons/excelentes. Nos pacientes com lesões extensas, quando avaliado Constant & Murley, 6 (50%) apresentaram resultados bons/excelentes, e no escore UCLA, 7 (58,3%). Comparando o lado acometido (Constant 74,72 pontos; UCLA 20 pontos) com o contralateral (Constant 96,96 pontos; UCLA 25,63 pontos), houve pior resultado funcional com significância estatística. Conclusão O diagnóstico de MC é suspeitado por achados característicos na RM e confirmado na artroscopia. Os ombros acometidos apresentam piores escores funcionais pós-operatórios.
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Pronóstico , Rotura , Hombro , Espectroscopía de Resonancia Magnética , Manguito de los Rotadores , Síndrome de Abducción Dolorosa del Hombro , ArtropatíasRESUMEN
BACKGROUND: The etiology of inflammatory bowel disease (IBD) is unknown, but it is believed to be multifactorial. The hygiene hypothesis proposes that better hygiene conditions would lead to less infectious disease during childhood and favor the development of immune-mediated diseases. AIM: To test the hygiene hypothesis in IBD by assessing the environmental risk factors associated with IBD development in different regions of Brazil with diverse socioeconomic development indices. METHODS: A multicenter case-control study was carried out with 548 Crohn's disease (CD) and 492 ulcerative colitis (UC) outpatients and 416 healthy controls, from six IBD centers within different Brazilian states at diverse socioeconomic development stages. A semi-structured questionnaire with 87 socioeconomic and environmental questions was applied. Logistic regression model was created to assess the odds ratio (OR) with P value and 95% confidence intervals (CI). RESULTS: Predictive variables for both diseases (CD and UC) were women [odd ratios (OR) = 1.31; OR = 1.69], low monthly family income (OR = 1.78; OR = 1.57), lower number of cohabitants (OR = 1.70; OR = 1.60), absence of vaccination (OR = 3.11; OR = 2.51), previous history of bowel infections (OR = 1.78; OR = 1.49), and family history of IBD (OR = 5.26; OR = 3.33). Associated risk factors for CD were age (18-39 years) (OR = 1.73), higher educational level (OR = 2.22), absence of infectious childhood diseases (OR = 1.99). The UC predictive variables were living in an urban area (OR = 1.62), inadequate living conditions (OR = 1.48) and former smokers (OR = 3.36). Appendectomy was a risk factor for CD (OR = 1.58) with inverse association with UC (OR = 4.79). Consumption of treated and untreated water was associated with risk of CD (OR = 1.38) and UC (OR = 1.53), respectively. CONCLUSION: This is the first examining environmental exposures as risk factors for inflammatory bowel disease in Brazil. Most of the variables associated with disease risk support the role of the hygiene hypothesis in IBD development.
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Colitis Ulcerosa , Enfermedades Inflamatorias del Intestino , Adolescente , Adulto , Brasil/epidemiología , Estudios de Casos y Controles , Colitis Ulcerosa/diagnóstico , Colitis Ulcerosa/epidemiología , Femenino , Humanos , Masculino , Factores de Riesgo , Adulto JovenRESUMEN
RESUMO: Este trabalho pretende demonstrar que, em Freud, a interpretação se configura como um ato criador de realidades. Em nosso percurso, partimos do exame das políticas da representação no mundo antigo para, em seguida, apontarmos as divergências entre o estatuto da interpretação em Freud e em Artemidoro. Ao final, nos interessa destacar que a interpretação analítica não descortina, mas funda, retroativamente, o passado.
Abstract: This paper intends to demonstrate that, on the psychoanalytic field, the interpretation is itself an act of creation. Starting from the analysis of the Ancient World's representation politiques, latter on we highlight some of the differences between the use of the interpretation in Freud and in Artemidorus. As we demonstrate in the end of this paper, the psychoanalytic interpretation doesn't reveal the past but establishes it retroactively.
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Psicoanálisis , Interpretación Psicoanalítica , Teoría FreudianaRESUMEN
O objetivo deste artigo é verificar se, e, em que medida o processo autogestionário em quatro Organizações de Trabalho Associado (OTAs) pode impulsionar transformações cotidianas das relações de trabalho, e se este processo está relacionado a outras perspectivas mais amplas de resistência política. Tal abordagem, influenciada pela pesquisa-ação e pela enquete operária de Karl Marx, interpreta o impacto da relação (autogestão x processo de consciência) e os seus condicionantes, para problematizar os avanços e desafios da autogestão como mediação para aprimorar o processo de consciência e autodeterminação dos/as trabalhadores/as, ou seja: as rupturas e as continuidades do Trabalho Associado com a antiga forma (heterogestionária) merecem e precisam ser apuradas. O cruzamento e a interpretação dos indicadores institucionais e comportamentais utilizados na pesquisa concluem a existência de 3 tipologias de consciência dominantes nas Organizações de Trabalho Associado em processo de autogestão.(AU)
The aim of this research is to verify if and to what extent the self-management process in four Associated Work Organizations drives daily transformations of labor relations and is related to other broader perspectives of political struggle. Such an approach, influenced by action research and worker poll, interprets the impact of the relationship (self-management x consciousness) and its constraints, to problematize the limits and possibilities of selfmanagement as mediation to improve the process of self-determination and self-determination workers, that is: the ruptures and continuities of Work Associated with the old form deserve and need to be unveiled. The intersection and interpretation of the institutional and behavioral indicators used in the research conclude the existence of 3 dominant typologies of consciousness in Associate Work Organizations in self-management process.
El patrón de sociabilidad forjado por el capital no puede ser superado por decreto, como en un pase de hechizos, o por la simple socialización de los medios de producción. El objetivo de esta investigación es verificar si, y en qué medida, el proceso autogestionario en cuatro Organizaciones de Trabajo Asociado impulsa transformaciones cotidianas de las relaciones de trabajo, y se relaciona con otras perspectivas más amplias de lucha política. Este enfoque, influenciado por la investigación-acción y la encuesta obrera, interpreta el impacto de la relación (autogestión x conciencia) y sus condicionantes, para problematizar los límites y las posibilidades de la autogestión como mediación para perfeccionar el proceso de conciencia y autodeterminación de los / as, los trabajadores / as, es decir: las rupturas y las continuidades del Trabajo Asociado con la antigua forma merecen y necesitan ser desveladas. La intersección e interpretación de los indicadores institucionales y de comportamiento utilizados en la investigación concluyen la existencia de 3 tipologías dominantes de conciencia en las Organizaciones de Trabajo Asociadas en el proceso de autogestión.(AU)
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Humanos , Trabajo , AutomanejoRESUMEN
Objetivo: Avaliar a influência do excesso de peso nos valores de pressão arterial (PA) de escolares 4 a 17 anos em uma cidade no interior de Sergipe. Metodologia: Trata-se de um estudo transversal, em que foram avaliados 119 estudantes de 5 escolas, por meio de avaliação antropométrica e obtenção dos valores da PA. Os estudantes foram classificados quanto seu estado nutricional e a presença de níveis pressóricos alte-rados de acordo com os percentis propostos pela Organização Mundial da Saúde e da Sociedade Brasileira de Cardiologia, respectivamente. Em seguida, os dados foram analisados estatisticamente com o programa GraphPad Prism V7.0., utilizando-se o teste de Mann Whitney para comparação e o coeficiente de Spearman para correlação entre duas variáveis, sendo adotado como nível de significância, 5%. Resultados:Dos 119 estudantes avaliados, 8,41% foram considerados com baixo peso, 38,32% eutróficos e 53,27% com excesso de peso. Os estudantes com excesso de peso apresentaram maiores medidas de circunferência abdominal. Observou-se uma correlação forte e positiva entre os valores de IMC-z e a razão CA/A, em que os estudantes com maiores valores de IMC-z possuíam também valores maiores da relação CA/A. Além disso, foi constatado maior número de estudantes com níveis considerados PA alterados, dentre aqueles que pos-suíam maiores medidas tanto de IMC-z e quanto da relação CA/A. Conclusão: Crianças e adolescentes com PA alterada apresentaram maior média de IMC e maior relação CA/A em comparação com as que possuíam PA normal, o que evidencia a necessidade de intervenção nessa população para prevenção e promoção da saúde.(AU)
Objective: To evaluate the influence of overweight on blood pressure (BP) values of schoolers aged 4 to 17 years in a city in the Sergipe countryside. Methodology: This is a cross-sectional study, in which 119 students from 5 schools were evaluated through anthropometric evaluation and BP values. The students were classified as their nutritional status and the presence of BP levels altered according to the percentiles proposed by the World Health Organization and the Brazilian Society of Cardi-ology, respectively. Data were then analyzed statistically in the GraphPad Prism V7.0 program, using the Mann Whitney test for comparison and the Spearman coefficient for correlation between two variables, being adopted as a significance level of 5%. Results: Of the 119 students evaluated, 8.41% were con-sidered underweight, 38.32% were eutrophic and 53.27% were overweight. Overweight students presented greater measures of Abdominal Circumference. A strong and positive correlation was also observed between the values of BMI-z and the CA/A ratio, where students with higher BMI-z values also had higher values of the CA/A ratio. In addition, a greater number of stu-dents with altered BP levels were observed among those who had greater measures of both BMI-z and CA/A ratio. Conclusion:Children and adolescents with altered BP had a higher mean BMI and higher CA/A ratio compared to those with normal BP, which reveals the need for intervention in this population for prevention and health promotion. (AU)
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Humanos , Masculino , Femenino , Sobrepeso , Obesidad Infantil , Antropometría , Presión ArterialRESUMEN
Introdução:O contato extracurricular com a pesquisa científica pode ajudar a melhorar as habilidades dos alunos e são muitos os potenciais influenciadores na adesão dos estudantes. Objetivo: Identificar níveis de conhecimento científico e atitudes científicas de estudantes de medicina bem como as principais barreiras para a prática científica. Casuística e Métodos: Estudo transversal realizado com acadêmicos de medicina do Campus Prof. Antônio Garcia Filho da Universidade Federal de Sergipe, Brasil. Aplicaram-se questionários validados a 90 estudantes que em seguida, foram agrupados em quatro classificações (não envolvidos em projetos; envolvidos em extensão; envolvidos em pesquisa e envolvidos em ambos (pesquisa e extensão). Resultados:Parcela significativa dos estudantes envolveu-se com projetos de pesquisa e extensão (43,33%) e as médias gerais de atitude e conhecimento científicos foram moderadas (56,85 ± 14,35; 47,28 ± 16,69). Os grupos de estudantes que participaram de pesquisa junto com extensão, apresentaram maiores pontuações de atitude científica (63,10 ± 13,69) e o conhecimento científico de todos os grupos foi similar. As barreiras, para a prática científica, mais citadas foram a falta de estrutura (73,33%), de tempo (70%), de orientação (67,78%), o foco nas atividades curriculares (54,44%) e falta de familiaridade com estatística (50%). Conclusão: Estudantes que apresentavam contato com pesquisa cientifica e extensão apresentaram atitudes mais positivas para pesquisa, demonstrando a importância do estímulo a essa prática. As barreiras, para as práticas científicas, mostraram-se similares à literatura mundial, mostrando que devem ser feitas medidas para reduzi-las e estimular a prática científica.
Introduction: Extracurricular contact with scientific research can help to improve students' skills and there are many potential influencers of students'adhesion. Objectives: Identify levels of scientific knowledge and attitudes towards scientific research among medical students, as well as the main barriers to scientific practice. C asuistic and methods:This is a cross-sectional study involving medical students from the Federal University of Sergipe, Brazil, Campus Prof. Antônio Garcia Filho. Validated questionnaires were applied to 90 students. Then, they were grouped in four classifications (not involved in projects; involved in non-degree projects; involved in research projects, and involved in both non-degree and research projects). Results: Significant parcel of students was involved on research and non-degree projects (43.33%). The overall averages of scientific knowledge and attitudes were moderate (56.85 ±14.35; 47.28 ±16.69). Groups of students involved in scientific research and community outreach, presented higher scores of scientific attitudes (63.10 ± 13.69). The scientific knowledge of all groups was similar. The most cited barriers for scientific practice were lacked of structure (73.33%), lack of time (70%), lack of orientation (67.78%), the focus on curricular activities (54.44%), and the lack of familiarity with statistics (50%). Conclusion: Students who had contact with scientific research and community outreach had more positive attitudes towards research, showing the importance of stimuli to this practice. The barriers for scientific practice were similar to world's data, showing that measures have to be taken to reduce them and stimulate the scientific research.
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Humanos , Educación en Salud/estadística & datos numéricos , Aprendizaje Basado en Problemas/estadística & datos numéricos , Educación MédicaRESUMEN
Justicia pectoralis Jacq. (Acanthaceae) leaves currently found in the Brazilian north-east are widely used to treat diabetes, menstrual pains, asthma, and other disorders. This work aimed to identify the phytochemical characterization and biological activities of J. pectoralis leaf extracts. The plant material was ground and the crude extracts were obtained with water or acetone: water (7:3 v/v), yielding aqueous (JPA), and organic (JPO) extracts. Phytochemical characterization was performed by thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC). Cytotoxicity was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) assay and trypan blue (TB) exclusion assay in peripheral blood mononuclear cells (PBMCs), BALB/c splenocytes, and neoplastic cells (TOLEDO, K562, DU-145, and PANC-1) at 1, 10, and 100 µg/mL. Antibacterial activity was evaluated using the microdilution test to obtain the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Cytokines, IFN-γ, and IL-17A from culture supernatants of BALB/c mice splenocytes were measured by sandwich ELISA. In the TLC analysis, both JPA and JPO extracts presented coumarin and flavonoids. In addition, HPLC was able to identify coumarin, apigenin, and ellagic acid in both extracts. JPO IC50 was 57.59 ± 1.03 µg/mL (MTT) and 69.44 ± 8.08 µg/mL (TB) in TOLEDO. MIC value of JPO against Acinetobacter baumannii and Klebsiella pneumoniae was 500 µg/mL. JPO (100 µg/mL) significantly inhibited IFN-γ levels (p=0.03). J. pectoralis is a potential candidate to be further investigated as an IFN-γ inhibitory agent and against Acinetobacter baumannii and Klebsiella pneumoniae.
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AIM: To identify environmental risk factors associated with the development of Crohn's disease (CD) in order to re-assess the hygiene hypothesis. METHODS: A hospital-based, case-control study was carried out with CD patients (n = 145) and controls (n = 163) representing a socioeconomically diverse statewide catchment area in Brazil. Controls were recruited from caregivers of patients seen in different outpatient clinics at the same hospital. A multi-item survey with 94 questions regarding family history of CD, perinatal and childhood circumstances, living conditions, tobacco use and familial socioeconomic status was carried out by interviewers. RESULTS: On the univariate analysis, predictive variables for CD included being male, under age of 40, a high education level, urban dweller, smaller family size, exposure to enteric pathogens and user of treated water (P < 0.005). On the multivariate analysis, variables significantly associated with CD were male gender (OR = 2.09), under age 40 (OR = 3.10), white (OR = 2.32), from a small family in childhood (OR = 2.34) and adulthood (OR = 3.02), absence of viral infections in childhood (OR = 2.23), exposure to enteric pathogens (OR = 2.41), having had an appendectomy (OR = 2.47) and prior or current smoker (OR = 2.83/1.12). CONCLUSION: Most variables supporting the "hygiene hypothesis" are associated with the development of CD but are not independent predictors of the diagnosis.
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Enfermedad de Crohn/epidemiología , Enfermedad de Crohn/inmunología , Exposición a Riesgos Ambientales/efectos adversos , Hipótesis de la Higiene , Fumar/efectos adversos , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , Apendicectomía/efectos adversos , Brasil/epidemiología , Estudios de Casos y Controles , Femenino , Humanos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Factores de Riesgo , Factores Sexuales , Clase Social , Encuestas y Cuestionarios , Adulto JovenRESUMEN
The present study evaluated the efficacy of a single oral dose of doramectin in the control of Psoroptes ovis and Leporacarus gibbus in naturally infested rabbits. Sixteen adult rabbits were selected and distributed in two experimental groups. The treated group received 200 µg/Kg of oral doramectin and the control group received the same volume of saline solution. The diagnosis of the mites was made with a stereoscopic microscope. Hairs from the dorsal part of the neck, lumbar right, lumbar left, ventral side of the tail and ventral abdomen were evaluated for L. gibbus, and ear wax evaluated for P. ovis. The evaluation of the efficiency and the clinical assessment of the lesions was made in days 0, +3, +7, +14, +21, +28, and +35 after treatment. An efficacy of 75% and 87,5% was observed for L. gibbus in days +3 and +7 after treatment, an efficacy of 100% was observed in days +14, + 21, +28 e +35. An efficacy of 100% for the control of P. ovis was observed following day +7. The clinical lesion score of the control group remained unaltered, except for one animal which conditions worsened during experimentation. In the treated group animals, regression of the lesions was observed following day +3, and on day +21 no signal of infestation by P. ovis was present. None of the animals from the treated group presented secondary collateral effects caused by the doramectin, which proved itself as an optimal alternative for mite control in naturally infested rabbits.(AU)
O objetivo do trabalho foi avaliar a eficácia da doramectina administrada por via oral no controle de Psoroptes ovis e Leporacarus gibbus em coelhos naturalmente infestados. Foram selecionados 16 coelhos adultos, distribuídos em dois grupos experimentais, compondo oito animais por grupo. O grupo tratado foi medicado com 200µg/kg de doramectina por via oral, enquanto que no grupo controle foi administrado o mesmo volume de solução salina. O diagnóstico dos ácaros foi realizado com auxílio de microscópio estereoscópico. Foram coletados pelos das regiões do pescoço dorsal, lombar direita, lombar esquerda, cauda ventral e abdômen ventral para avaliação de L. gibbus e para P. ovis foi coletado cerúmen das orelhas com auxílio de zaragatoas. A avaliação da eficácia e a avaliação clínica das lesões, mensuradas em escores (grau 0 a 4), foi realizada nos dias 0, +3, +7, +14, +21, +28 e +35, após o tratamento. Foi observada eficácia de 75% e 87,5% no controle de L. gibbus nos dias +3 e +7 após o tratamento, sendo observada eficácia de 100% nos dias +14, + 21, +28 e +35. Foi observada eficácia de 100% no controle de P. ovis a partir do dia +7, permanecendo até o final do período observacional. O escore das lesões clínicas no grupo controle permaneceu de forma inalterada, exceto em um animal que piorou ao longo dos dias experimentais, enquanto nos animais do grupo tratado regrediu a partir do dia +3 e já no dia +21 após o tratamento, os animais apresentavam-se sem sinais da infestação por P. ovis. Nenhum animal do grupo tratado apresentou quaisquer efeitos colaterais secundários causados pela doramectina, que se mostrou uma ótima alternativa para o controle dos ácaros em coelhos naturalmente parasitados.(AU)
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Animales , Conejos , Ácaros y Garrapatas/efectos de los fármacos , Antiparasitarios/uso terapéutico , Psoroptidae , Control de Ácaros y Garrapatas/métodos , Administración Oral , Infestaciones por Ácaros/terapia , Infestaciones por Ácaros/veterinariaRESUMEN
The present study evaluated the efficacy of a single oral dose of doramectin in the control of Psoroptes ovis and Leporacarus gibbus in naturally infested rabbits. Sixteen adult rabbits were selected and distributed in two experimental groups. The treated group received 200 g/Kg of oral doramectin and the control group received the same volume of saline solution. The diagnosis of the mites was made with a stereoscopic microscope. Hairs from the dorsal part of the neck, lumbar right, lumbar left, ventral side of the tail and ventral abdomen were evaluated for L. gibbus, and ear wax evaluated for P. ovis. The evaluation of the efficiency and the clinical assessment of the lesions was made in days 0, +3, +7, +14, +21, +28, and +35 after treatment. An efficacy of 75% and 87,5% was observed for L. gibbus in days +3 and +7 after treatment, an efficacy of 100% was observed in days +14, + 21, +28 e +35. An efficacy of 100% for the control of P. ovis was observed following day +7. The clinical lesion score of the control group remained unaltered, except for one animal which conditions worsened during experimentation. In the treated group animals, regression of the lesions was observed following day +3, and on day +21 no signal of infestation by P. ovis was present. None of the animals from the treated group presented secondary collateral effects caused by the doramectin, which proved itself as an optimal alternative for mite control in naturally infested rabbits.(AU)
O objetivo do trabalho foi avaliar a eficácia da doramectina administrada por via oral no controle de Psoroptes ovis e Leporacarus gibbus em coelhos naturalmente infestados. Foram selecionados 16 coelhos adultos, distribuídos em dois grupos experimentais, compondo oito animais por grupo. O grupo tratado foi medicado com 200g/kg de doramectina por via oral, enquanto que no grupo controle foi administrado o mesmo volume de solução salina. O diagnóstico dos ácaros foi realizado com auxílio de microscópio estereoscópico. Foram coletados pelos das regiões do pescoço dorsal, lombar direita, lombar esquerda, cauda ventral e abdômen ventral para avaliação de L. gibbus e para P. ovis foi coletado cerúmen das orelhas com auxílio de zaragatoas. A avaliação da eficácia e a avaliação clínica das lesões, mensuradas em escores (grau 0 a 4), foi realizada nos dias 0, +3, +7, +14, +21, +28 e +35, após o tratamento. Foi observada eficácia de 75% e 87,5% no controle de L. gibbus nos dias +3 e +7 após o tratamento, sendo observada eficácia de 100% nos dias +14, + 21, +28 e +35. Foi observada eficácia de 100% no controle de P. ovis a partir do dia +7, permanecendo até o final do período observacional. O escore das lesões clínicas no grupo controle permaneceu de forma inalterada, exceto em um animal que piorou ao longo dos dias experimentais, enquanto nos animais do grupo tratado regrediu a partir do dia +3 e já no dia +21 após o tratamento, os animais apresentavam-se sem sinais da infestação por P. ovis. Nenhum animal do grupo tratado apresentou quaisquer efeitos colaterais secundários causados pela doramectina, que se mostrou uma ótima alternativa para o controle dos ácaros em coelhos naturalmente parasitados.(AU)
Asunto(s)
Animales , Conejos , Psoroptidae , Ácaros y Garrapatas , Control de Ácaros y Garrapatas/métodos , Antiparasitarios/uso terapéutico , Infestaciones por Ácaros/terapia , Infestaciones por Ácaros/veterinaria , Administración OralRESUMEN
ABSTRACT: The present study evaluated the efficacy of a single oral dose of doramectin in the control of Psoroptes ovis and Leporacarus gibbus in naturally infested rabbits. Sixteen adult rabbits were selected and distributed in two experimental groups. The treated group received 200 g/Kg of oral doramectin and the control group received the same volume of saline solution. The diagnosis of the mites was made with a stereoscopic microscope. Hairs from the dorsal part of the neck, lumbar right, lumbar left, ventral side of the tail and ventral abdomen were evaluated for L. gibbus, and ear wax evaluated for P. ovis. The evaluation of the efficiency and the clinical assessment of the lesions was made in days 0, +3, +7, +14, +21, +28, and +35 after treatment. An efficacy of 75% and 87,5% was observed for L. gibbus in days +3 and +7 after treatment, an efficacy of 100% was observed in days +14, + 21, +28 e +35. An efficacy of 100% for the control of P. ovis was observed following day +7. The clinical lesion score of the control group remained unaltered, except for one animal which conditions worsened during experimentation. In the treated group animals, regression of the lesions was observed following day +3, and on day +21 no signal of infestation by P. ovis was present. None of the animals from the treated group presented secondary collateral effects caused by the doramectin, which proved itself as an optimal alternative for mite control in naturally infested rabbits.
RESUMO: O objetivo do trabalho foi avaliar a eficácia da doramectina administrada por via oral no controle de Psoroptes ovis e Leporacarus gibbus em coelhos naturalmente infestados. Foram selecionados 16 coelhos adultos, distribuídos em dois grupos experimentais, compondo oito animais por grupo. O grupo tratado foi medicado com 200g/kg de doramectina por via oral, enquanto que no grupo controle foi administrado o mesmo volume de solução salina. O diagnóstico dos ácaros foi realizado com auxílio de microscópio estereoscópico. Foram coletados pelos das regiões do pescoço dorsal, lombar direita, lombar esquerda, cauda ventral e abdômen ventral para avaliação de L. gibbus e para P. ovis foi coletado cerúmen das orelhas com auxílio de zaragatoas. A avaliação da eficácia e a avaliação clínica das lesões, mensuradas em escores (grau 0 a 4), foi realizada nos dias 0, +3, +7, +14, +21, +28 e +35, após o tratamento. Foi observada eficácia de 75% e 87,5% no controle de L. gibbus nos dias +3 e +7 após o tratamento, sendo observada eficácia de 100% nos dias +14, + 21, +28 e +35. Foi observada eficácia de 100% no controle de P. ovis a partir do dia +7, permanecendo até o final do período observacional. O escore das lesões clínicas no grupo controle permaneceu de forma inalterada, exceto em um animal que piorou ao longo dos dias experimentais, enquanto nos animais do grupo tratado regrediu a partir do dia +3 e já no dia +21 após o tratamento, os animais apresentavam-se sem sinais da infestação por P. ovis. Nenhum animal do grupo tratado apresentou quaisquer efeitos colaterais secundários causados pela doramectina, que se mostrou uma ótima alternativa para o controle dos ácaros em coelhos naturalmente parasitados.
RESUMEN
Este trabalho analisou a produção de sete edições do Encontro Nacional de Recreação e Lazer (ENAREL) e Seminário O Lazer em Debate (SLD) a partir do recorte geopolítico. Os dados foram coletados por meio da bibliometria e situam quais são as regiões, instituições e grupos de pesquisa com maior aporte de produção nos eventos. Os grupos de pesquisa/pós-graduações são predominantemente vindos da Educação Física e adotam abordagem interdisciplinar. O Sudeste é o maior pólo de produção, tendo UFMG, UNIMEP, USP e UNESP como as instituições com maior representatividade. Todavia, comparando a produção do PIB com a participação de cada unidade da federação, foi possível perceber movimentos regionais significativos no Norte e Nordeste, bem como situar o protagonismo dos grupos de pesquisa na produção e nucleação científica.
The last seven editions of two major events in Brazilian Leisure Studies (ENAREL e Seminário O Lazer em Debate) were analyzed. According to the bibliometric method, the approach to analyze data about research groups, regions and institutions was made by the geopolitics. The research groups/postgraduate programs are from Physical Education and interdisciplinary research was adopted with approach. Southeast of Brazil has the best production with four universities (UFMG, UNIMEP, USP and UNESP) leading on. However, some universities in underdeveloped states have been developing academic participation in national scene. Therefore, research groups and local initiatives can change the protagonists in Leisure Studies field.
Asunto(s)
Actividades RecreativasRESUMEN
O presente trabalho pretende demonstrar que, na primeira parte do ensino de Jacques Lacan, a assunção subjetiva do desejo enquanto falta-a-ser representa o ponto de chegada de uma psicanálise. Recorrendo aos textos inaugurais do seu ensino, veremos que é justamente a falta de um saber imanente, capaz de designar o objeto compatível com as suas necessidades, que impõe ao desejo sua negatividade, sintomaticamente expressa na forma do "que queres tu de mim?", com a qual o sujeito pretende reparar a inconsistência do Outro. Tal como propõe o psicanalista francês, uma experiência com a psicanálise levada ao seu limite deveria produzir a assunção pelo sujeito do seu desejo enquanto pura falta-a-ser, em razão da qual se liquidaria o seu endereçamento ao Outro como fundamento último.
This paper intends to demonstrate that, on the first part of Jacques Lacan's teaching, the appropriation of the desire as lack-of-being represents the aim of a psychoanalytical treatment. Referring to his very first texts and seminars, we will see that the lack of an immanent knowledge, capable of designating the object compatible with its necessities, which imposes to desire its negativity, symptomatically expressed on the form of the "che vuoi?", with which the subject intends to mend the Other's inconsistence. As proposes the French psychoanalyst, an experience with the psychoanalysis taken to its limits should produce the subject appropriation of the desire as pure lack-of-being, because of which it would liquidate its addressing to the Other as ultimate foundation.
El presente trabajo pretende demonstrar que, en la primera parte de la enseñanza de Jacques Lacan, la asunción subjetiva del deseo como falta-a-ser representa el punto de llegada de un psicoanálisis. Recurriendo a sus textos inaugurales de enseñanza, veremos que es justamente la falta de un saber inmanente capaz de designar el objeto compatible con sus necesidades lo que impone al deseo su negatividad. Negatividad sintomáticamente expresa en la forma del "¿qué quieres de mí?", con la cual el sujeto pretende reparar la inconsistencia del Otro. Como propone el psicoanalista francés, una experiencia con el psicoanálisis en su límite debería producir la asunción por el sujeto de su deseo como pura falta-a-ser, en razón de la cual se cerraría su enderezamiento al Otro como fundamento último.
Cet article vise à démontrer que, dans la première partie de l'enseignement de Jacques Lacan, l'appropriation subjetive du désir comme une manque-a-étre représente le point d'arrivée d'une psychanalyse. En utilisant ses premiers textes d'enseignement, nous voyons que c'est précisément l'absence d'un savoir immanent, capable de désigner l'objet compatible avec sa necessité, qui impose au désir sa négativité. Négativité symptomatique exprimé sous la forme de "Que voulez-vous de moi?", avec laquelle le sujet veut réparer l'inconsistance de l'autre. Telle que proposée par le psychanalyste français, une expérience avec la psychanalyse devrait produire l'assomption par le sujet de votre désir comme pur manque-à-être, en raison duquel résoudrait son adressage à l'autre comme fondement ultime.
Asunto(s)
Humanos , PsicoanálisisRESUMEN
O presente trabalho pretende demonstrar que, na primeira parte do ensino de Jacques Lacan, a assunção subjetiva do desejo enquanto falta-a-ser representa o ponto de chegada de uma psicanálise. Recorrendo aos textos inaugurais do seu ensino, veremos que é justamente a falta de um saber imanente, capaz de designar o objeto compatível com as suas necessidades, que impõe ao desejo sua negatividade, sintomaticamente expressa na forma do "que queres tu de mim?", com a qual o sujeito pretende reparar a inconsistência do Outro. Tal como propõe o psicanalista francês, uma experiência com a psicanálise levada ao seu limite deveria produzir a assunção pelo sujeito do seu desejo enquanto pura falta-a-ser, em razão da qual se liquidaria o seu endereçamento ao Outro como fundamento último.(AU)
This paper intends to demonstrate that, on the first part of Jacques Lacan's teaching, the appropriation of the desire as lack-of-being represents the aim of a psychoanalytical treatment. Referring to his very first texts and seminars, we will see that the lack of an immanent knowledge, capable of designating the object compatible with its necessities, which imposes to desire its negativity, symptomatically expressed on the form of the "che vuoi?", with which the subject intends to mend the Other's inconsistence. As proposes the French psychoanalyst, an experience with the psychoanalysis taken to its limits should produce the subject appropriation of the desire as pure lack-of-being, because of which it would liquidate its addressing to the Other as ultimate foundation.(AU)
El presente trabajo pretende demonstrar que, en la primera parte de la enseñanza de Jacques Lacan, la asunción subjetiva del deseo como falta-a-ser representa el punto de llegada de un psicoanálisis. Recurriendo a sus textos inaugurales de enseñanza, veremos que es justamente la falta de un saber inmanente capaz de designar el objeto compatible con sus necesidades lo que impone al deseo su negatividad. Negatividad sintomáticamente expresa en la forma del "¿qué quieres de mí?", con la cual el sujeto pretende reparar la inconsistencia del Otro. Como propone el psicoanalista francés, una experiencia con el psicoanálisis en su límite debería producir la asunción por el sujeto de su deseo como pura falta-a-ser, en razón de la cual se cerraría su enderezamiento al Otro como fundamento último.(AU)
Cet article vise à démontrer que, dans la première partie de l'enseignement de Jacques Lacan, l'appropriation subjetive du désir comme une manque-a-étre représente le point d'arrivée d'une psychanalyse. En utilisant ses premiers textes d'enseignement, nous voyons que c'est précisément l'absence d'un savoir immanent, capable de désigner l'objet compatible avec sa necessité, qui impose au désir sa négativité. Négativité symptomatique exprimé sous la forme de "Que voulez-vous de moi?", avec laquelle le sujet veut réparer l'inconsistance de l'autre. Telle que proposée par le psychanalyste français, une expérience avec la psychanalyse devrait produire l'assomption par le sujet de votre désir comme pur manque-à-être, en raison duquel résoudrait son adressage à l'autre comme fondement ultime.(AU)
Asunto(s)
PsicoanálisisRESUMEN
O objetivo do trabalho foi avaliar através de teste in vivo, a eficácia e o período residual de proteção do fipronil 10% "top spot" em cães infestados com diferentes cargas parasitárias de Ctenocephalides felis felis. Foram utilizados 24 cães da raça Beagle, compondo seis animais por grupo. Os cães foram divididos em quatro grupos. Os cães dos grupos controles I e II não receberam tratamento, enquanto que os cães dos grupos tratados I e II receberam tratamento com formulação de fipronil 10% "top spot". Os cães dos grupos controle I e tratado I foram infestados com 100 pulgas adultas não alimentadas, e os cães dos grupos controle II e tratado II foram infestados com 300 pulgas adultas não alimentadas. As infestações foram realizadas nos dias, -2, +5, +12, +19, +26, +33 e +40 e nos dias +2, +7, +14, +21, +28, +35 e +42 foi realizada retirada mecânica e contagem de pulgas para avaliação. As eficácias pulguicidas, para o grupo tratado I, nos dias +2, +7, +14, +21, +28, +35 e +42, foram respectivamente 99,36%; 99,73%; 99,48%; 99,74%; 99,75%; 95,06% e 67,62%. As eficácias pulguicidas, para o grupo tratado II, avaliadas nos mesmos dias, foram respectivamente 100%; 100%; 100%; 100%; 99,91%; 95,60% e 68,55%. O fipronil mostrou-se eficaz na eliminação das pulgas em cães até o dia +35. A análise estatística comparativa entre as médias de pulgas vivas, entre os grupos controle I e tratado I, demonstrou que ocorreu diferença significativa (p≤0,05) para os desafios em todos os dias experimentais, após o tratamento. Os grupos controle II e tratado II também apresentaram diferença significativa (p≤0,05) para os desafios em todos os dias experimentais, após o tratamento. A análise estatística entre os grupos tratados I e II demonstrou que não ocorreu diferença significativa (p≥0,05) para os desafios em todos os dias experimentais. O desafio foi encerrado no dia +42 já que a eficácia do fipronil nos grupos tratados I e II foram inferiores 70%. O produto em teste mostrou-se eficaz na eliminação das pulgas em cães até o dia + 35, não apresentando mais efeito residual de proteção quando os animais foram reinfestados. Não houve diferença significativa nos níveis de eficácia entre os grupos infestados com 100 e 300 exemplares adultos de C. felis felis ao longo do período experimental.(AU)
The objective of the study was to evaluate through in vivo test, the efficacy and residual period of protection of 10% fipronil "top spot" for dogs with different Ctenocephalides felis felis burdens of infestations. For this, 24 Beagles were used, divided into four groups of six dogs each. The dogs of the control groups I and II were not treated, while the dogs of the treated groups I e II were treated with the formulation of 10% fipronil "top spot". The dogs of the control group I and treated group I were infested with 100 unfed C. felis felis and dogs of group control II and treated II one were infested with 300 unfed C. felis felis each. Infestations were performed on days -2, +5, +12, +19, +26, +33 and +40, and on days +2, +7, +14, +21, +28, +35 and +42 fleas were mechanical removed and counted for evaluation. Efficacy for treated group I on days +2, +7, +14, +21, +28, +35 and +42 was respectively 99.36%, 99.73%, 99.48%, 99.00%, 74.00%, 99.75%, 95.06% and 67.62%. The efficacy for the treated group II, evaluated on the same days, was respectively 100%, 100%, 100%, 100%, 99.91, 95.60% and 68.55%. Fipronil was effective in eliminating fleas on dogs until day +35. The statistical comparisons of the mean living fleas between control I group and treated I one showed significant differences (p≤0.05) for the challenges on all experimental days after treatment. Control II group and treated II one also showed significant differences (p≤0.05) for the challenges on all experimental days after treatment. Statistical analysis between treated group I and II showed no significant difference (p≥0.05) between the challenges on all experimental days. The challenges were finished on day 42, when the effectiveness of fipronil in treated groups I and II were lower than 70%. The tested product was effective in eliminating fleas on dogs until day + 35 with no more residual effect of protection when the animals were reinfested. There was ...(AU)
Asunto(s)
Animales , Perros , Perros/parasitología , Ctenocephalides , Insecticidas/administración & dosificación , Compuestos Químicos/análisisRESUMEN
O objetivo do trabalho foi avaliar através de teste in vivo, a eficácia e o período residual de proteção do fipronil 10% "top spot" em cães infestados com diferentes cargas parasitárias de Ctenocephalides felis felis. Foram utilizados 24 cães da raça Beagle, compondo seis animais por grupo. Os cães foram divididos em quatro grupos. Os cães dos grupos controles I e II não receberam tratamento, enquanto que os cães dos grupos tratados I e II receberam tratamento com formulação de fipronil 10% "top spot". Os cães dos grupos controle I e tratado I foram infestados com 100 pulgas adultas não alimentadas, e os cães dos grupos controle II e tratado II foram infestados com 300 pulgas adultas não alimentadas. As infestações foram realizadas nos dias, -2, +5, +12, +19, +26, +33 e +40 e nos dias +2, +7, +14, +21, +28, +35 e +42 foi realizada retirada mecânica e contagem de pulgas para avaliação. As eficácias pulguicidas, para o grupo tratado I, nos dias +2, +7, +14, +21, +28, +35 e +42, foram respectivamente 99,36%; 99,73%; 99,48%; 99,74%; 99,75%; 95,06% e 67,62%...
The objective of the study was to evaluate through in vivo test, the efficacy and residual period of protection of 10% fipronil "top spot" for dogs with different Ctenocephalides felis felis burdens of infestations. For this, 24 Beagles were used, divided into four groups of six dogs each. The dogs of the control groups I and II were not treated, while the dogs of the treated groups I e II were treated with the formulation of 10% fipronil "top spot". The dogs of the control group I and treated group I were infested with 100 unfed C. felis felis and dogs of group control II and treated II one were infested with 300 unfed C. felis felis each. Infestations were performed on days -2, +5, +12, +19, +26, +33 and +40, and on days +2, +7, +14, +21, +28, +35 and +42 fleas were mechanical removed and counted for evaluation. Efficacy for treated group I on days +2, +7, +14, +21, +28, +35 and +42 was respectively 99.36%, 99.73%, 99.48%, 99.00%, 74.00%, 99.75%, 95.06% and 67.62%...
Asunto(s)
Animales , Perros , Perros/parasitología , Ctenocephalides , Insecticidas/administración & dosificación , Compuestos Químicos/análisisRESUMEN
AIM: To assess the vitamin A status of patients with Crohn's disease (CD) by evaluating serum retinol levels and the relative dose response (RDR) test (liver retinol stores). METHODS: Vitamin A nutritional status was measured by serum retinol obtained by high performance liquid chromatography and the RDR test for evaluation of the hepatic stores. Body composition was performed by densitometry by dual-energy X-ray absorptiometry. Vitamin A dietary intake was assessed from a semi-quantitative food frequency questionnaire. RESULTS: This study included 38 CD patients and 33 controls. Low serum retinol concentrations were detected in 29% of CD patients vs 15% in controls (P < 0.005). The RDR test was positive in 37% of CD patients vs 12% in controls, which indicated inadequate hepatic vitamin A stores (P < 0.005). Individuals with hypovitaminosis A had lower BMI and body fat compared with those without this deficiency. There was no association between vitamin A deficiency and its dietary intake, ileal location, presence of disease activity and prior bowel resections. CONCLUSION: Patients with CD have higher prevalence of vitamin A deficiency, as assessed by two independent methods.